R version 4.1.3 (2022-03-10) -- "One Push-Up"
Copyright (C) 2022 The R Foundation for Statistical Computing
Platform: i386-w64-mingw32/i386 (32-bit)

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> ####
> #### This code is messy, possibly incomplete and only for
> #### the use of developers.
> ####
> ####
> 
> test.c.code <-  FALSE
> test.PLM.modelmatrix <- FALSE
> test.rlm <- FALSE
> 
> if (test.c.code){
+   
+   library(affyPLM)
+   narrays <- 10
+   nprobes <- 11
+   nprobetypes <- 2
+   ncols <- 10
+   
+   MMs <- rnorm(narrays*nprobes*nprobetypes)
+   X <- matrix(0,narrays*nprobes*nprobetypes,ncols)
+   
+                                         #test making intercept column
+   matrix(.C("R_PLM_matrix_intercept",as.double(as.vector(X)), as.integer(narrays),as.integer(nprobes),as.integer(nprobetypes),0)[[1]],ncol=10)
+   
+                                         #test making an MM covariate column
+   matrix(.C("R_PLM_matrix_MM",as.double(as.vector(X)), as.integer(narrays),as.integer(nprobes),as.integer(nprobetypes),as.integer(1),as.double(MMs))[[1]],ncol=10)
+   
+                                         # sample effect aka chip effect, aka expression values
+   matrix(.C("R_PLM_matrix_sample_effect",as.double(as.vector(X)), as.integer(narrays),as.integer(nprobes),as.integer(nprobetypes),as.integer(0),as.integer(0))[[1]],ncol=10)
+   matrix(.C("R_PLM_matrix_sample_effect",as.double(as.vector(X)), as.integer(narrays),as.integer(nprobes),as.integer(nprobetypes),as.integer(0),as.integer(1))[[1]],ncol=10)
+   matrix(.C("R_PLM_matrix_sample_effect",as.double(as.vector(X)), as.integer(narrays),as.integer(nprobes),as.integer(nprobetypes),as.integer(0),as.integer(-1))[[1]],ncol=10)
+   
+   
+   
+                                         #probe-type parameter overall
+   matrix(.C("R_PLM_matrix_probe_type_effect",as.double(as.vector(X)), as.integer(narrays),as.integer(nprobes),as.integer(nprobetypes),as.integer(0),as.integer(0),as.integer(0),integer(narrays),as.integer(1))[[1]],ncol=10)
+   
+                                         #probe-type parameter within sample
+   matrix(.C("R_PLM_matrix_probe_type_effect",as.double(as.vector(X)), as.integer(narrays),as.integer(nprobes),as.integer(nprobetypes),as.integer(0),as.integer(1),as.integer(1),integer(narrays),as.integer(1))[[1]],ncol=10)
+   matrix(.C("R_PLM_matrix_probe_type_effect",as.double(as.vector(X)), as.integer(narrays),as.integer(nprobes),as.integer(nprobetypes),as.integer(0),as.integer(-1),as.integer(1),integer(narrays),as.integer(1))[[1]],ncol=10)
+   ncols <- 20
+   X <- matrix(0,narrays*nprobes*nprobetypes,ncols)
+   matrix(.C("R_PLM_matrix_probe_type_effect",as.double(as.vector(X)), as.integer(narrays),as.integer(nprobes),as.integer(nprobetypes),as.integer(0),as.integer(0),as.integer(1),integer(narrays),as.integer(0))[[1]],ncol=20)
+   
+   
+                                         #probe-type-parameter within a chip-level factor (eg treatment, or genotype variable)
+   trt.cov <- rep(0:1,5)
+   ncols <- 10
+   X <- matrix(0,narrays*nprobes*nprobetypes,ncols)
+   matrix(.C("R_PLM_matrix_probe_type_effect",as.double(as.vector(X)), as.integer(narrays),as.integer(nprobes),as.integer(nprobetypes),as.integer(0),as.integer(0),as.integer(2),as.integer(trt.cov),as.integer(1))[[1]],ncol=10)
+   matrix(.C("R_PLM_matrix_probe_type_effect",as.double(as.vector(X)), as.integer(narrays),as.integer(nprobes),as.integer(nprobetypes),as.integer(0),as.integer(1),as.integer(2),as.integer(trt.cov),as.integer(1))[[1]],ncol=10)
+   matrix(.C("R_PLM_matrix_probe_type_effect",as.double(as.vector(X)), as.integer(narrays),as.integer(nprobes),as.integer(nprobetypes),as.integer(0),as.integer(-1),as.integer(2),as.integer(trt.cov),as.integer(1))[[1]],ncol=10)
+   
+   trt.cov <- rep(0:4,2)
+   matrix(.C("R_PLM_matrix_probe_type_effect",as.double(as.vector(X)), as.integer(narrays),as.integer(nprobes),as.integer(nprobetypes),as.integer(0),as.integer(-1),as.integer(2),as.integer(trt.cov),as.integer(4))[[1]],ncol=10)
+   
+   
+   
+   
+                                         #probe effects - overall
+   ncols <- 11
+   X <- matrix(0,narrays*nprobes*nprobetypes,ncols)
+   
+   
+   matrix(.C("R_PLM_matrix_probe_effect",as.double(as.vector(X)), as.integer(narrays),as.integer(nprobes),as.integer(nprobetypes),as.integer(0),as.integer(0),as.integer(0),as.integer(trt.cov),as.integer(4))[[1]],ncol=11)
+   matrix(.C("R_PLM_matrix_probe_effect",as.double(as.vector(X)), as.integer(narrays),as.integer(nprobes),as.integer(nprobetypes),as.integer(0),as.integer(1),as.integer(0),as.integer(trt.cov),as.integer(4))[[1]],ncol=11)
+   matrix(.C("R_PLM_matrix_probe_effect",as.double(as.vector(X)), as.integer(narrays),as.integer(nprobes),as.integer(nprobetypes),as.integer(0),as.integer(-1),as.integer(0),as.integer(trt.cov),as.integer(4))[[1]],ncol=11)
+   
+   
+   
+                                         #probe effects within treatment or genotype factor
+   trt.cov <- rep(0:1,5)
+   ncols <- 22
+   X <- matrix(0,narrays*nprobes*nprobetypes,ncols)
+   matrix(.C("R_PLM_matrix_probe_effect",as.double(as.vector(X)), as.integer(narrays),as.integer(nprobes),as.integer(nprobetypes),as.integer(0),as.integer(0),as.integer(2),as.integer(trt.cov),as.integer(1))[[1]],ncol=22)
+   matrix(.C("R_PLM_matrix_probe_effect",as.double(as.vector(X)), as.integer(narrays),as.integer(nprobes),as.integer(nprobetypes),as.integer(0),as.integer(1),as.integer(2),as.integer(trt.cov),as.integer(1))[[1]],ncol=22)
+   matrix(.C("R_PLM_matrix_probe_effect",as.double(as.vector(X)), as.integer(narrays),as.integer(nprobes),as.integer(nprobetypes),as.integer(0),as.integer(-1),as.integer(2),as.integer(trt.cov),as.integer(1))[[1]],ncol=22)
+   
+   
+                                         #probe effects within probetype
+   matrix(.C("R_PLM_matrix_probe_effect",as.double(as.vector(X)), as.integer(narrays),as.integer(nprobes),as.integer(nprobetypes),as.integer(0),as.integer(0),as.integer(3),as.integer(trt.cov),as.integer(1))[[1]],ncol=22)
+   matrix(.C("R_PLM_matrix_probe_effect",as.double(as.vector(X)), as.integer(narrays),as.integer(nprobes),as.integer(nprobetypes),as.integer(0),as.integer(1),as.integer(3),as.integer(trt.cov),as.integer(1))[[1]],ncol=22)
+   matrix(.C("R_PLM_matrix_probe_effect",as.double(as.vector(X)), as.integer(narrays),as.integer(nprobes),as.integer(nprobetypes),as.integer(0),as.integer(-1),as.integer(3),as.integer(trt.cov),as.integer(1))[[1]],ncol=22)
+   
+   
+                                         #probe effects within probetype within treatment or genotype factor variable
+   trt.cov <- rep(0:1,5)
+   ncols <- 44
+   X <- matrix(0,narrays*nprobes*nprobetypes,ncols)
+   matrix(.C("R_PLM_matrix_probe_effect",as.double(as.vector(X)), as.integer(narrays),as.integer(nprobes),as.integer(nprobetypes),as.integer(0),as.integer(0),as.integer(4),as.integer(trt.cov),as.integer(1))[[1]],ncol=44)
+   matrix(.C("R_PLM_matrix_probe_effect",as.double(as.vector(X)), as.integer(narrays),as.integer(nprobes),as.integer(nprobetypes),as.integer(0),as.integer(1),as.integer(4),as.integer(trt.cov),as.integer(1))[[1]],ncol=44)
+   matrix(.C("R_PLM_matrix_probe_effect",as.double(as.vector(X)), as.integer(narrays),as.integer(nprobes),as.integer(nprobetypes),as.integer(0),as.integer(-1),as.integer(4),as.integer(trt.cov),as.integer(1))[[1]],ncol=44)
+   
+   nprobetypes <- 1
+   trt.cov <- rep(0:1,5)
+   ncols <- 44
+   X <- matrix(0,narrays*nprobes*nprobetypes,ncols)
+   matrix(.C("R_PLM_matrix_probe_effect",as.double(as.vector(X)), as.integer(narrays),as.integer(nprobes),as.integer(nprobetypes),as.integer(0),as.integer(0),as.integer(4),as.integer(trt.cov),as.integer(1))[[1]],ncol=44)
+   matrix(.C("R_PLM_matrix_probe_effect",as.double(as.vector(X)), as.integer(narrays),as.integer(nprobes),as.integer(nprobetypes),as.integer(0),as.integer(1),as.integer(4),as.integer(trt.cov),as.integer(1))[[1]],ncol=44)
+   matrix(.C("R_PLM_matrix_probe_effect",as.double(as.vector(X)), as.integer(narrays),as.integer(nprobes),as.integer(nprobetypes),as.integer(0),as.integer(-1),as.integer(4),as.integer(trt.cov),as.integer(1))[[1]],ncol=44)
+   
+   
+                                         # copy across chip level variables into model matrix
+   nprobetypes <- 1
+   trt.cov <- rep(0:1,5)
+   ncols <- 10
+   X <- matrix(0,narrays*nprobes*nprobetypes,ncols)
+   trt.variables <- rnorm(10)
+   
+   matrix(.C("R_PLM_matrix_chiplevel",as.double(as.vector(X)), as.integer(narrays),as.integer(nprobes),as.integer(nprobetypes),as.integer(0),as.double(trt.variables),as.integer(1))[[1]],ncol=10)
+ 
+ 
+ ###
+ ### Build a few design matrices and compare with R model.matrix
+ ###
+ 
+ 
+   for (nprobetypes in 1:2){
+     for (narrays in 2:15){
+       for (nprobes in 2:20){
+         for (constraint.type in c("contr.sum","contr.treatment")){
+           if (constraint.type == "contr.sum"){
+             ct.type <- -1
+           } else {
+             ct.type <- 1
+           }
+ 
+           
+           ncols <- nprobes -1 + narrays
+           X <- matrix(0,narrays*nprobes*nprobetypes,ncols)
+           
+           X <- matrix(.C("R_PLM_Matrix_constructtest",as.double(as.vector(X)), as.integer(narrays),as.integer(nprobes),as.integer(nprobetypes),as.integer(1),as.integer(1),as.integer(0),as.integer(1),as.integer(ct.type))[[1]],ncol=ncols)
+           
+           probe.effect <- factor(rep(1:nprobes,narrays*nprobetypes))
+           sample.effect <- factor(rep(rep(c(1:narrays),rep(nprobes,narrays)),nprobetypes))
+           if (nprobetypes == 2){
+             probe.type.effect <- factor(rep(1:2,c(narrays*nprobes,narrays*nprobes)))
+           } else {
+             probe.type.effect <- factor(rep(1,narrays*nprobes))
+           }
+           
+           if (any(X!=model.matrix(~ C(sample.effect,constraint.type) + C(probe.effect,constraint.type)))){
+             stop("Model matrix function problem ",narrays," ", nprobes, " ", nprobetypes)
+           }
+           
+           X <- matrix(0,narrays*nprobes*nprobetypes,ncols)
+           X <- matrix(.C("R_PLM_Matrix_constructtest",as.double(as.vector(X)), as.integer(narrays),as.integer(nprobes),as.integer(nprobetypes),as.integer(0),as.integer(1),as.integer(0),as.integer(1),as.integer(ct.type))[[1]],ncol=ncols)
+           
+           if (any(X!=model.matrix(~ -1 + C(sample.effect,constraint.type) + C(probe.effect,constraint.type)))){
+             stop("Model matrix function problem ",narrays," ", nprobes," ", nprobetypes)
+           }
+           
+           ncols <- nprobes
+           X <- matrix(0,narrays*nprobes*nprobetypes,ncols)
+           X <- matrix(.C("R_PLM_Matrix_constructtest",as.double(as.vector(X)), as.integer(narrays),as.integer(nprobes),as.integer(nprobetypes),as.integer(1),as.integer(0),as.integer(0),as.integer(1),as.integer(ct.type))[[1]],ncol=ncols)
+           
+           if (any(X!=model.matrix(~  C(probe.effect,constraint.type)))){
+             stop("Model matrix function problem ",narrays," ", nprobes," ", nprobetypes)
+           }
+           
+           
+           ncols <- nprobes
+           X <- matrix(0,narrays*nprobes*nprobetypes,ncols)
+           X <- matrix(.C("R_PLM_Matrix_constructtest",as.double(as.vector(X)), as.integer(narrays),as.integer(nprobes),as.integer(nprobetypes),as.integer(0),as.integer(0),as.integer(0),as.integer(1),as.integer(ct.type))[[1]],ncol=ncols)
+           
+           if (any(X!=model.matrix(~-1+  C(probe.effect,constraint.type)))){
+             stop("Model matrix function problem ",narrays," ", nprobes," ", nprobetypes)
+           }
+           
+         }
+       }
+     }
+   }
+   
+ ###
+ ### Build a few more design matrices and compare with R model.matrix
+ ###
+ 
+   
+   for (narrays in 2:15){
+     for (nprobes in 2:20){
+       for (constraint.type in c("contr.sum","contr.treatment")){
+         probe.effect <- factor(rep(1:nprobes,narrays*nprobetypes))
+         sample.effect <- factor(rep(rep(c(1:narrays),rep(nprobes,narrays)),nprobetypes))
+         if (constraint.type == "contr.sum"){
+           ct.type <- -1
+         } else {
+           ct.type <- 1
+         }
+ 
+        
+         if (nprobetypes == 2){
+           probe.type.effect <- factor(rep(1:2,c(narrays*nprobes,narrays*nprobes)))
+         } else {
+           probe.type.effect <- factor(rep(1,narrays*nprobes))
+         }
+         ncols <- nprobetypes + nprobes -1
+         X <- matrix(0,narrays*nprobes*nprobetypes,ncols)
+         X <- matrix(.C("R_PLM_Matrix_constructtest",as.double(as.vector(X)), as.integer(narrays),as.integer(nprobes),as.integer(nprobetypes),as.integer(0),as.integer(0),as.integer(1),as.integer(1),as.integer(ct.type))[[1]],ncol=ncols)
+         
+         if (any(X!=model.matrix(~-1+ C(probe.type.effect,constraint.type) +  C(probe.effect,constraint.type)))){
+           stop("Model matrix function problem ",narrays," ", nprobes," ", nprobetypes)
+         }
+         
+         ncols <- nprobetypes + nprobes -1
+         X <- matrix(0,narrays*nprobes*nprobetypes,ncols)
+         X <- matrix(.C("R_PLM_Matrix_constructtest",as.double(as.vector(X)), as.integer(narrays),as.integer(nprobes),as.integer(nprobetypes),as.integer(1),as.integer(0),as.integer(1),as.integer(1),as.integer(ct.type))[[1]],ncol=ncols)
+         
+         if (any(X!=model.matrix(~ C(probe.type.effect,constraint.type) +  C(probe.effect,constraint.type)))){
+           stop("Model matrix function problem ",narrays," ", nprobes," ", nprobetypes)
+         }
+         
+         ncols <- narrays + nprobetypes + nprobes -2
+         X <- matrix(0,narrays*nprobes*nprobetypes,ncols)
+         X <- matrix(.C("R_PLM_Matrix_constructtest",as.double(as.vector(X)), as.integer(narrays),as.integer(nprobes),as.integer(nprobetypes),as.integer(0),as.integer(1),as.integer(1),as.integer(1),as.integer(ct.type))[[1]],ncol=ncols)
+         
+         if (any(X!=model.matrix(~ -1 + C(sample.effect,constraint.type) + C(probe.type.effect,constraint.type) +  C(probe.effect,constraint.type)))){
+           stop("Model matrix function problem ",narrays," ", nprobes," ", nprobetypes)
+         }
+         
+         ncols <- narrays + nprobetypes + nprobes -2
+         X <- matrix(0,narrays*nprobes*nprobetypes,ncols)
+         X <- matrix(.C("R_PLM_Matrix_constructtest",as.double(as.vector(X)), as.integer(narrays),as.integer(nprobes),as.integer(nprobetypes),as.integer(1),as.integer(1),as.integer(1),as.integer(1),as.integer(ct.type))[[1]],ncol=ncols)
+         
+         if (any(X!=model.matrix(~ + C(sample.effect,constraint.type) + C(probe.type.effect,constraint.type) +  C(probe.effect,constraint.type)))){
+           stop("Model matrix function problem ",narrays," ", nprobes," ", nprobetypes)
+         }
+         
+         ncols <- narrays + nprobetypes -1
+         X <- matrix(0,narrays*nprobes*nprobetypes,ncols)
+         X <- matrix(.C("R_PLM_Matrix_constructtest",as.double(as.vector(X)), as.integer(narrays),as.integer(nprobes),as.integer(nprobetypes),as.integer(1),as.integer(1),as.integer(1),as.integer(0),as.integer(ct.type))[[1]],ncol=ncols)
+         
+         if (any(X!=model.matrix(~ C(sample.effect,constraint.type) + C(probe.type.effect,constraint.type)))){
+           stop("Model matrix function problem ",narrays," ", nprobes," ", nprobetypes)
+         }    
+         
+         ncols <- narrays + nprobetypes -1
+         X <- matrix(0,narrays*nprobes*nprobetypes,ncols)
+         X <- matrix(.C("R_PLM_Matrix_constructtest",as.double(as.vector(X)), as.integer(narrays),as.integer(nprobes),as.integer(nprobetypes),as.integer(0),as.integer(1),as.integer(1),as.integer(0),as.integer(ct.type))[[1]],ncol=ncols)
+         
+         if (any(X!=model.matrix(~ -1 + C(sample.effect,constraint.type) + C(probe.type.effect,constraint.type)))){
+           stop("Model matrix function problem ",narrays," ", nprobes," ", nprobetypes)
+         }    
+         
+         ncols <- nprobetypes
+         X <- matrix(0,narrays*nprobes*nprobetypes,ncols)
+         X <- matrix(.C("R_PLM_Matrix_constructtest",as.double(as.vector(X)), as.integer(narrays),as.integer(nprobes),as.integer(nprobetypes),as.integer(1),as.integer(0),as.integer(1),as.integer(0),as.integer(ct.type))[[1]],ncol=ncols)
+         
+         if (any(X!=model.matrix(~ C(probe.type.effect,constraint.type)))){
+           stop("Model matrix function problem ",narrays," ", nprobes," ", nprobetypes)
+         }    
+       
+         ncols <- nprobetypes
+         X <- matrix(0,narrays*nprobes*nprobetypes,ncols)
+         X <- matrix(.C("R_PLM_Matrix_constructtest",as.double(as.vector(X)), as.integer(narrays),as.integer(nprobes),as.integer(nprobetypes),as.integer(0),as.integer(0),as.integer(1),as.integer(0),as.integer(ct.type))[[1]],ncol=ncols)
+         
+         if (any(X!=model.matrix(~-1 +  C(probe.type.effect,constraint.type)))){
+           stop("Model matrix function problem ",narrays," ", nprobes," ", nprobetypes)
+         }    
+         
+       }
+       
+       
+     }
+   }
+ 
+ 
+   narrays <- 2
+   nprobes <- 7
+   nprobetypes <- 2
+   
+   probe.effect <- factor(rep(1:nprobes,narrays*nprobetypes))
+   sample.effect <- factor(rep(rep(c(1:narrays),rep(nprobes,narrays)),nprobetypes))
+   if (constraint.type == "contr.sum"){
+     ct.type <- -1
+   } else {
+     ct.type <- 1
+   }
+   
+   
+   if (nprobetypes == 2){
+     probe.type.effect <- factor(rep(1:2,c(narrays*nprobes,narrays*nprobes)))
+   } else {
+     probe.type.effect <- factor(rep(1,narrays*nprobes))
+   }
+   
+ 
+   model.matrix(~-1 +probe.effect/probe.type.effect)
+ 
+ 
+   library(affyPLM)
+   output <- verify.output.param(list(weights = FALSE, residuals = FALSE, varcov = "none", resid.SE = TRUE))
+   modelparam <- list(trans.fn="log2", se.type = 4, psi.type = 0, psi.k =1.345,max.its = 20, init.method = "ls",weights.chip=NULL,weights.probe=NULL)
+ 
+   library(affydata)
+   data(Dilution)
+ 
+   # fit a PM ~ samples model
+   R.model <- list(mmorpm.covariate=0,response.variable=1,which.parameter.types=as.integer(c(0,0,1,0,0)),strata=as.integer(c(0,0,0,0,0)),constraints=as.integer(c(0,0,0,0,0)),probe.type.trt.factor=NULL,max.probe.type.trt.factor=0,probe.trt.factor=NULL,max.probe.trt.factor=0,chipcovariates =matrix(0,0,0), probe.type.levels=list(),probe.trt.levels=list())
+   Fitresults <- .Call("rlm_PLMset",pm(Dilution),mm(Dilution),probeNames(Dilution),length(geneNames(Dilution)),R.model,output,modelparam)
+ 
+ 
+   sample.effect <- rep(1:4,c(16,16,16,16))
+   probe.effect <- rep(1:16,4)
+ 
+   library(MASS)
+   fit <- rlm(as.vector(log2(pm(Dilution)[1:16,])) ~ -1 + factor(sample.effect))
+   
+   if (any(Fitresults[[1]][1,] != coef(fit))){
+     stop("Problem in model fitting procedure")
+   }
+ 
+   sample.effect <- rep(1:4,c(20,20,20,20))
+   probe.effect <- rep(1:20,4)
+   fit <- rlm(as.vector(log2(pm(Dilution)[201781:201800,])) ~ -1 + factor(sample.effect))
+    if (any(Fitresults[[1]][12625,] != coef(fit))){
+     stop("Problem in model fitting procedure")
+   }
+ 
+ 
+   # fit a samples + probes model
+   R.model <- list(mmorpm.covariate=0,response.variable=1,which.parameter.types=as.integer(c(0,0,1,0,1)),strata=as.integer(c(0,0,0,0,0)),constraints=as.integer(c(0,0,0,0,-1)),probe.type.trt.factor=NULL,max.probe.type.trt.factor=0,probe.trt.factor=NULL,max.probe.trt.factor=0,chipcovariates =matrix(0,0,0), probe.type.levels=list(),probe.trt.levels=list())
+ 
+   Fitresults <- .Call("rlm_PLMset",pm(Dilution),mm(Dilution),probeNames(Dilution),length(geneNames(Dilution)),R.model,output,modelparam)
+   sample.effect <- rep(1:4,c(16,16,16,16))
+   probe.effect <- rep(1:16,4)
+ 
+   fit <- rlm(as.vector(log2(pm(Dilution)[1:16,])) ~ -1 + factor(sample.effect)+C(factor(probe.effect),"contr.sum"))
+   
+   if (any(abs(Fitresults[[1]][1,] -coef(fit)[1:4]) > 1e-13)){
+     stop("Problem in model fitting procedure")
+   }
+ 
+    if (any(abs(as.vector(Fitresults[[2]][[1]]) - coef(fit)[5:19]) > 1e-13)){
+     stop("Problem in model fitting procedure")
+   }
+ 
+ 
+ 
+   
+   sample.effect <- rep(1:4,c(20,20,20,20))
+   probe.effect <- rep(1:20,4)
+   fit <- rlm(as.vector(log2(pm(Dilution)[201781:201800,])) ~ -1 + factor(sample.effect)+C(factor(probe.effect),"contr.sum"))
+   
+   if (any(abs(Fitresults[[1]][12625,]  -coef(fit)[1:4])> 1e-13)){
+     stop("Problem in model fitting procedure")
+   }
+ 
+   if (any(abs(as.vector(Fitresults[[2]][[12625]])- coef(fit)[5:23])>1e-13)){
+     stop("Problem in model fitting procedure")
+   }
+ 
+   # fit an MM ~ samples model
+   R.model <- list(mmorpm.covariate=0,response.variable=-1,which.parameter.types=as.integer(c(0,0,1,0,0)),strata=as.integer(c(0,0,0,0,0)),constraints=as.integer(c(0,0,0,0,0)),probe.type.trt.factor=NULL,max.probe.type.trt.factor=0,probe.trt.factor=NULL,max.probe.trt.factor=0,chipcovariates =matrix(0,0,0), probe.type.levels=list(),probe.trt.levels=list())
+   Fitresults <- .Call("rlm_PLMset",pm(Dilution),mm(Dilution),probeNames(Dilution),length(geneNames(Dilution)),R.model,output,modelparam)
+ 
+ 
+   sample.effect <- rep(1:4,c(16,16,16,16))
+   probe.effect <- rep(1:16,4)
+ 
+   library(MASS)
+   fit <- rlm(as.vector(log2(mm(Dilution)[1:16,])) ~ -1 + factor(sample.effect))
+   
+   if (any(abs(Fitresults[[1]][1,] - coef(fit)) > 1e-13)){
+     stop("Problem in model fitting procedure")
+   }
+ 
+   sample.effect <- rep(1:4,c(20,20,20,20))
+   probe.effect <- rep(1:20,4)
+   fit <- rlm(as.vector(log2(mm(Dilution)[201781:201800,])) ~ -1 + factor(sample.effect))
+    if (any(abs(Fitresults[[1]][12625,] - coef(fit))>1e-13)){
+     stop("Problem in model fitting procedure")
+   }
+ 
+   # fit a MM ~ samples + probes model
+   R.model <- list(mmorpm.covariate=0,response.variable=-1,which.parameter.types=as.integer(c(0,0,1,0,1)),strata=as.integer(c(0,0,0,0,0)),constraints=as.integer(c(0,0,0,0,-1)),probe.type.trt.factor=NULL,max.probe.type.trt.factor=0,probe.trt.factor=NULL,max.probe.trt.factor=0,chipcovariates =matrix(0,0,0), probe.type.levels=list(),probe.trt.levels=list())
+ 
+   Fitresults <- .Call("rlm_PLMset",pm(Dilution),mm(Dilution),probeNames(Dilution),length(geneNames(Dilution)),R.model,output,modelparam)
+   sample.effect <- rep(1:4,c(16,16,16,16))
+   probe.effect <- rep(1:16,4)
+ 
+   fit <- rlm(as.vector(log2(mm(Dilution)[1:16,])) ~ -1 + factor(sample.effect)+C(factor(probe.effect),"contr.sum"))
+   
+   if (any(abs(Fitresults[[1]][1,]-coef(fit)[1:4]) > 1e-13)){
+     stop("Problem in model fitting procedure")
+   }
+ 
+    if (any(abs(as.vector(Fitresults[[2]][[1]])- coef(fit)[5:19])>1e-13)){
+     stop("Problem in model fitting procedure")
+   }
+ 
+ 
+ 
+   
+   sample.effect <- rep(1:4,c(20,20,20,20))
+   probe.effect <- rep(1:20,4)
+   fit <- rlm(as.vector(log2(mm(Dilution)[201781:201800,])) ~ -1 + factor(sample.effect)+C(factor(probe.effect),"contr.sum"))
+   
+   if (any(abs(Fitresults[[1]][12625,]- coef(fit)[1:4])>1e-13)){
+     stop("Problem in model fitting procedure")
+   }
+ 
+   if (any(abs(as.vector(Fitresults[[2]][[12625]])-coef(fit)[5:23])>1e14)){
+     stop("Problem in model fitting procedure")
+   }
+ 
+ 
+   # a treatment model
+   treatment.effect <- c(1,1,2,2)
+ 
+   covariates <- model.matrix(~ -1 + as.factor(treatment.effect))
+ 
+     R.model <- list(mmorpm.covariate=0,response.variable=-1,which.parameter.types=as.integer(c(0,1,0,0,0)),strata=as.integer(c(0,0,0,0,0)),constraints=as.integer(c(0,0,0,0,0)),probe.type.trt.factor=NULL,max.probe.type.trt.factor=0,probe.trt.factor=NULL,max.probe.trt.factor=0,chipcovariates =covariates, probe.type.levels=list(),probe.trt.levels=list())
+   
+ Fitresults <- .Call("rlm_PLMset",pm(Dilution),mm(Dilution),probeNames(Dilution),length(geneNames(Dilution)),R.model,output,modelparam)
+   
+   treatment.effect <- rep(c(1,1,2,2),c(16,16,16,16))
+   fit <- rlm(as.vector(log2(mm(Dilution)[1:16,])) ~ -1 + factor(treatment.effect))
+   
+   if (any(abs(Fitresults[[1]][1,]-coef(fit)[1:2]) > 1e-13)){
+     stop("Problem in model fitting procedure")
+   }
+ 
+    output <-  verify.output.param(list(weights = FALSE, residuals = FALSE, varcov = "none", resid.SE = TRUE))
+   modelparam <- list(trans.fn="log2", se.type = 4, psi.type = 0, psi.k =1.345,max.its = 20, init.method = "ls",weights.chip=NULL,weights.probe=NULL)
+ 
+ 
+   # a treatment + probes model with contr.treatment constraint
+   R.model <- list(mmorpm.covariate=0,response.variable=-1,which.parameter.types=as.integer(c(0,1,0,0,1)),strata=as.integer(c(0,0,0,0,0)),constraints=as.integer(c(0,0,0,0,1)),probe.type.trt.factor=NULL,max.probe.type.trt.factor=0,probe.trt.factor=NULL,max.probe.trt.factor=0,chipcovariates =covariates, probe.type.levels=list(),probe.trt.levels=list())
+   
+   Fitresults <- .Call("rlm_PLMset",pm(Dilution),mm(Dilution),probeNames(Dilution),length(geneNames(Dilution)),R.model,output,modelparam)
+   
+   
+   treatment.effect <- rep(c(1,1,2,2),c(20,20,20,20))
+   probe.effect <- rep(1:20,4)
+   fit <- rlm(as.vector(log2(mm(Dilution)[201761:201780,])) ~ -1 + factor(treatment.effect)+C(factor(probe.effect),"contr.treatment"))
+   
+   if (any(abs(Fitresults[[1]][12624,]-coef(fit)[1:2]) > 1e-13)){
+     stop("Problem in model fitting procedure")
+   }
+ 
+   if (any(abs(as.vector(Fitresults[[2]][[12624]])-coef(fit)[3:21])>1e14)){
+     stop("Problem in model fitting procedure")
+   }
+ 
+ 
+   
+   
+   # MM + samples + probes
+   R.model <- list(mmorpm.covariate=1,response.variable=1,which.parameter.types=as.integer(c(0,0,0,0,0)),strata=as.integer(c(0,0,0,0,0)),constraints=as.integer(c(0,0,0,0,0)),probe.type.trt.factor=NULL,max.probe.type.trt.factor=0,probe.trt.factor=NULL,max.probe.trt.factor=0,chipcovariates =matrix(0,0,0), probe.type.levels=list(),probe.trt.levels=list())
+ 
+ 
+   Fitresults <- .Call("rlm_PLMset",pm(Dilution),mm(Dilution),probeNames(Dilution),length(geneNames(Dilution)),R.model,output,modelparam)
+   
+   
+  sample.effect <- rep(1:4,c(16,16,16,16))
+   probe.effect <- rep(1:16,4)
+ 
+   fit <- rlm(as.vector(log2(pm(Dilution)[1:16,])) ~ -1 + as.vector(log2(mm(Dilution)[1:16,])))
+   
+ 
+   if (any(abs(as.vector(Fitresults[[6]][[1]]) - coef(fit)) > 1e-13)){
+     stop("Problem in model fitting procedure")
+   }
+ 
+   R.model <- list(mmorpm.covariate=1,response.variable=1,which.parameter.types=as.integer(c(0,0,1,0,0)),strata=as.integer(c(0,0,0,0,0)),constraints=as.integer(c(0,0,0,0,0)),probe.type.trt.factor=NULL,max.probe.type.trt.factor=0,probe.trt.factor=NULL,max.probe.trt.factor=0,chipcovariates =matrix(0,0,0),probe.type.levels=list(),probe.trt.levels=list())
+ 
+ 
+   Fitresults <- .Call("rlm_PLMset",pm(Dilution),mm(Dilution),probeNames(Dilution),length(geneNames(Dilution)),R.model,output,modelparam)
+   
+   fit <- rlm(as.vector(log2(pm(Dilution)[1:16,])) ~ -1 + as.vector(log2(mm(Dilution)[1:16,]))+ as.factor(sample.effect))
+   if (any(abs(as.vector(Fitresults[[6]][[1]]) - coef(fit)[1]) > 1e-13)){
+     stop("Problem in model fitting procedure")
+   }
+ 
+  if (any(abs(as.vector(Fitresults[[1]][1,]) - coef(fit)[2:5]) > 1e-13)){
+     stop("Problem in model fitting procedure")
+   }
+ 
+   R.model <- list(mmorpm.covariate=1,response.variable=1,which.parameter.types=as.integer(c(0,0,1,0,1)),strata=as.integer(c(0,0,0,0,0)),constraints=as.integer(c(0,0,0,0,-1)),probe.type.trt.factor=NULL,max.probe.type.trt.factor=0,probe.trt.factor=NULL,max.probe.trt.factor=0,chipcovariates =matrix(0,0,0),probe.type.levels=list(),probe.trt.levels=list())
+ 
+ 
+   Fitresults <- .Call("rlm_PLMset",pm(Dilution),mm(Dilution),probeNames(Dilution),length(geneNames(Dilution)),R.model,output,modelparam)
+   
+   fit <- rlm(as.vector(log2(pm(Dilution)[1:16,])) ~ -1 + as.vector(log2(mm(Dilution)[1:16,]))+ as.factor(sample.effect) + C(as.factor(probe.effect),"contr.sum"))
+   if (any(abs(as.vector(Fitresults[[6]][[1]]) - coef(fit)[1]) > 1e-13)){
+     stop("Problem in model fitting procedure")
+   }
+ 
+   if (any(abs(as.vector(Fitresults[[1]][1,]) - coef(fit)[2:5]) > 1e-13)){
+     stop("Problem in model fitting procedure")
+   }
+ 
+ 
+   ## PM and MM are response
+ 
+   
+   sample.effect <- rep(1:4,c(32,32,32,32))
+   probe.effect <- rep(1:16,8)
+   
+ 
+   
+   # PMMM ~ -1 + samples
+   R.model <- list(mmorpm.covariate=0,response.variable=0,which.parameter.types=as.integer(c(0,0,1,0,0)),strata=as.integer(c(0,0,0,0,0)),constraints=as.integer(c(0,0,0,0,0)),probe.type.trt.factor=NULL,max.probe.type.trt.factor=0,probe.trt.factor=NULL,max.probe.trt.factor=0,chipcovariates =matrix(0,0,0),probe.type.levels=list(),probe.trt.levels=list())
+   Fitresults <- .Call("rlm_PLMset",pm(Dilution),mm(Dilution),probeNames(Dilution),length(geneNames(Dilution)),R.model,output,modelparam)
+   
+   
+   fit <- rlm(as.vector(rbind(log2(pm(Dilution)[1:16,]),log2(mm(Dilution)[1:16,]))) ~ -1 + as.factor(sample.effect))
+   if (any(abs(as.vector(Fitresults[[1]][1,]) - coef(fit)) > 1e-13)){
+     stop("Problem in model fitting procedure")
+   }
+ 
+   # PMMM ~ -1 + samples +PROBES
+   R.model <- list(mmorpm.covariate=0,response.variable=0,which.parameter.types=as.integer(c(0,0,1,0,1)),strata=as.integer(c(0,0,0,0,0)),constraints=as.integer(c(0,0,0,0,-1)),probe.type.trt.factor=NULL,max.probe.type.trt.factor=0,probe.trt.factor=NULL,max.probe.trt.factor=0,chipcovariates =matrix(0,0,0),probe.type.levels=list(),probe.trt.levels=list())
+   Fitresults <- .Call("rlm_PLMset",pm(Dilution),mm(Dilution),probeNames(Dilution),length(geneNames(Dilution)),R.model,output,modelparam)
+   
+   fit <- rlm(as.vector(rbind(log2(pm(Dilution)[1:16,]),log2(mm(Dilution)[1:16,]))) ~ -1 + as.factor(sample.effect)+C(as.factor(probe.effect),"contr.sum") )
+   if (any(abs(as.vector(Fitresults[[1]][1,]) - coef(fit)[1:4]) > 1e-13)){
+     stop("Problem in model fitting procedure")
+   }
+ 
+   # a probe.type effect
+   probe.type.effect <- rep(rep(1:2,c(16,16)),4)
+ 
+   # PMMM ~ -1 + samples + probe.type + PROBES
+   R.model <- list(mmorpm.covariate=0,response.variable=0,which.parameter.types=as.integer(c(0,0,1,1,1)),strata=as.integer(c(0,0,0,0,0)),constraints=as.integer(c(0,0,0,-1,-1)),probe.type.trt.factor=NULL,max.probe.type.trt.factor=0,probe.trt.factor=NULL,max.probe.trt.factor=0,chipcovariates =matrix(0,0,0),probe.type.levels=list(),probe.trt.levels=list())
+   Fitresults <- .Call("rlm_PLMset",pm(Dilution),mm(Dilution),probeNames(Dilution),length(geneNames(Dilution)),R.model,output,modelparam)
+   
+   fit <- rlm(as.vector(rbind(log2(pm(Dilution)[1:16,]),log2(mm(Dilution)[1:16,]))) ~ -1 + as.factor(sample.effect)+ C(as.factor(probe.type.effect),"contr.sum")+ C(as.factor(probe.effect),"contr.sum") )
+   
+    if (any(abs(as.vector(Fitresults[[1]][1,]) - coef(fit)[1:4]) > 1e-13)){
+     stop("Problem in model fitting procedure")
+   }
+ 
+    if (any(abs(as.vector(Fitresults[[6]][1,]) - coef(fit)[5]) > 1e-13)){
+     stop("Problem in model fitting procedure")
+   }
+ 
+ 
+ 
+   #### store weights PM ~ -1 + samples
+ 
+   output <-  verify.output.param(list(weights = TRUE, residuals = TRUE, varcov = "none", resid.SE = TRUE))
+   modelparam <- list(trans.fn="log2", se.type = 4, psi.type = 0, psi.k =1.345,max.its = 20, init.method = "ls",weights.chip=NULL,weights.probe=NULL)
+ 
+   
+   R.model <- list(mmorpm.covariate=0,response.variable=1,which.parameter.types=as.integer(c(0,0,1,0,0)),strata=as.integer(c(0,0,0,0,0)),constraints=as.integer(c(0,0,0,0,0)),probe.type.trt.factor=NULL,max.probe.type.trt.factor=0,probe.trt.factor=NULL,max.probe.trt.factor=0,chipcovariates =matrix(0,0,0),probe.type.levels=list(),probe.trt.levels=list())
+   Fitresults <- .Call("rlm_PLMset",pm(Dilution),mm(Dilution),probeNames(Dilution),length(geneNames(Dilution)),R.model,output,modelparam)
+  
+ 
+ #### store weights PMMM ~ -1 + samples
+ 
+   output <-  verify.output.param(list(weights = TRUE, residuals = TRUE, varcov = "none", resid.SE = TRUE))
+   modelparam <- list(trans.fn="log2", se.type = 4, psi.type = 0, psi.k =1.345,max.its = 20, init.method = "ls",weights.chip=NULL,weights.probe=NULL)
+ 
+   
+   R.model <- list(mmorpm.covariate=0,response.variable=0,which.parameter.types=as.integer(c(0,0,1,0,0)),strata=as.integer(c(0,0,0,0,0)),constraints=as.integer(c(0,0,0,0,0)),probe.type.trt.factor=NULL,max.probe.type.trt.factor=0,probe.trt.factor=NULL,max.probe.trt.factor=0,chipcovariates =matrix(0,0,0),probe.type.levels=list(),probe.trt.levels=list())
+   Fitresults <- .Call("rlm_PLMset",pm(Dilution),mm(Dilution),probeNames(Dilution),length(geneNames(Dilution)),R.model,output,modelparam)
+   
+ #### store weights PMMM ~ -1 + samples + probe.type + probes
+ 
+   output <- verify.output.param(list(weights = TRUE, residuals = TRUE, varcov ="none", resid.SE = TRUE))
+   modelparam <- list(trans.fn="log2", se.type = 4, psi.type = 0, psi.k =1.345,max.its = 20, init.method = "ls",weights.chip=NULL,weights.probe=NULL)
+ 
+   
+   R.model <- list(mmorpm.covariate=0,response.variable=0,which.parameter.types=as.integer(c(0,0,1,1,1)),strata=as.integer(c(0,0,0,0,0)),constraints=as.integer(c(0,0,0,1,-1)),probe.type.trt.factor=NULL,max.probe.type.trt.factor=0,probe.trt.factor=NULL,max.probe.trt.factor=0,chipcovariates =matrix(0,0,0),probe.type.levels=list(),probe.trt.levels=list())
+   Fitresults <- .Call("rlm_PLMset",pm(Dilution),mm(Dilution),probeNames(Dilution),length(geneNames(Dilution)),R.model,output,modelparam)
+   
+   ## PM ~ -1 + treatment + probes in treatment
+   output <- verify.output.param(list(weights = TRUE, residuals = TRUE, varcov = "none", resid.SE = TRUE))
+   modelparam <- list(trans.fn="log2", se.type = 4, psi.type = 0, psi.k =1.345,max.its = 20, init.method = "ls",weights.chip=NULL,weights.probe=NULL)
+ 
+   treatment.effect <- c(1,1,2,2)
+ 
+   covariates <- model.matrix(~ -1 + as.factor(treatment.effect))
+ 
+   R.model <- list(mmorpm.covariate=0,response.variable=1,which.parameter.types=as.integer(c(0,1,0,0,1)),strata=as.integer(c(0,0,0,0,2)),constraints=as.integer(c(0,0,0,0,-1)),probe.type.trt.factor=NULL,max.probe.type.trt.factor=0,probe.trt.factor=as.integer(c(0,0,1,1)),max.probe.trt.factor=1,chipcovariates =covariates,probe.type.levels=list(),probe.trt.levels=list("blah"=c("A","B")))
+ 
+   Fitresults <- .Call("rlm_PLMset",pm(Dilution),mm(Dilution),probeNames(Dilution),length(geneNames(Dilution)),R.model,output,modelparam)
+ 
+   ## PMMM ~ -1 + treatment + probes in treatment
+   output <- list(weights = TRUE, residuals = TRUE, varcov = c("none","chiplevel", "all"), resid.SE = TRUE)
+   modelparam <- list(trans.fn="log2", se.type = 4, psi.type = 0, psi.k =1.345,max.its = 20, init.method = "ls",weights.chip=NULL,weights.probe=NULL)
+ 
+   treatment.effect <- c(1,1,2,2)
+ 
+   covariates <- model.matrix(~ -1 + as.factor(treatment.effect))
+ 
+   R.model <- list(mmorpm.covariate=0,response.variable=0,which.parameter.types=as.integer(c(0,1,0,0,1)),strata=as.integer(c(0,0,0,0,2)),constraints=as.integer(c(0,0,0,0,-1)),probe.type.trt.factor=NULL,max.probe.type.trt.factor=0,probe.trt.factor=as.integer(c(0,0,1,1)),max.probe.trt.factor=1,chipcovariates =covariates,probe.type.levels=list(),probe.trt.levels=list("blah"=c("A","B")))
+ 
+   Fitresults <- .Call("rlm_PLMset",pm(Dilution),mm(Dilution),probeNames(Dilution),length(geneNames(Dilution)),R.model,output,modelparam)
+   
+    ## PMMM ~ -1 + treatment + probe.effect in treatment
+   output <- list(weights = TRUE, residuals = TRUE, varcov = c("none","chiplevel", "all"), resid.SE = TRUE)
+   modelparam <- list(trans.fn="log2", se.type = 4, psi.type = 0, psi.k =1.345,max.its = 20, init.method = "ls",weights.chip=NULL,weights.probe=NULL)
+ 
+   treatment.effect <- c(1,1,2,2)
+ 
+   covariates <- model.matrix(~ -1 + as.factor(treatment.effect))
+ 
+   R.model <- list(mmorpm.covariate=0,response.variable=0,which.parameter.types=as.integer(c(0,1,0,1,0)),strata=as.integer(c(0,0,0,2,0)),constraints=as.integer(c(0,0,0,-1,0)),probe.type.trt.factor=as.integer(c(0,0,1,1)),max.probe.type.trt.factor=1,probe.trt.factor=as.integer(c(0,0,1,1)),max.probe.trt.factor=0,chipcovariates =covariates,probe.type.levels=list("blah"=c("A","B")),probe.trt.levels=list("blah"=c("A","B")))
+ 
+   Fitresults <- .Call("rlm_PLMset",pm(Dilution),mm(Dilution),probeNames(Dilution),length(geneNames(Dilution)),R.model,output,modelparam)
+   
+    ## PMMM ~ -1+ probes
+   output <- list(weights = TRUE, residuals = TRUE, varcov = c("none","chiplevel", "all"), resid.SE = TRUE)
+   modelparam <- list(trans.fn="log2", se.type = 4, psi.type = 0, psi.k =1.345,max.its = 20, init.method = "ls",weights.chip=NULL,weights.probe=NULL)
+ 
+   R.model <- list(mmorpm.covariate=0,response.variable=0,which.parameter.types=as.integer(c(0,0,0,0,1)),strata=as.integer(c(0,0,0,0,0)),constraints=as.integer(c(0,0,0,0,0)),probe.type.trt.factor=NULL,max.probe.type.trt.factor=0,probe.trt.factor=NULL,max.probe.trt.factor=0,chipcovariates =matrix(0,0,0),probe.type.levels=list(),probe.trt.levels=list())
+ 
+   Fitresults <- .Call("rlm_PLMset",pm(Dilution),mm(Dilution),probeNames(Dilution),length(geneNames(Dilution)),R.model,output,modelparam)
+   
+    ## PMMM ~ -1+ probes.type
+   output <- list(weights = TRUE, residuals = TRUE, varcov = c("none","chiplevel", "all"), resid.SE = TRUE)
+   modelparam <- list(trans.fn="log2", se.type = 4, psi.type = 0, psi.k =1.345,max.its = 20, init.method = "ls",weights.chip=NULL,weights.probe=NULL)
+ 
+   R.model <- list(mmorpm.covariate=0,response.variable=0,which.parameter.types=as.integer(c(0,0,0,1,0)),strata=as.integer(c(0,0,0,0,0)),constraints=as.integer(c(0,0,0,0,0)),probe.type.trt.factor=NULL,max.probe.type.trt.factor=0,probe.trt.factor=NULL,max.probe.trt.factor=0,chipcovariates =matrix(0,0,0),probe.type.levels=list(),probe.trt.levels=list())
+ 
+   Fitresults <- .Call("rlm_PLMset",pm(Dilution),mm(Dilution),probeNames(Dilution),length(geneNames(Dilution)),R.model,output,modelparam)
+ 
+   ## PMMM ~ -1+ probes.type + probes
+   output <- list(weights = TRUE, residuals = TRUE, varcov = c("none","chiplevel", "all"), resid.SE = TRUE)
+   modelparam <- list(trans.fn="log2", se.type = 4, psi.type = 0, psi.k =1.345,max.its = 20, init.method = "ls",weights.chip=NULL,weights.probe=NULL)
+ 
+   R.model <- list(mmorpm.covariate=0,response.variable=0,which.parameter.types=as.integer(c(0,0,0,1,1)),strata=as.integer(c(0,0,0,0,0)),constraints=as.integer(c(0,0,0,0,-1)),probe.type.trt.factor=NULL,max.probe.type.trt.factor=0,probe.trt.factor=NULL,max.probe.trt.factor=0,chipcovariates =matrix(0,0,0),probe.type.levels=list(),probe.trt.levels=list())
+ 
+   Fitresults <- .Call("rlm_PLMset",pm(Dilution),mm(Dilution),probeNames(Dilution),length(geneNames(Dilution)),R.model,output,modelparam)
+ 
+     ## PMMM ~ -1+ probes.type + probes     with both within treatment factor
+   output <- list(weights = TRUE, residuals = TRUE, varcov = c("none","chiplevel", "all"), resid.SE = TRUE)
+   modelparam <- list(trans.fn="log2", se.type = 4, psi.type = 0, psi.k =1.345,max.its = 20, init.method = "ls",weights.chip=NULL,weights.probe=NULL)
+ 
+   R.model <- list(mmorpm.covariate=0,response.variable=0,which.parameter.types=as.integer(c(0,0,0,1,1)),strata=as.integer(c(0,0,0,2,2)),constraints=as.integer(c(0,0,0,0,-1)),probe.type.trt.factor=as.integer(c(0,0,1,1)),max.probe.type.trt.factor=1,probe.trt.factor=as.integer(c(0,0,1,1)),max.probe.trt.factor=1,chipcovariates =matrix(0,0,0),probe.type.levels=list("blah"=c("A","B")),probe.trt.levels=list("blah"=c("A","B")))
+ 
+   Fitresults <- .Call("rlm_PLMset",pm(Dilution),mm(Dilution),probeNames(Dilution),length(geneNames(Dilution)),R.model,output,modelparam)
+ 
+ 
+     ## PMMM ~ -1+ probes.type + probes     with both within treatment factor and probes also within probe.type
+   output <- list(weights = TRUE, residuals = TRUE, varcov = c("none","chiplevel", "all"), resid.SE = TRUE)
+   modelparam <- list(trans.fn="log2", se.type = 4, psi.type = 0, psi.k =1.345,max.its = 20, init.method = "ls",weights.chip=NULL,weights.probe=NULL)
+ 
+   R.model <- list(mmorpm.covariate=0,response.variable=0,which.parameter.types=as.integer(c(0,0,0,1,1)),strata=as.integer(c(0,0,0,2,4)),constraints=as.integer(c(0,0,0,0,-1)),probe.type.trt.factor=as.integer(c(0,0,1,1)),max.probe.type.trt.factor=1,probe.trt.factor=as.integer(c(0,0,1,1)),max.probe.trt.factor=1,chipcovariates =matrix(0,0,0),probe.type.levels=list("blah"=c("A","B")),probe.trt.levels=list("blah"=c("A","B")))
+ 
+   Fitresults <- .Call("rlm_PLMset",pm(Dilution),mm(Dilution),probeNames(Dilution),length(geneNames(Dilution)),R.model,output,modelparam)
+ 
+ 
+   ## PMMM ~ -1+ probes.type + probes     probe.types within treatment factor and probes also within probe.type
+   output <- list(weights = TRUE, residuals = TRUE, varcov = c("none","chiplevel", "all"), resid.SE = TRUE)
+   modelparam <- list(trans.fn="log2", se.type = 4, psi.type = 0, psi.k =1.345,max.its = 20, init.method = "ls",weights.chip=NULL,weights.probe=NULL)
+ 
+   R.model <- list(mmorpm.covariate=0,response.variable=0,which.parameter.types=as.integer(c(0,0,0,1,1)),strata=as.integer(c(0,0,0,2,3)),constraints=as.integer(c(0,0,0,0,-1)),probe.type.trt.factor=as.integer(c(0,0,1,1)),max.probe.type.trt.factor=1,probe.trt.factor=as.integer(c(0,0,1,1)),max.probe.trt.factor=1,chipcovariates =matrix(0,0,0),probe.type.levels=list("blah"=c("A","B")),probe.trt.levels=list("blah"=c("A","B")))
+ 
+   Fitresults <- .Call("rlm_PLMset",pm(Dilution),mm(Dilution),probeNames(Dilution),length(geneNames(Dilution)),R.model,output,modelparam)
+ 
+  ## PMMM ~ -1+ probes.type + probes     probe.types within samples and probes also within probe.type
+   output <- list(weights = TRUE, residuals = TRUE, varcov = c("none","chiplevel", "all"), resid.SE = TRUE)
+   modelparam <- list(trans.fn="log2", se.type = 4, psi.type = 0, psi.k =1.345,max.its = 20, init.method = "ls",weights.chip=NULL,weights.probe=NULL)
+ 
+   R.model <- list(mmorpm.covariate=0,response.variable=0,which.parameter.types=as.integer(c(0,0,0,1,1)),strata=as.integer(c(0,0,0,1,3)),constraints=as.integer(c(0,0,0,0,-1)),probe.type.trt.factor=as.integer(c(0,0,1,1)),max.probe.type.trt.factor=1,probe.trt.factor=as.integer(c(0,0,1,1)),max.probe.trt.factor=1,chipcovariates =matrix(0,0,0),probe.type.levels=list("blah"=c("A","B")),probe.trt.levels=list("blah"=c("A","B")))
+ 
+   Fitresults <- .Call("rlm_PLMset",pm(Dilution),mm(Dilution),probeNames(Dilution),length(geneNames(Dilution)),R.model,output,modelparam)
+ 
+ 
+ 
+   ## PMMM ~ intercept + probes.type + probes     probe.types within samples and probes also within probe.type
+   output <- list(weights = TRUE, residuals = TRUE, varcov = c("none","chiplevel", "all"), resid.SE = TRUE)
+   modelparam <- list(trans.fn="log2", se.type = 4, psi.type = 0, psi.k =1.345,max.its = 20, init.method = "ls",weights.chip=NULL,weights.probe=NULL)
+   
+   R.model <- list(mmorpm.covariate=0,response.variable=0,which.parameter.types=as.integer(c(1,0,0,1,1)),strata=as.integer(c(0,0,0,1,3)),constraints=as.integer(c(0,0,0,-1,-1)),probe.type.trt.factor=as.integer(c(0,0,1,1)),max.probe.type.trt.factor=1,probe.trt.factor=as.integer(c(0,0,1,1)),max.probe.trt.factor=1,chipcovariates =matrix(0,0,0),probe.type.levels=list("blah"=c("A","B")),probe.trt.levels=list("blah"=c("A","B")))
+   
+   Fitresults <- .Call("rlm_PLMset",pm(Dilution),mm(Dilution),probeNames(Dilution),length(geneNames(Dilution)),R.model,output,modelparam)
+ 
+     ## PMMM ~ intercept + probes      probes also within probe.type
+   output <- list(weights = TRUE, residuals = TRUE, varcov = c("none","chiplevel", "all"), resid.SE = TRUE)
+   modelparam <- list(trans.fn="log2", se.type = 4, psi.type = 0, psi.k =1.345,max.its = 20, init.method = "ls",weights.chip=NULL,weights.probe=NULL)
+   
+   R.model <- list(mmorpm.covariate=0,response.variable=0,which.parameter.types=as.integer(c(1,0,0,0,1)),strata=as.integer(c(0,0,0,0,3)),constraints=as.integer(c(0,0,0,0,-1)),probe.type.trt.factor=as.integer(c(0,0,1,1)),max.probe.type.trt.factor=1,probe.trt.factor=as.integer(c(0,0,1,1)),max.probe.trt.factor=1,chipcovariates =matrix(0,0,0),probe.type.levels=list("blah"=c("A","B")),probe.trt.levels=list("blah"=c("A","B")))
+   
+   Fitresults <- .Call("rlm_PLMset",pm(Dilution),mm(Dilution),probeNames(Dilution),length(geneNames(Dilution)),R.model,output,modelparam)
+ 
+      ## PMMM ~ -1+ probes      probes also within probe.type
+   output <- list(weights = TRUE, residuals = TRUE, varcov = c("none","chiplevel", "all"), resid.SE = TRUE)
+   modelparam <- list(trans.fn="log2", se.type = 4, psi.type = 0, psi.k =1.345,max.its = 20, init.method = "ls",weights.chip=NULL,weights.probe=NULL)
+   
+   R.model <- list(mmorpm.covariate=0,response.variable=0,which.parameter.types=as.integer(c(0,0,0,0,1)),strata=as.integer(c(0,0,0,0,3)),constraints=as.integer(c(0,0,0,0,0)),probe.type.trt.factor=as.integer(c(0,0,1,1)),max.probe.type.trt.factor=1,probe.trt.factor=as.integer(c(0,0,1,1)),max.probe.trt.factor=1,chipcovariates =matrix(0,0,0),probe.type.levels=list("blah"=c("A","B")),probe.trt.levels=list("blah"=c("A","B")))
+   
+   Fitresults <- .Call("rlm_PLMset",pm(Dilution),mm(Dilution),probeNames(Dilution),length(geneNames(Dilution)),R.model,output,modelparam)
+ 
+   # now play with varcov output
+   output <- list(weights = TRUE, residuals = TRUE, varcov ="chiplevel", resid.SE = TRUE)
+   modelparam <- list(trans.fn="log2", se.type = 4, psi.type = 0, psi.k =1.345,max.its = 20, init.method = "ls",weights.chip=NULL,weights.probe=NULL)
+   
+   R.model <- list(mmorpm.covariate=0,response.variable=0,which.parameter.types=as.integer(c(0,0,1,0,1)),strata=as.integer(c(0,0,0,0,0)),constraints=as.integer(c(0,0,0,0,-1)),probe.type.trt.factor=as.integer(c(0,0,1,1)),max.probe.type.trt.factor=1,probe.trt.factor=as.integer(c(0,0,1,1)),max.probe.trt.factor=1,chipcovariates =matrix(0,0,0),probe.type.levels=list("blah"=c("A","B")),probe.trt.levels=list("blah"=c("A","B")))
+   
+   Fitresults <- .Call("rlm_PLMset",pm(Dilution),mm(Dilution),probeNames(Dilution),length(geneNames(Dilution)),R.model,output,modelparam)
+ 
+  # now play with varcov output and treatment
+   output <- list(weights = TRUE, residuals = TRUE, varcov ="chiplevel", resid.SE = TRUE)
+   modelparam <- list(trans.fn="log2", se.type = 4, psi.type = 0, psi.k =1.345,max.its = 20, init.method = "ls",weights.chip=NULL,weights.probe=NULL)
+   
+  treatment.effect <- c(1,1,2,2)
+ 
+   covariates <- model.matrix(~ -1 + as.factor(treatment.effect))
+ 
+   R.model <- list(mmorpm.covariate=0,response.variable=0,which.parameter.types=as.integer(c(0,1,0,0,0)),strata=as.integer(c(0,0,0,2,0)),constraints=as.integer(c(0,0,0,0,0)),probe.type.trt.factor=as.integer(c(0,0,1,1)),max.probe.type.trt.factor=1,probe.trt.factor=as.integer(c(0,0,1,1)),max.probe.trt.factor=0,chipcovariates =covariates,probe.type.levels=list("blah"=c("A","B")),probe.trt.levels=list("blah"=c("A","B")))
+ 
+   Fitresults <- .Call("rlm_PLMset",pm(Dilution),mm(Dilution),probeNames(Dilution),length(geneNames(Dilution)),R.model,output,modelparam)
+ 
+   
+ 
+   # now play with varcov output and an intercept
+   output <- list(weights = TRUE, residuals = TRUE, varcov ="chiplevel", resid.SE = TRUE)
+   modelparam <- list(trans.fn="log2", se.type = 4, psi.type = 0, psi.k =1.345,max.its = 20, init.method = "ls",weights.chip=NULL,weights.probe=NULL)
+   
+   R.model <- list(mmorpm.covariate=0,response.variable=0,which.parameter.types=as.integer(c(1,0,1,0,1)),strata=as.integer(c(0,0,0,0,0)),constraints=as.integer(c(0,0,-1,0,-1)),probe.type.trt.factor=as.integer(c(0,0,1,1)),max.probe.type.trt.factor=1,probe.trt.factor=as.integer(c(0,0,1,1)),max.probe.trt.factor=1,chipcovariates =matrix(0,0,0),probe.type.levels=list("blah"=c("A","B")),probe.trt.levels=list("blah"=c("A","B")))
+   
+   Fitresults <- .Call("rlm_PLMset",pm(Dilution),mm(Dilution),probeNames(Dilution),length(geneNames(Dilution)),R.model,output,modelparam)
+ 
+ 
+ 
+  # now play with varcov output and treatment and intercept
+   output <- list(weights = TRUE, residuals = TRUE, varcov ="chiplevel", resid.SE = TRUE)
+   modelparam <- list(trans.fn="log2", se.type = 4, psi.type = 0, psi.k =1.345,max.its = 20, init.method = "ls",weights.chip=NULL,weights.probe=NULL)
+   
+  treatment.effect <- c(1,1,2,2)
+ 
+   covariates <- matrix(model.matrix(~ as.factor(treatment.effect))[,2])
+   colnames(covariates) <- "trt_2"
+ 
+   R.model <- list(mmorpm.covariate=0,response.variable=0,which.parameter.types=as.integer(c(1,1,0,0,0)),strata=as.integer(c(0,0,0,2,0)),constraints=as.integer(c(0,0,0,0,0)),probe.type.trt.factor=as.integer(c(0,0,1,1)),max.probe.type.trt.factor=1,probe.trt.factor=as.integer(c(0,0,1,1)),max.probe.trt.factor=0,chipcovariates =covariates,probe.type.levels=list("blah"=c("A","B")),probe.trt.levels=list("blah"=c("A","B")))
+ 
+   Fitresults <- .Call("rlm_PLMset",pm(Dilution),mm(Dilution),probeNames(Dilution),length(geneNames(Dilution)),R.model,output,modelparam)
+ 
+   
+ 
+  # now play with varcov all option output and treatment and intercept
+   output <- list(weights = TRUE, residuals = TRUE, varcov ="all", resid.SE = TRUE)
+   modelparam <- list(trans.fn="log2", se.type = 4, psi.type = 0, psi.k =1.345,max.its = 20, init.method = "ls",weights.chip=NULL,weights.probe=NULL)
+   
+  treatment.effect <- c(1,1,2,2)
+    
+   covariates <- matrix(model.matrix(~ as.factor(treatment.effect))[,2])
+   colnames(covariates) <- "trt_2"
+   R.model <- list(mmorpm.covariate=0,response.variable=0,which.parameter.types=as.integer(c(1,1,0,0,0)),strata=as.integer(c(0,0,0,2,0)),constraints=as.integer(c(0,0,0,0,0)),probe.type.trt.factor=as.integer(c(0,0,1,1)),max.probe.type.trt.factor=1,probe.trt.factor=as.integer(c(0,0,1,1)),max.probe.trt.factor=0,chipcovariates =covariates,probe.type.levels=list("blah"=c("A","B")),probe.trt.levels=list("blah"=c("A","B")))
+ 
+   Fitresults <- .Call("rlm_PLMset",pm(Dilution),mm(Dilution),probeNames(Dilution),length(geneNames(Dilution)),R.model,output,modelparam)
+ 
+  # now play with varcov all option output and samples and intercept
+   output <- list(weights = TRUE, residuals = TRUE, varcov ="all", resid.SE = TRUE)
+   modelparam <- list(trans.fn="log2", se.type = 4, psi.type = 0, psi.k =1.345,max.its = 20, init.method = "ls",weights.chip=NULL,weights.probe=NULL)
+   
+   R.model <- list(mmorpm.covariate=0,response.variable=0,which.parameter.types=as.integer(c(1,0,1,0,1)),strata=as.integer(c(0,0,0,2,0)),constraints=as.integer(c(0,0,-1,0,-1)),probe.type.trt.factor=as.integer(c(0,0,1,1)),max.probe.type.trt.factor=1,probe.trt.factor=as.integer(c(0,0,1,1)),max.probe.trt.factor=0,chipcovariates =matrix(0,0,0),probe.type.levels=list("blah"=c("A","B")),probe.trt.levels=list("blah"=c("A","B")))
+ 
+   Fitresults <- .Call("rlm_PLMset",pm(Dilution),mm(Dilution),probeNames(Dilution),length(geneNames(Dilution)),R.model,output,modelparam)
+ 
+        # now play with varcov all option output and samples and intercept, MM covarite
+     output <- list(weights = TRUE, residuals = TRUE, varcov ="all", resid.SE = TRUE)
+   modelparam <- list(trans.fn="log2", se.type = 4, psi.type = 0, psi.k =1.345,max.its = 20, init.method = "ls",weights.chip=NULL,weights.probe=NULL)
+   
+   R.model <- list(mmorpm.covariate=1,response.variable=1,which.parameter.types=as.integer(c(1,0,1,0,1)),strata=as.integer(c(0,0,0,2,0)),constraints=as.integer(c(0,0,-1,0,-1)),probe.type.trt.factor=as.integer(c(0,0,1,1)),max.probe.type.trt.factor=1,probe.trt.factor=as.integer(c(0,0,1,1)),max.probe.trt.factor=0,chipcovariates =matrix(0,0,0),probe.type.levels=list("blah"=c("A","B")),probe.trt.levels=list("blah"=c("A","B")))
+ 
+   Fitresults <- .Call("rlm_PLMset",pm(Dilution),mm(Dilution),probeNames(Dilution),length(geneNames(Dilution)),R.model,output,modelparam)
+ 
+ 
+ 
+ 
+ 
+ 
+ 
+   ## now play with varcov all option output and samples and intercept, MM covariate and input chip weights
+   output <- verify.output.param(list(weights = TRUE, residuals = TRUE, varcov ="all", resid.SE = TRUE))
+   modelparam <- list(trans.fn="log2", se.type = 4, psi.type = 0, psi.k =1.345,max.its = 20, init.method = "ls",weights.chip=c(1,1,0.5,0.5),weights.probe=NULL)
+   
+   R.model <- list(mmorpm.covariate=0,response.variable=1,which.parameter.types=as.integer(c(0,0,1,0,1)),strata=as.integer(c(0,0,0,2,0)),constraints=as.integer(c(0,0,0,0,-1)),probe.type.trt.factor=as.integer(c(0,0,1,1)),max.probe.type.trt.factor=1,probe.trt.factor=as.integer(c(0,0,1,1)),max.probe.trt.factor=0,chipcovariates =matrix(0,0,0),probe.type.levels=list("blah"=c("A","B")),probe.trt.levels=list("blah"=c("A","B")))
+ 
+   Fitresults <- .Call("rlm_PLMset",pm(Dilution),mm(Dilution),probeNames(Dilution),length(geneNames(Dilution)),R.model,output,modelparam)
+ 
+   ## now play with varcov all option output and samples and intercept, MM covariate and input chip weights
+   output <- list(weights = TRUE, residuals = TRUE, varcov ="all", resid.SE = TRUE)
+   modelparam <- list(trans.fn="log2", se.type = 4, psi.type = 0, psi.k =1.345,max.its = 20, init.method = "ls",weights.chip=NULL,weights.probe=runif(201800))
+   
+   R.model <- list(mmorpm.covariate=0,response.variable=1,which.parameter.types=as.integer(c(0,0,1,0,1)),strata=as.integer(c(0,0,0,2,0)),constraints=as.integer(c(0,0,0,0,-1)),probe.type.trt.factor=as.integer(c(0,0,1,1)),max.probe.type.trt.factor=1,probe.trt.factor=as.integer(c(0,0,1,1)),max.probe.trt.factor=0,chipcovariates =matrix(0,0,0),probe.type.levels=list("blah"=c("A","B")),probe.trt.levels=list("blah"=c("A","B")))
+ 
+   Fitresults <- .Call("rlm_PLMset",pm(Dilution),mm(Dilution),probeNames(Dilution),length(geneNames(Dilution)),R.model,output,modelparam)
+ 
+ 
+ 
+   output <- list(weights = TRUE, residuals = TRUE, varcov ="all", resid.SE = TRUE)
+   modelparam <- list(trans.fn="log2", se.type = 4, psi.type = 0, psi.k =1.345,max.its = 20, init.method = "ls",weights.chip=NULL,weights.probe=c(rep(c(1,0.5),c(201800,201800))))
+   
+   R.model <- list(mmorpm.covariate=0,response.variable=0,which.parameter.types=as.integer(c(0,0,1,0,1)),strata=as.integer(c(0,0,0,2,0)),constraints=as.integer(c(0,0,0,0,-1)),probe.type.trt.factor=as.integer(c(0,0,1,1)),max.probe.type.trt.factor=1,probe.trt.factor=as.integer(c(0,0,1,1)),max.probe.trt.factor=0,chipcovariates =matrix(0,0,0),probe.type.levels=list("blah"=c("A","B")),probe.trt.levels=list("blah"=c("A","B")))
+ 
+   Fitresults <- .Call("rlm_PLMset",pm(Dilution),mm(Dilution),probeNames(Dilution),length(geneNames(Dilution)),R.model,output,modelparam)
+   
+   
+ 
+   output <- list(weights = TRUE, residuals = TRUE, varcov ="all", resid.SE = TRUE)
+   modelparam <- list(trans.fn="cuberoot", se.type = 4, psi.type = 0, psi.k =1.345,max.its = 20, init.method = "ls",weights.chip=NULL,weights.probe=NULL)
+   
+   R.model <- list(mmorpm.covariate=0,response.variable=0,which.parameter.types=as.integer(c(0,0,1,0,1)),strata=as.integer(c(0,0,0,2,0)),constraints=as.integer(c(0,0,0,0,-1)),probe.type.trt.factor=as.integer(c(0,0,1,1)),max.probe.type.trt.factor=1,probe.trt.factor=as.integer(c(0,0,1,1)),max.probe.trt.factor=0,chipcovariates =matrix(0,0,0),probe.type.levels=list("blah"=c("A","B")),probe.trt.levels=list("blah"=c("A","B")))
+ 
+   Fitresults <- .Call("rlm_PLMset",pm(Dilution),mm(Dilution),probeNames(Dilution),length(geneNames(Dilution)),R.model,output,modelparam)
+   
+   
+ 
+   output <- list(weights = TRUE, residuals = TRUE, varcov ="all", resid.SE = TRUE)
+   modelparam <- list(trans.fn="log10", se.type = 4, psi.type = 0, psi.k =1.345,max.its = 20, init.method = "ls",weights.chip=NULL,weights.probe=NULL)
+   
+   R.model <- list(mmorpm.covariate=0,response.variable=0,which.parameter.types=as.integer(c(0,0,1,0,1)),strata=as.integer(c(0,0,0,2,0)),constraints=as.integer(c(0,0,0,0,-1)),probe.type.trt.factor=as.integer(c(0,0,1,1)),max.probe.type.trt.factor=1,probe.trt.factor=as.integer(c(0,0,1,1)),max.probe.trt.factor=0,chipcovariates =matrix(0,0,0),probe.type.levels=list("blah"=c("A","B")),probe.trt.levels=list("blah"=c("A","B")))
+ 
+   Fitresults <- .Call("rlm_PLMset",pm(Dilution),mm(Dilution),probeNames(Dilution),length(geneNames(Dilution)),R.model,output,modelparam)
+   
+ }
> 
> 
> 
> if (test.PLM.modelmatrix){
+ 
+   library(affyPLM);data(Dilution)
+   
+   #PLM.designmatrix3(Dilution)
+   
+   #PLM.designmatrix3(Dilution,model=MM ~ PM -1 + samples +probe.type:probes)
+   
+   #PLM.designmatrix3(Dilution,model=MM ~ PM -1 + samples:probe.type + liver:probe.type:probes + liver:samples)
+   #PLM.designmatrix3(Dilution,model=MM ~ PM + samples:probe.type + liver:probe.type:probes + liver + samples)
+ 
+ 
+ 
+ 
+   output <- list(weights = TRUE, residuals = TRUE, varcov ="all", resid.SE = TRUE)
+   modelparam <- list(trans.fn="log2", se.type = 4, psi.type = 0, psi.k =1.345,max.its = 20, init.method = "ls",weights.chip=NULL,weights.probe=NULL)
+   #blah <- c(1,5,5,1)
+   #R.model <- PLM.designmatrix3(Dilution,model=PMMM ~ probes + blah,constraint.type=c(probes="contr.sum"))
+   #R.model <- PLM.designmatrix3(Dilution,model=PMMM ~ -1 + blah:probe.type)
+   #R.model <- PLM.designmatrix3(Dilution,model=PMMM ~ -1 +probes:probe.type)
+   #R.model <- PLM.designmatrix3(Dilution,model=PMMM ~ -1 +probes:blah)
+   #R.model <- PLM.designmatrix3(Dilution,model=PMMM ~ -1 +probes:probe.type:blah)
+   #output <- list(weights = TRUE, residuals = TRUE, varcov ="chiplevel", resid.SE = TRUE)
+ #  R.model <- PLM.designmatrix3(Dilution,model=PMMM ~ samples,constraint.type=c(samples="contr.sum"))
+ #  R.model <-  PLM.designmatrix3(Dilution,model=PMMM ~ blah)
+ #   R.model <- PLM.designmatrix3(Dilution,model=PMMM ~ -1 + samples)
+   #R.model <- PLM.designmatrix3(Dilution,model=PMMM ~ probes + blah)
+   #R.model <- PLM.designmatrix3(Dilution,model=PMMM ~ probes + blah)
+   #Fitresults <- .Call("rlm_PLMset",pm(Dilution),mm(Dilution),probeNames(Dilution),length(geneNames(Dilution)),R.model,output,modelparam)
+ 
+   library(affyPLM);data(Dilution)
+    output <- list(weights = TRUE, residuals = TRUE, varcov ="chiplevel", resid.SE = TRUE)
+   modelparam <- list(trans.fn="log2", se.type = 4, psi.type = 0, psi.k =1.345,max.its = 20, init.method = "ls",weights.chip=NULL,weights.probe=NULL)
+   R.model <- PLM.designmatrix3(Dilution,model=PMMM ~ probe.type + probe.type:probes + samples)
+   Fitresults <- .Call("rlm_PLMset",pm(Dilution),mm(Dilution),probeNames(Dilution),length(geneNames(Dilution)),R.model,output,modelparam)
+ 
+   library(affyPLM);data(Dilution)
+   output <- list(weights = TRUE, residuals = TRUE, varcov ="chiplevel", resid.SE = TRUE)
+   modelparam <- list(trans.fn="log2", se.type = 4, psi.type = 0, psi.k =1.345,max.its = 20, init.method = "ls",weights.chip=NULL,weights.probe=NULL)
+   R.model <- PLM.designmatrix3(Dilution,model=PMMM ~ samples:probe.type + probe.type:probes + samples)
+   Fitresults <- .Call("rlm_PLMset",pm(Dilution),mm(Dilution),probeNames(Dilution),length(geneNames(Dilution)),R.model,output,modelparam)
+   
+   
+  output <- list(weights = TRUE, residuals = TRUE, varcov ="chiplevel", resid.SE = TRUE)
+   modelparam <- list(trans.fn="log2", se.type = 4, psi.type = 0, psi.k =1.345,max.its = 20, init.method = "ls",weights.chip=NULL,weights.probe=NULL)
+   blah <- c(1,2,2)
+   R.model <- PLM.designmatrix3(Dilution,model=PMMM ~ blah:probe.type + probe.type:probes + samples)
+   Fitresults <- .Call("rlm_PLMset",pm(Dilution),mm(Dilution),probeNames(Dilution),length(geneNames(Dilution)),R.model,output,modelparam)
+ 
+   
+   output <- list(weights = TRUE, residuals = TRUE, varcov ="all", resid.SE = TRUE)
+   modelparam <- list(trans.fn="log2", se.type = 4, psi.type = 0, psi.k =1.345,max.its = 20, init.method = "ls",weights.chip=NULL,weights.probe=NULL)
+   blah <- c(1,2,2)
+   R.model <- PLM.designmatrix3(Dilution,model=PM ~ -1 + probes + MM + blah)
+   Fitresults <- .Call("rlm_PLMset",pm(Dilution),mm(Dilution),probeNames(Dilution),length(geneNames(Dilution)),R.model,output,modelparam)
+ 
+   
+   output <- list(weights = TRUE, residuals = TRUE, varcov ="all", resid.SE = TRUE)
+   modelparam <- list(trans.fn="log2", se.type = 4, psi.type = 0, psi.k =1.345,max.its = 20, init.method = "ls",weights.chip=NULL,weights.probe=NULL)
+   blah <- c(1,2,2)
+   R.model <- PLM.designmatrix3(Dilution,model=PM ~ -1 + probes + MM + samples)
+   Fitresults <- .Call("rlm_PLMset",pm(Dilution),mm(Dilution),probeNames(Dilution),length(geneNames(Dilution)),R.model,output,modelparam)
+   
+ 
+ 
+ 
+ 
+ #test some of the verification functions
+ 
+ 
+   output <- verify.output.param()
+   modelparam <- verify.model.param(Dilution,PM ~ -1 + probes + MM + samples)
+   R.model <- PLM.designmatrix3(Dilution,model=PM ~ -1 + probes + MM + samples)
+  
+   Fitresults <- .Call("rlm_PLMset",pm(Dilution),mm(Dilution),probeNames(Dilution),length(geneNames(Dilution)),R.model,output,modelparam)
+   
+   ##verify.model.param(Dilution,PM ~ -1 + probes + MM + samples,model.param=list(weights.probe=rep(1,10)))
+ 
+    modelparam <- verify.model.param(Dilution,PMMM ~ -1 + probes + samples,model.param=list(weights.chip=c(1,2,3),weights.probe=rep(1,2400*2)))
+   R.model <- PLM.designmatrix3(Dilution,model=PMMM ~ -1 + probes + samples)
+   Fitresults <- .Call("rlm_PLMset",pm(Dilution),mm(Dilution),probeNames(Dilution),length(geneNames(Dilution)),R.model,output,modelparam)
+ 
+ 
+   
+  modelparam <- verify.model.param(Dilution,PM ~ -1 + probes + samples,model.param=list())
+   R.model <- PLM.designmatrix3(Dilution,model=PM ~ -1 + probes + samples)
+   Fitresults <- .Call("rlm_PLMset",pm(Dilution),mm(Dilution),probeNames(Dilution),length(geneNames(Dilution)),R.model,output,modelparam)
+   ## probes <- rep(1:16,3)
+   ##  chips <- rep(1:3,c(16,16,16))
+ 
+   ## library(MASS)
+   
+   ##fit <- rlm(log2(as.vector(pm(Dilution,"HG2188-HT2258_at"))) ~ -1 + as.factor(chips) + C(as.factor(probes),"contr.sum"))
+   
+ 
+ #test creating a PLMset based on the output from rlm_PLMset
+ 
+ ###  x <- new("PLMset")
+ ###  x@chip.coefs=Fitresults[[1]]
+ ###  x@probe.coefs= Fitresults[[2]]
+ ###  x@weights=Fitresults[[3]]
+ ###  x@se.chip.coefs=Fitresults[[4]]
+ ###  x@se.probe.coefs=Fitresults[[5]]
+ ###  x@exprs=Fitresults[[6]]
+ ###  x@se.exprs=Fitresults[[7]]
+ ###  x@residuals=Fitresults[[8]]
+ ###  x@residualSE=Fitresults[[9]]
+ ###  x@varcov = Fitresults[[10]]
+ ###  x@cdfName = Dilution@cdfName
+  ### x@phenoData = Dilution@phenoData
+  ### x@annotation = Dilution@annotation
+ ###  x@description = Dilution@description
+ ###  x@notes = Dilution@notes
+ ###  x@nrow= Dilution@nrow
+ ###  x@ncol= Dilution@ncol
+ ### x@model.description = c(x@model.description, list(R.model=R.model))
+ ###  image(x)
+ 
+ 
+ 
+ 
+ ###  data(Dilution)
+ ###  output <- verify.output.param()
+ ###  modelparam <- verify.model.param(Dilution,PMMM ~ -1 + probe.type:probes + samples + samples:probe.type,model.param=list())
+ ###  R.model <- PLM.designmatrix3(Dilution,model=PMMM ~ -1 + probe.type:probes + samples+ samples:probe.type)
+ ###  Fitresults <- .Call("rlm_PLMset",pm(Dilution),mm(Dilution),probeNames(Dilution),length(geneNames(Dilution)),R.model,output,modelparam)
+ ###  output <- verify.output.param()
+ ###  modelparam <- verify.model.param(Dilution,MM ~ -1 + probes + samples,model.param=list())
+ ###  R.model <- PLM.designmatrix3(Dilution,model=MM ~ -1 + probes + samples)
+ ###  Fitresults <- .Call("rlm_PLMset",pm(Dilution),mm(Dilution),probeNames(Dilution),length(geneNames(Dilution)),R.model,output,modelparam)
+   
+   
+ 
+ ###  x <- new("PLMset")
+  ### x@chip.coefs=Fitresults[[1]]
+ ###  x@probe.coefs= Fitresults[[2]]
+ ###  x@weights=Fitresults[[3]]
+ ###  x@se.chip.coefs=Fitresults[[4]]
+ ###  x@se.probe.coefs=Fitresults[[5]]
+ ###  x@exprs=Fitresults[[6]]
+ ###  x@se.exprs=Fitresults[[7]]
+  ### x@residuals=Fitresults[[8]]
+ ###  x@residualSE=Fitresults[[9]]
+ ###  x@varcov = Fitresults[[10]]
+ ###  x@cdfName = Dilution@cdfName
+ ###  x@phenoData = Dilution@phenoData
+ ###  x@annotation = Dilution@annotation
+ ###  x@description = Dilution@description
+ ###  x@notes = Dilution@notes
+ ###  x@nrow= Dilution@nrow
+ ###  x@ncol= Dilution@ncol
+ ###  x@model.description = c(x@model.description, list(R.model=R.model))
+ ###  image(x)
+ ###  image(x,type="pos.resids")
+ ###  image(x,type="neg.resids")
+ ###  image(x,type="sign.resids")
+ 
+ ###  resid(x,"1091_at")
+ 
+ 
+ 
+ ###  weights(x,c("1091_at","1092_at"))
+ 
+ 
+ ###  image(x,type="resids",standardize=TRUE)
+ 
+ 
+ 
+ 
+   
+   
+ }
> 
> 
> 
> 
> 
> if (test.rlm){
+ 
+ 
+   library(affyPLM);data(Dilution)
+ 
+   y <- as.vector(log2(pm(Dilution)[1:16,]))
+ 
+   w <- runif(64)
+ 
+   probes <- rep(1:16,4)
+   samples <- rep(1:4,c(16,16,16,16))
+ 
+   x <- model.matrix( ~ -1 + as.factor(samples) + C(as.factor(probes),"contr.sum"))
+   x <- as.vector(x)
+ 
+   cols <- 19
+   rows <- 64
+   
+ 
+ #  rlm_wfit_R(double *x, double *y, double *w, int *rows, int *cols, double *out_beta, double *out_resids, double *out_weights)
+ 
+   fit1 <-.C("rlm_wfit_R",as.double(x),as.double(y),as.double(w),as.integer(rows),as.integer(cols),double(cols),double(rows),double(rows))
+ 
+ 
+   library(MASS)
+ 
+   fit2 <- rlm(y ~ -1 + as.factor(samples) + C(as.factor(probes),"contr.sum"),weights=w,wt.method="case")
+ 
+   if (any(abs(coef(fit2) - fit1[[6]]) > 10e-14)){
+     stop("Weighted RLM did not work")
+   }
+ 
+ 
+ 
+ 
+ 
+   y <- as.vector(log2(pm(Dilution,"1001_at")))
+   x <- as.vector(log2(mm(Dilution,"1001_at")))
+ 
+   rlm(y ~ -1 + x + as.factor(samples) + C(as.factor(probes),"contr.sum"))
+ 
+ 
+ 
+ 
+ 
+ 
+ 
+ 
+ 
+ 
+   
+ }
> 
> 
> 
> 
> proc.time()
   user  system elapsed 
   1.57    0.07    1.64 

R version 4.1.3 (2022-03-10) -- "One Push-Up"
Copyright (C) 2022 The R Foundation for Statistical Computing
Platform: x86_64-w64-mingw32/x64 (64-bit)

R is free software and comes with ABSOLUTELY NO WARRANTY.
You are welcome to redistribute it under certain conditions.
Type 'license()' or 'licence()' for distribution details.

R is a collaborative project with many contributors.
Type 'contributors()' for more information and
'citation()' on how to cite R or R packages in publications.

Type 'demo()' for some demos, 'help()' for on-line help, or
'help.start()' for an HTML browser interface to help.
Type 'q()' to quit R.

> ####
> #### This code is messy, possibly incomplete and only for
> #### the use of developers.
> ####
> ####
> 
> test.c.code <-  FALSE
> test.PLM.modelmatrix <- FALSE
> test.rlm <- FALSE
> 
> if (test.c.code){
+   
+   library(affyPLM)
+   narrays <- 10
+   nprobes <- 11
+   nprobetypes <- 2
+   ncols <- 10
+   
+   MMs <- rnorm(narrays*nprobes*nprobetypes)
+   X <- matrix(0,narrays*nprobes*nprobetypes,ncols)
+   
+                                         #test making intercept column
+   matrix(.C("R_PLM_matrix_intercept",as.double(as.vector(X)), as.integer(narrays),as.integer(nprobes),as.integer(nprobetypes),0)[[1]],ncol=10)
+   
+                                         #test making an MM covariate column
+   matrix(.C("R_PLM_matrix_MM",as.double(as.vector(X)), as.integer(narrays),as.integer(nprobes),as.integer(nprobetypes),as.integer(1),as.double(MMs))[[1]],ncol=10)
+   
+                                         # sample effect aka chip effect, aka expression values
+   matrix(.C("R_PLM_matrix_sample_effect",as.double(as.vector(X)), as.integer(narrays),as.integer(nprobes),as.integer(nprobetypes),as.integer(0),as.integer(0))[[1]],ncol=10)
+   matrix(.C("R_PLM_matrix_sample_effect",as.double(as.vector(X)), as.integer(narrays),as.integer(nprobes),as.integer(nprobetypes),as.integer(0),as.integer(1))[[1]],ncol=10)
+   matrix(.C("R_PLM_matrix_sample_effect",as.double(as.vector(X)), as.integer(narrays),as.integer(nprobes),as.integer(nprobetypes),as.integer(0),as.integer(-1))[[1]],ncol=10)
+   
+   
+   
+                                         #probe-type parameter overall
+   matrix(.C("R_PLM_matrix_probe_type_effect",as.double(as.vector(X)), as.integer(narrays),as.integer(nprobes),as.integer(nprobetypes),as.integer(0),as.integer(0),as.integer(0),integer(narrays),as.integer(1))[[1]],ncol=10)
+   
+                                         #probe-type parameter within sample
+   matrix(.C("R_PLM_matrix_probe_type_effect",as.double(as.vector(X)), as.integer(narrays),as.integer(nprobes),as.integer(nprobetypes),as.integer(0),as.integer(1),as.integer(1),integer(narrays),as.integer(1))[[1]],ncol=10)
+   matrix(.C("R_PLM_matrix_probe_type_effect",as.double(as.vector(X)), as.integer(narrays),as.integer(nprobes),as.integer(nprobetypes),as.integer(0),as.integer(-1),as.integer(1),integer(narrays),as.integer(1))[[1]],ncol=10)
+   ncols <- 20
+   X <- matrix(0,narrays*nprobes*nprobetypes,ncols)
+   matrix(.C("R_PLM_matrix_probe_type_effect",as.double(as.vector(X)), as.integer(narrays),as.integer(nprobes),as.integer(nprobetypes),as.integer(0),as.integer(0),as.integer(1),integer(narrays),as.integer(0))[[1]],ncol=20)
+   
+   
+                                         #probe-type-parameter within a chip-level factor (eg treatment, or genotype variable)
+   trt.cov <- rep(0:1,5)
+   ncols <- 10
+   X <- matrix(0,narrays*nprobes*nprobetypes,ncols)
+   matrix(.C("R_PLM_matrix_probe_type_effect",as.double(as.vector(X)), as.integer(narrays),as.integer(nprobes),as.integer(nprobetypes),as.integer(0),as.integer(0),as.integer(2),as.integer(trt.cov),as.integer(1))[[1]],ncol=10)
+   matrix(.C("R_PLM_matrix_probe_type_effect",as.double(as.vector(X)), as.integer(narrays),as.integer(nprobes),as.integer(nprobetypes),as.integer(0),as.integer(1),as.integer(2),as.integer(trt.cov),as.integer(1))[[1]],ncol=10)
+   matrix(.C("R_PLM_matrix_probe_type_effect",as.double(as.vector(X)), as.integer(narrays),as.integer(nprobes),as.integer(nprobetypes),as.integer(0),as.integer(-1),as.integer(2),as.integer(trt.cov),as.integer(1))[[1]],ncol=10)
+   
+   trt.cov <- rep(0:4,2)
+   matrix(.C("R_PLM_matrix_probe_type_effect",as.double(as.vector(X)), as.integer(narrays),as.integer(nprobes),as.integer(nprobetypes),as.integer(0),as.integer(-1),as.integer(2),as.integer(trt.cov),as.integer(4))[[1]],ncol=10)
+   
+   
+   
+   
+                                         #probe effects - overall
+   ncols <- 11
+   X <- matrix(0,narrays*nprobes*nprobetypes,ncols)
+   
+   
+   matrix(.C("R_PLM_matrix_probe_effect",as.double(as.vector(X)), as.integer(narrays),as.integer(nprobes),as.integer(nprobetypes),as.integer(0),as.integer(0),as.integer(0),as.integer(trt.cov),as.integer(4))[[1]],ncol=11)
+   matrix(.C("R_PLM_matrix_probe_effect",as.double(as.vector(X)), as.integer(narrays),as.integer(nprobes),as.integer(nprobetypes),as.integer(0),as.integer(1),as.integer(0),as.integer(trt.cov),as.integer(4))[[1]],ncol=11)
+   matrix(.C("R_PLM_matrix_probe_effect",as.double(as.vector(X)), as.integer(narrays),as.integer(nprobes),as.integer(nprobetypes),as.integer(0),as.integer(-1),as.integer(0),as.integer(trt.cov),as.integer(4))[[1]],ncol=11)
+   
+   
+   
+                                         #probe effects within treatment or genotype factor
+   trt.cov <- rep(0:1,5)
+   ncols <- 22
+   X <- matrix(0,narrays*nprobes*nprobetypes,ncols)
+   matrix(.C("R_PLM_matrix_probe_effect",as.double(as.vector(X)), as.integer(narrays),as.integer(nprobes),as.integer(nprobetypes),as.integer(0),as.integer(0),as.integer(2),as.integer(trt.cov),as.integer(1))[[1]],ncol=22)
+   matrix(.C("R_PLM_matrix_probe_effect",as.double(as.vector(X)), as.integer(narrays),as.integer(nprobes),as.integer(nprobetypes),as.integer(0),as.integer(1),as.integer(2),as.integer(trt.cov),as.integer(1))[[1]],ncol=22)
+   matrix(.C("R_PLM_matrix_probe_effect",as.double(as.vector(X)), as.integer(narrays),as.integer(nprobes),as.integer(nprobetypes),as.integer(0),as.integer(-1),as.integer(2),as.integer(trt.cov),as.integer(1))[[1]],ncol=22)
+   
+   
+                                         #probe effects within probetype
+   matrix(.C("R_PLM_matrix_probe_effect",as.double(as.vector(X)), as.integer(narrays),as.integer(nprobes),as.integer(nprobetypes),as.integer(0),as.integer(0),as.integer(3),as.integer(trt.cov),as.integer(1))[[1]],ncol=22)
+   matrix(.C("R_PLM_matrix_probe_effect",as.double(as.vector(X)), as.integer(narrays),as.integer(nprobes),as.integer(nprobetypes),as.integer(0),as.integer(1),as.integer(3),as.integer(trt.cov),as.integer(1))[[1]],ncol=22)
+   matrix(.C("R_PLM_matrix_probe_effect",as.double(as.vector(X)), as.integer(narrays),as.integer(nprobes),as.integer(nprobetypes),as.integer(0),as.integer(-1),as.integer(3),as.integer(trt.cov),as.integer(1))[[1]],ncol=22)
+   
+   
+                                         #probe effects within probetype within treatment or genotype factor variable
+   trt.cov <- rep(0:1,5)
+   ncols <- 44
+   X <- matrix(0,narrays*nprobes*nprobetypes,ncols)
+   matrix(.C("R_PLM_matrix_probe_effect",as.double(as.vector(X)), as.integer(narrays),as.integer(nprobes),as.integer(nprobetypes),as.integer(0),as.integer(0),as.integer(4),as.integer(trt.cov),as.integer(1))[[1]],ncol=44)
+   matrix(.C("R_PLM_matrix_probe_effect",as.double(as.vector(X)), as.integer(narrays),as.integer(nprobes),as.integer(nprobetypes),as.integer(0),as.integer(1),as.integer(4),as.integer(trt.cov),as.integer(1))[[1]],ncol=44)
+   matrix(.C("R_PLM_matrix_probe_effect",as.double(as.vector(X)), as.integer(narrays),as.integer(nprobes),as.integer(nprobetypes),as.integer(0),as.integer(-1),as.integer(4),as.integer(trt.cov),as.integer(1))[[1]],ncol=44)
+   
+   nprobetypes <- 1
+   trt.cov <- rep(0:1,5)
+   ncols <- 44
+   X <- matrix(0,narrays*nprobes*nprobetypes,ncols)
+   matrix(.C("R_PLM_matrix_probe_effect",as.double(as.vector(X)), as.integer(narrays),as.integer(nprobes),as.integer(nprobetypes),as.integer(0),as.integer(0),as.integer(4),as.integer(trt.cov),as.integer(1))[[1]],ncol=44)
+   matrix(.C("R_PLM_matrix_probe_effect",as.double(as.vector(X)), as.integer(narrays),as.integer(nprobes),as.integer(nprobetypes),as.integer(0),as.integer(1),as.integer(4),as.integer(trt.cov),as.integer(1))[[1]],ncol=44)
+   matrix(.C("R_PLM_matrix_probe_effect",as.double(as.vector(X)), as.integer(narrays),as.integer(nprobes),as.integer(nprobetypes),as.integer(0),as.integer(-1),as.integer(4),as.integer(trt.cov),as.integer(1))[[1]],ncol=44)
+   
+   
+                                         # copy across chip level variables into model matrix
+   nprobetypes <- 1
+   trt.cov <- rep(0:1,5)
+   ncols <- 10
+   X <- matrix(0,narrays*nprobes*nprobetypes,ncols)
+   trt.variables <- rnorm(10)
+   
+   matrix(.C("R_PLM_matrix_chiplevel",as.double(as.vector(X)), as.integer(narrays),as.integer(nprobes),as.integer(nprobetypes),as.integer(0),as.double(trt.variables),as.integer(1))[[1]],ncol=10)
+ 
+ 
+ ###
+ ### Build a few design matrices and compare with R model.matrix
+ ###
+ 
+ 
+   for (nprobetypes in 1:2){
+     for (narrays in 2:15){
+       for (nprobes in 2:20){
+         for (constraint.type in c("contr.sum","contr.treatment")){
+           if (constraint.type == "contr.sum"){
+             ct.type <- -1
+           } else {
+             ct.type <- 1
+           }
+ 
+           
+           ncols <- nprobes -1 + narrays
+           X <- matrix(0,narrays*nprobes*nprobetypes,ncols)
+           
+           X <- matrix(.C("R_PLM_Matrix_constructtest",as.double(as.vector(X)), as.integer(narrays),as.integer(nprobes),as.integer(nprobetypes),as.integer(1),as.integer(1),as.integer(0),as.integer(1),as.integer(ct.type))[[1]],ncol=ncols)
+           
+           probe.effect <- factor(rep(1:nprobes,narrays*nprobetypes))
+           sample.effect <- factor(rep(rep(c(1:narrays),rep(nprobes,narrays)),nprobetypes))
+           if (nprobetypes == 2){
+             probe.type.effect <- factor(rep(1:2,c(narrays*nprobes,narrays*nprobes)))
+           } else {
+             probe.type.effect <- factor(rep(1,narrays*nprobes))
+           }
+           
+           if (any(X!=model.matrix(~ C(sample.effect,constraint.type) + C(probe.effect,constraint.type)))){
+             stop("Model matrix function problem ",narrays," ", nprobes, " ", nprobetypes)
+           }
+           
+           X <- matrix(0,narrays*nprobes*nprobetypes,ncols)
+           X <- matrix(.C("R_PLM_Matrix_constructtest",as.double(as.vector(X)), as.integer(narrays),as.integer(nprobes),as.integer(nprobetypes),as.integer(0),as.integer(1),as.integer(0),as.integer(1),as.integer(ct.type))[[1]],ncol=ncols)
+           
+           if (any(X!=model.matrix(~ -1 + C(sample.effect,constraint.type) + C(probe.effect,constraint.type)))){
+             stop("Model matrix function problem ",narrays," ", nprobes," ", nprobetypes)
+           }
+           
+           ncols <- nprobes
+           X <- matrix(0,narrays*nprobes*nprobetypes,ncols)
+           X <- matrix(.C("R_PLM_Matrix_constructtest",as.double(as.vector(X)), as.integer(narrays),as.integer(nprobes),as.integer(nprobetypes),as.integer(1),as.integer(0),as.integer(0),as.integer(1),as.integer(ct.type))[[1]],ncol=ncols)
+           
+           if (any(X!=model.matrix(~  C(probe.effect,constraint.type)))){
+             stop("Model matrix function problem ",narrays," ", nprobes," ", nprobetypes)
+           }
+           
+           
+           ncols <- nprobes
+           X <- matrix(0,narrays*nprobes*nprobetypes,ncols)
+           X <- matrix(.C("R_PLM_Matrix_constructtest",as.double(as.vector(X)), as.integer(narrays),as.integer(nprobes),as.integer(nprobetypes),as.integer(0),as.integer(0),as.integer(0),as.integer(1),as.integer(ct.type))[[1]],ncol=ncols)
+           
+           if (any(X!=model.matrix(~-1+  C(probe.effect,constraint.type)))){
+             stop("Model matrix function problem ",narrays," ", nprobes," ", nprobetypes)
+           }
+           
+         }
+       }
+     }
+   }
+   
+ ###
+ ### Build a few more design matrices and compare with R model.matrix
+ ###
+ 
+   
+   for (narrays in 2:15){
+     for (nprobes in 2:20){
+       for (constraint.type in c("contr.sum","contr.treatment")){
+         probe.effect <- factor(rep(1:nprobes,narrays*nprobetypes))
+         sample.effect <- factor(rep(rep(c(1:narrays),rep(nprobes,narrays)),nprobetypes))
+         if (constraint.type == "contr.sum"){
+           ct.type <- -1
+         } else {
+           ct.type <- 1
+         }
+ 
+        
+         if (nprobetypes == 2){
+           probe.type.effect <- factor(rep(1:2,c(narrays*nprobes,narrays*nprobes)))
+         } else {
+           probe.type.effect <- factor(rep(1,narrays*nprobes))
+         }
+         ncols <- nprobetypes + nprobes -1
+         X <- matrix(0,narrays*nprobes*nprobetypes,ncols)
+         X <- matrix(.C("R_PLM_Matrix_constructtest",as.double(as.vector(X)), as.integer(narrays),as.integer(nprobes),as.integer(nprobetypes),as.integer(0),as.integer(0),as.integer(1),as.integer(1),as.integer(ct.type))[[1]],ncol=ncols)
+         
+         if (any(X!=model.matrix(~-1+ C(probe.type.effect,constraint.type) +  C(probe.effect,constraint.type)))){
+           stop("Model matrix function problem ",narrays," ", nprobes," ", nprobetypes)
+         }
+         
+         ncols <- nprobetypes + nprobes -1
+         X <- matrix(0,narrays*nprobes*nprobetypes,ncols)
+         X <- matrix(.C("R_PLM_Matrix_constructtest",as.double(as.vector(X)), as.integer(narrays),as.integer(nprobes),as.integer(nprobetypes),as.integer(1),as.integer(0),as.integer(1),as.integer(1),as.integer(ct.type))[[1]],ncol=ncols)
+         
+         if (any(X!=model.matrix(~ C(probe.type.effect,constraint.type) +  C(probe.effect,constraint.type)))){
+           stop("Model matrix function problem ",narrays," ", nprobes," ", nprobetypes)
+         }
+         
+         ncols <- narrays + nprobetypes + nprobes -2
+         X <- matrix(0,narrays*nprobes*nprobetypes,ncols)
+         X <- matrix(.C("R_PLM_Matrix_constructtest",as.double(as.vector(X)), as.integer(narrays),as.integer(nprobes),as.integer(nprobetypes),as.integer(0),as.integer(1),as.integer(1),as.integer(1),as.integer(ct.type))[[1]],ncol=ncols)
+         
+         if (any(X!=model.matrix(~ -1 + C(sample.effect,constraint.type) + C(probe.type.effect,constraint.type) +  C(probe.effect,constraint.type)))){
+           stop("Model matrix function problem ",narrays," ", nprobes," ", nprobetypes)
+         }
+         
+         ncols <- narrays + nprobetypes + nprobes -2
+         X <- matrix(0,narrays*nprobes*nprobetypes,ncols)
+         X <- matrix(.C("R_PLM_Matrix_constructtest",as.double(as.vector(X)), as.integer(narrays),as.integer(nprobes),as.integer(nprobetypes),as.integer(1),as.integer(1),as.integer(1),as.integer(1),as.integer(ct.type))[[1]],ncol=ncols)
+         
+         if (any(X!=model.matrix(~ + C(sample.effect,constraint.type) + C(probe.type.effect,constraint.type) +  C(probe.effect,constraint.type)))){
+           stop("Model matrix function problem ",narrays," ", nprobes," ", nprobetypes)
+         }
+         
+         ncols <- narrays + nprobetypes -1
+         X <- matrix(0,narrays*nprobes*nprobetypes,ncols)
+         X <- matrix(.C("R_PLM_Matrix_constructtest",as.double(as.vector(X)), as.integer(narrays),as.integer(nprobes),as.integer(nprobetypes),as.integer(1),as.integer(1),as.integer(1),as.integer(0),as.integer(ct.type))[[1]],ncol=ncols)
+         
+         if (any(X!=model.matrix(~ C(sample.effect,constraint.type) + C(probe.type.effect,constraint.type)))){
+           stop("Model matrix function problem ",narrays," ", nprobes," ", nprobetypes)
+         }    
+         
+         ncols <- narrays + nprobetypes -1
+         X <- matrix(0,narrays*nprobes*nprobetypes,ncols)
+         X <- matrix(.C("R_PLM_Matrix_constructtest",as.double(as.vector(X)), as.integer(narrays),as.integer(nprobes),as.integer(nprobetypes),as.integer(0),as.integer(1),as.integer(1),as.integer(0),as.integer(ct.type))[[1]],ncol=ncols)
+         
+         if (any(X!=model.matrix(~ -1 + C(sample.effect,constraint.type) + C(probe.type.effect,constraint.type)))){
+           stop("Model matrix function problem ",narrays," ", nprobes," ", nprobetypes)
+         }    
+         
+         ncols <- nprobetypes
+         X <- matrix(0,narrays*nprobes*nprobetypes,ncols)
+         X <- matrix(.C("R_PLM_Matrix_constructtest",as.double(as.vector(X)), as.integer(narrays),as.integer(nprobes),as.integer(nprobetypes),as.integer(1),as.integer(0),as.integer(1),as.integer(0),as.integer(ct.type))[[1]],ncol=ncols)
+         
+         if (any(X!=model.matrix(~ C(probe.type.effect,constraint.type)))){
+           stop("Model matrix function problem ",narrays," ", nprobes," ", nprobetypes)
+         }    
+       
+         ncols <- nprobetypes
+         X <- matrix(0,narrays*nprobes*nprobetypes,ncols)
+         X <- matrix(.C("R_PLM_Matrix_constructtest",as.double(as.vector(X)), as.integer(narrays),as.integer(nprobes),as.integer(nprobetypes),as.integer(0),as.integer(0),as.integer(1),as.integer(0),as.integer(ct.type))[[1]],ncol=ncols)
+         
+         if (any(X!=model.matrix(~-1 +  C(probe.type.effect,constraint.type)))){
+           stop("Model matrix function problem ",narrays," ", nprobes," ", nprobetypes)
+         }    
+         
+       }
+       
+       
+     }
+   }
+ 
+ 
+   narrays <- 2
+   nprobes <- 7
+   nprobetypes <- 2
+   
+   probe.effect <- factor(rep(1:nprobes,narrays*nprobetypes))
+   sample.effect <- factor(rep(rep(c(1:narrays),rep(nprobes,narrays)),nprobetypes))
+   if (constraint.type == "contr.sum"){
+     ct.type <- -1
+   } else {
+     ct.type <- 1
+   }
+   
+   
+   if (nprobetypes == 2){
+     probe.type.effect <- factor(rep(1:2,c(narrays*nprobes,narrays*nprobes)))
+   } else {
+     probe.type.effect <- factor(rep(1,narrays*nprobes))
+   }
+   
+ 
+   model.matrix(~-1 +probe.effect/probe.type.effect)
+ 
+ 
+   library(affyPLM)
+   output <- verify.output.param(list(weights = FALSE, residuals = FALSE, varcov = "none", resid.SE = TRUE))
+   modelparam <- list(trans.fn="log2", se.type = 4, psi.type = 0, psi.k =1.345,max.its = 20, init.method = "ls",weights.chip=NULL,weights.probe=NULL)
+ 
+   library(affydata)
+   data(Dilution)
+ 
+   # fit a PM ~ samples model
+   R.model <- list(mmorpm.covariate=0,response.variable=1,which.parameter.types=as.integer(c(0,0,1,0,0)),strata=as.integer(c(0,0,0,0,0)),constraints=as.integer(c(0,0,0,0,0)),probe.type.trt.factor=NULL,max.probe.type.trt.factor=0,probe.trt.factor=NULL,max.probe.trt.factor=0,chipcovariates =matrix(0,0,0), probe.type.levels=list(),probe.trt.levels=list())
+   Fitresults <- .Call("rlm_PLMset",pm(Dilution),mm(Dilution),probeNames(Dilution),length(geneNames(Dilution)),R.model,output,modelparam)
+ 
+ 
+   sample.effect <- rep(1:4,c(16,16,16,16))
+   probe.effect <- rep(1:16,4)
+ 
+   library(MASS)
+   fit <- rlm(as.vector(log2(pm(Dilution)[1:16,])) ~ -1 + factor(sample.effect))
+   
+   if (any(Fitresults[[1]][1,] != coef(fit))){
+     stop("Problem in model fitting procedure")
+   }
+ 
+   sample.effect <- rep(1:4,c(20,20,20,20))
+   probe.effect <- rep(1:20,4)
+   fit <- rlm(as.vector(log2(pm(Dilution)[201781:201800,])) ~ -1 + factor(sample.effect))
+    if (any(Fitresults[[1]][12625,] != coef(fit))){
+     stop("Problem in model fitting procedure")
+   }
+ 
+ 
+   # fit a samples + probes model
+   R.model <- list(mmorpm.covariate=0,response.variable=1,which.parameter.types=as.integer(c(0,0,1,0,1)),strata=as.integer(c(0,0,0,0,0)),constraints=as.integer(c(0,0,0,0,-1)),probe.type.trt.factor=NULL,max.probe.type.trt.factor=0,probe.trt.factor=NULL,max.probe.trt.factor=0,chipcovariates =matrix(0,0,0), probe.type.levels=list(),probe.trt.levels=list())
+ 
+   Fitresults <- .Call("rlm_PLMset",pm(Dilution),mm(Dilution),probeNames(Dilution),length(geneNames(Dilution)),R.model,output,modelparam)
+   sample.effect <- rep(1:4,c(16,16,16,16))
+   probe.effect <- rep(1:16,4)
+ 
+   fit <- rlm(as.vector(log2(pm(Dilution)[1:16,])) ~ -1 + factor(sample.effect)+C(factor(probe.effect),"contr.sum"))
+   
+   if (any(abs(Fitresults[[1]][1,] -coef(fit)[1:4]) > 1e-13)){
+     stop("Problem in model fitting procedure")
+   }
+ 
+    if (any(abs(as.vector(Fitresults[[2]][[1]]) - coef(fit)[5:19]) > 1e-13)){
+     stop("Problem in model fitting procedure")
+   }
+ 
+ 
+ 
+   
+   sample.effect <- rep(1:4,c(20,20,20,20))
+   probe.effect <- rep(1:20,4)
+   fit <- rlm(as.vector(log2(pm(Dilution)[201781:201800,])) ~ -1 + factor(sample.effect)+C(factor(probe.effect),"contr.sum"))
+   
+   if (any(abs(Fitresults[[1]][12625,]  -coef(fit)[1:4])> 1e-13)){
+     stop("Problem in model fitting procedure")
+   }
+ 
+   if (any(abs(as.vector(Fitresults[[2]][[12625]])- coef(fit)[5:23])>1e-13)){
+     stop("Problem in model fitting procedure")
+   }
+ 
+   # fit an MM ~ samples model
+   R.model <- list(mmorpm.covariate=0,response.variable=-1,which.parameter.types=as.integer(c(0,0,1,0,0)),strata=as.integer(c(0,0,0,0,0)),constraints=as.integer(c(0,0,0,0,0)),probe.type.trt.factor=NULL,max.probe.type.trt.factor=0,probe.trt.factor=NULL,max.probe.trt.factor=0,chipcovariates =matrix(0,0,0), probe.type.levels=list(),probe.trt.levels=list())
+   Fitresults <- .Call("rlm_PLMset",pm(Dilution),mm(Dilution),probeNames(Dilution),length(geneNames(Dilution)),R.model,output,modelparam)
+ 
+ 
+   sample.effect <- rep(1:4,c(16,16,16,16))
+   probe.effect <- rep(1:16,4)
+ 
+   library(MASS)
+   fit <- rlm(as.vector(log2(mm(Dilution)[1:16,])) ~ -1 + factor(sample.effect))
+   
+   if (any(abs(Fitresults[[1]][1,] - coef(fit)) > 1e-13)){
+     stop("Problem in model fitting procedure")
+   }
+ 
+   sample.effect <- rep(1:4,c(20,20,20,20))
+   probe.effect <- rep(1:20,4)
+   fit <- rlm(as.vector(log2(mm(Dilution)[201781:201800,])) ~ -1 + factor(sample.effect))
+    if (any(abs(Fitresults[[1]][12625,] - coef(fit))>1e-13)){
+     stop("Problem in model fitting procedure")
+   }
+ 
+   # fit a MM ~ samples + probes model
+   R.model <- list(mmorpm.covariate=0,response.variable=-1,which.parameter.types=as.integer(c(0,0,1,0,1)),strata=as.integer(c(0,0,0,0,0)),constraints=as.integer(c(0,0,0,0,-1)),probe.type.trt.factor=NULL,max.probe.type.trt.factor=0,probe.trt.factor=NULL,max.probe.trt.factor=0,chipcovariates =matrix(0,0,0), probe.type.levels=list(),probe.trt.levels=list())
+ 
+   Fitresults <- .Call("rlm_PLMset",pm(Dilution),mm(Dilution),probeNames(Dilution),length(geneNames(Dilution)),R.model,output,modelparam)
+   sample.effect <- rep(1:4,c(16,16,16,16))
+   probe.effect <- rep(1:16,4)
+ 
+   fit <- rlm(as.vector(log2(mm(Dilution)[1:16,])) ~ -1 + factor(sample.effect)+C(factor(probe.effect),"contr.sum"))
+   
+   if (any(abs(Fitresults[[1]][1,]-coef(fit)[1:4]) > 1e-13)){
+     stop("Problem in model fitting procedure")
+   }
+ 
+    if (any(abs(as.vector(Fitresults[[2]][[1]])- coef(fit)[5:19])>1e-13)){
+     stop("Problem in model fitting procedure")
+   }
+ 
+ 
+ 
+   
+   sample.effect <- rep(1:4,c(20,20,20,20))
+   probe.effect <- rep(1:20,4)
+   fit <- rlm(as.vector(log2(mm(Dilution)[201781:201800,])) ~ -1 + factor(sample.effect)+C(factor(probe.effect),"contr.sum"))
+   
+   if (any(abs(Fitresults[[1]][12625,]- coef(fit)[1:4])>1e-13)){
+     stop("Problem in model fitting procedure")
+   }
+ 
+   if (any(abs(as.vector(Fitresults[[2]][[12625]])-coef(fit)[5:23])>1e14)){
+     stop("Problem in model fitting procedure")
+   }
+ 
+ 
+   # a treatment model
+   treatment.effect <- c(1,1,2,2)
+ 
+   covariates <- model.matrix(~ -1 + as.factor(treatment.effect))
+ 
+     R.model <- list(mmorpm.covariate=0,response.variable=-1,which.parameter.types=as.integer(c(0,1,0,0,0)),strata=as.integer(c(0,0,0,0,0)),constraints=as.integer(c(0,0,0,0,0)),probe.type.trt.factor=NULL,max.probe.type.trt.factor=0,probe.trt.factor=NULL,max.probe.trt.factor=0,chipcovariates =covariates, probe.type.levels=list(),probe.trt.levels=list())
+   
+ Fitresults <- .Call("rlm_PLMset",pm(Dilution),mm(Dilution),probeNames(Dilution),length(geneNames(Dilution)),R.model,output,modelparam)
+   
+   treatment.effect <- rep(c(1,1,2,2),c(16,16,16,16))
+   fit <- rlm(as.vector(log2(mm(Dilution)[1:16,])) ~ -1 + factor(treatment.effect))
+   
+   if (any(abs(Fitresults[[1]][1,]-coef(fit)[1:2]) > 1e-13)){
+     stop("Problem in model fitting procedure")
+   }
+ 
+    output <-  verify.output.param(list(weights = FALSE, residuals = FALSE, varcov = "none", resid.SE = TRUE))
+   modelparam <- list(trans.fn="log2", se.type = 4, psi.type = 0, psi.k =1.345,max.its = 20, init.method = "ls",weights.chip=NULL,weights.probe=NULL)
+ 
+ 
+   # a treatment + probes model with contr.treatment constraint
+   R.model <- list(mmorpm.covariate=0,response.variable=-1,which.parameter.types=as.integer(c(0,1,0,0,1)),strata=as.integer(c(0,0,0,0,0)),constraints=as.integer(c(0,0,0,0,1)),probe.type.trt.factor=NULL,max.probe.type.trt.factor=0,probe.trt.factor=NULL,max.probe.trt.factor=0,chipcovariates =covariates, probe.type.levels=list(),probe.trt.levels=list())
+   
+   Fitresults <- .Call("rlm_PLMset",pm(Dilution),mm(Dilution),probeNames(Dilution),length(geneNames(Dilution)),R.model,output,modelparam)
+   
+   
+   treatment.effect <- rep(c(1,1,2,2),c(20,20,20,20))
+   probe.effect <- rep(1:20,4)
+   fit <- rlm(as.vector(log2(mm(Dilution)[201761:201780,])) ~ -1 + factor(treatment.effect)+C(factor(probe.effect),"contr.treatment"))
+   
+   if (any(abs(Fitresults[[1]][12624,]-coef(fit)[1:2]) > 1e-13)){
+     stop("Problem in model fitting procedure")
+   }
+ 
+   if (any(abs(as.vector(Fitresults[[2]][[12624]])-coef(fit)[3:21])>1e14)){
+     stop("Problem in model fitting procedure")
+   }
+ 
+ 
+   
+   
+   # MM + samples + probes
+   R.model <- list(mmorpm.covariate=1,response.variable=1,which.parameter.types=as.integer(c(0,0,0,0,0)),strata=as.integer(c(0,0,0,0,0)),constraints=as.integer(c(0,0,0,0,0)),probe.type.trt.factor=NULL,max.probe.type.trt.factor=0,probe.trt.factor=NULL,max.probe.trt.factor=0,chipcovariates =matrix(0,0,0), probe.type.levels=list(),probe.trt.levels=list())
+ 
+ 
+   Fitresults <- .Call("rlm_PLMset",pm(Dilution),mm(Dilution),probeNames(Dilution),length(geneNames(Dilution)),R.model,output,modelparam)
+   
+   
+  sample.effect <- rep(1:4,c(16,16,16,16))
+   probe.effect <- rep(1:16,4)
+ 
+   fit <- rlm(as.vector(log2(pm(Dilution)[1:16,])) ~ -1 + as.vector(log2(mm(Dilution)[1:16,])))
+   
+ 
+   if (any(abs(as.vector(Fitresults[[6]][[1]]) - coef(fit)) > 1e-13)){
+     stop("Problem in model fitting procedure")
+   }
+ 
+   R.model <- list(mmorpm.covariate=1,response.variable=1,which.parameter.types=as.integer(c(0,0,1,0,0)),strata=as.integer(c(0,0,0,0,0)),constraints=as.integer(c(0,0,0,0,0)),probe.type.trt.factor=NULL,max.probe.type.trt.factor=0,probe.trt.factor=NULL,max.probe.trt.factor=0,chipcovariates =matrix(0,0,0),probe.type.levels=list(),probe.trt.levels=list())
+ 
+ 
+   Fitresults <- .Call("rlm_PLMset",pm(Dilution),mm(Dilution),probeNames(Dilution),length(geneNames(Dilution)),R.model,output,modelparam)
+   
+   fit <- rlm(as.vector(log2(pm(Dilution)[1:16,])) ~ -1 + as.vector(log2(mm(Dilution)[1:16,]))+ as.factor(sample.effect))
+   if (any(abs(as.vector(Fitresults[[6]][[1]]) - coef(fit)[1]) > 1e-13)){
+     stop("Problem in model fitting procedure")
+   }
+ 
+  if (any(abs(as.vector(Fitresults[[1]][1,]) - coef(fit)[2:5]) > 1e-13)){
+     stop("Problem in model fitting procedure")
+   }
+ 
+   R.model <- list(mmorpm.covariate=1,response.variable=1,which.parameter.types=as.integer(c(0,0,1,0,1)),strata=as.integer(c(0,0,0,0,0)),constraints=as.integer(c(0,0,0,0,-1)),probe.type.trt.factor=NULL,max.probe.type.trt.factor=0,probe.trt.factor=NULL,max.probe.trt.factor=0,chipcovariates =matrix(0,0,0),probe.type.levels=list(),probe.trt.levels=list())
+ 
+ 
+   Fitresults <- .Call("rlm_PLMset",pm(Dilution),mm(Dilution),probeNames(Dilution),length(geneNames(Dilution)),R.model,output,modelparam)
+   
+   fit <- rlm(as.vector(log2(pm(Dilution)[1:16,])) ~ -1 + as.vector(log2(mm(Dilution)[1:16,]))+ as.factor(sample.effect) + C(as.factor(probe.effect),"contr.sum"))
+   if (any(abs(as.vector(Fitresults[[6]][[1]]) - coef(fit)[1]) > 1e-13)){
+     stop("Problem in model fitting procedure")
+   }
+ 
+   if (any(abs(as.vector(Fitresults[[1]][1,]) - coef(fit)[2:5]) > 1e-13)){
+     stop("Problem in model fitting procedure")
+   }
+ 
+ 
+   ## PM and MM are response
+ 
+   
+   sample.effect <- rep(1:4,c(32,32,32,32))
+   probe.effect <- rep(1:16,8)
+   
+ 
+   
+   # PMMM ~ -1 + samples
+   R.model <- list(mmorpm.covariate=0,response.variable=0,which.parameter.types=as.integer(c(0,0,1,0,0)),strata=as.integer(c(0,0,0,0,0)),constraints=as.integer(c(0,0,0,0,0)),probe.type.trt.factor=NULL,max.probe.type.trt.factor=0,probe.trt.factor=NULL,max.probe.trt.factor=0,chipcovariates =matrix(0,0,0),probe.type.levels=list(),probe.trt.levels=list())
+   Fitresults <- .Call("rlm_PLMset",pm(Dilution),mm(Dilution),probeNames(Dilution),length(geneNames(Dilution)),R.model,output,modelparam)
+   
+   
+   fit <- rlm(as.vector(rbind(log2(pm(Dilution)[1:16,]),log2(mm(Dilution)[1:16,]))) ~ -1 + as.factor(sample.effect))
+   if (any(abs(as.vector(Fitresults[[1]][1,]) - coef(fit)) > 1e-13)){
+     stop("Problem in model fitting procedure")
+   }
+ 
+   # PMMM ~ -1 + samples +PROBES
+   R.model <- list(mmorpm.covariate=0,response.variable=0,which.parameter.types=as.integer(c(0,0,1,0,1)),strata=as.integer(c(0,0,0,0,0)),constraints=as.integer(c(0,0,0,0,-1)),probe.type.trt.factor=NULL,max.probe.type.trt.factor=0,probe.trt.factor=NULL,max.probe.trt.factor=0,chipcovariates =matrix(0,0,0),probe.type.levels=list(),probe.trt.levels=list())
+   Fitresults <- .Call("rlm_PLMset",pm(Dilution),mm(Dilution),probeNames(Dilution),length(geneNames(Dilution)),R.model,output,modelparam)
+   
+   fit <- rlm(as.vector(rbind(log2(pm(Dilution)[1:16,]),log2(mm(Dilution)[1:16,]))) ~ -1 + as.factor(sample.effect)+C(as.factor(probe.effect),"contr.sum") )
+   if (any(abs(as.vector(Fitresults[[1]][1,]) - coef(fit)[1:4]) > 1e-13)){
+     stop("Problem in model fitting procedure")
+   }
+ 
+   # a probe.type effect
+   probe.type.effect <- rep(rep(1:2,c(16,16)),4)
+ 
+   # PMMM ~ -1 + samples + probe.type + PROBES
+   R.model <- list(mmorpm.covariate=0,response.variable=0,which.parameter.types=as.integer(c(0,0,1,1,1)),strata=as.integer(c(0,0,0,0,0)),constraints=as.integer(c(0,0,0,-1,-1)),probe.type.trt.factor=NULL,max.probe.type.trt.factor=0,probe.trt.factor=NULL,max.probe.trt.factor=0,chipcovariates =matrix(0,0,0),probe.type.levels=list(),probe.trt.levels=list())
+   Fitresults <- .Call("rlm_PLMset",pm(Dilution),mm(Dilution),probeNames(Dilution),length(geneNames(Dilution)),R.model,output,modelparam)
+   
+   fit <- rlm(as.vector(rbind(log2(pm(Dilution)[1:16,]),log2(mm(Dilution)[1:16,]))) ~ -1 + as.factor(sample.effect)+ C(as.factor(probe.type.effect),"contr.sum")+ C(as.factor(probe.effect),"contr.sum") )
+   
+    if (any(abs(as.vector(Fitresults[[1]][1,]) - coef(fit)[1:4]) > 1e-13)){
+     stop("Problem in model fitting procedure")
+   }
+ 
+    if (any(abs(as.vector(Fitresults[[6]][1,]) - coef(fit)[5]) > 1e-13)){
+     stop("Problem in model fitting procedure")
+   }
+ 
+ 
+ 
+   #### store weights PM ~ -1 + samples
+ 
+   output <-  verify.output.param(list(weights = TRUE, residuals = TRUE, varcov = "none", resid.SE = TRUE))
+   modelparam <- list(trans.fn="log2", se.type = 4, psi.type = 0, psi.k =1.345,max.its = 20, init.method = "ls",weights.chip=NULL,weights.probe=NULL)
+ 
+   
+   R.model <- list(mmorpm.covariate=0,response.variable=1,which.parameter.types=as.integer(c(0,0,1,0,0)),strata=as.integer(c(0,0,0,0,0)),constraints=as.integer(c(0,0,0,0,0)),probe.type.trt.factor=NULL,max.probe.type.trt.factor=0,probe.trt.factor=NULL,max.probe.trt.factor=0,chipcovariates =matrix(0,0,0),probe.type.levels=list(),probe.trt.levels=list())
+   Fitresults <- .Call("rlm_PLMset",pm(Dilution),mm(Dilution),probeNames(Dilution),length(geneNames(Dilution)),R.model,output,modelparam)
+  
+ 
+ #### store weights PMMM ~ -1 + samples
+ 
+   output <-  verify.output.param(list(weights = TRUE, residuals = TRUE, varcov = "none", resid.SE = TRUE))
+   modelparam <- list(trans.fn="log2", se.type = 4, psi.type = 0, psi.k =1.345,max.its = 20, init.method = "ls",weights.chip=NULL,weights.probe=NULL)
+ 
+   
+   R.model <- list(mmorpm.covariate=0,response.variable=0,which.parameter.types=as.integer(c(0,0,1,0,0)),strata=as.integer(c(0,0,0,0,0)),constraints=as.integer(c(0,0,0,0,0)),probe.type.trt.factor=NULL,max.probe.type.trt.factor=0,probe.trt.factor=NULL,max.probe.trt.factor=0,chipcovariates =matrix(0,0,0),probe.type.levels=list(),probe.trt.levels=list())
+   Fitresults <- .Call("rlm_PLMset",pm(Dilution),mm(Dilution),probeNames(Dilution),length(geneNames(Dilution)),R.model,output,modelparam)
+   
+ #### store weights PMMM ~ -1 + samples + probe.type + probes
+ 
+   output <- verify.output.param(list(weights = TRUE, residuals = TRUE, varcov ="none", resid.SE = TRUE))
+   modelparam <- list(trans.fn="log2", se.type = 4, psi.type = 0, psi.k =1.345,max.its = 20, init.method = "ls",weights.chip=NULL,weights.probe=NULL)
+ 
+   
+   R.model <- list(mmorpm.covariate=0,response.variable=0,which.parameter.types=as.integer(c(0,0,1,1,1)),strata=as.integer(c(0,0,0,0,0)),constraints=as.integer(c(0,0,0,1,-1)),probe.type.trt.factor=NULL,max.probe.type.trt.factor=0,probe.trt.factor=NULL,max.probe.trt.factor=0,chipcovariates =matrix(0,0,0),probe.type.levels=list(),probe.trt.levels=list())
+   Fitresults <- .Call("rlm_PLMset",pm(Dilution),mm(Dilution),probeNames(Dilution),length(geneNames(Dilution)),R.model,output,modelparam)
+   
+   ## PM ~ -1 + treatment + probes in treatment
+   output <- verify.output.param(list(weights = TRUE, residuals = TRUE, varcov = "none", resid.SE = TRUE))
+   modelparam <- list(trans.fn="log2", se.type = 4, psi.type = 0, psi.k =1.345,max.its = 20, init.method = "ls",weights.chip=NULL,weights.probe=NULL)
+ 
+   treatment.effect <- c(1,1,2,2)
+ 
+   covariates <- model.matrix(~ -1 + as.factor(treatment.effect))
+ 
+   R.model <- list(mmorpm.covariate=0,response.variable=1,which.parameter.types=as.integer(c(0,1,0,0,1)),strata=as.integer(c(0,0,0,0,2)),constraints=as.integer(c(0,0,0,0,-1)),probe.type.trt.factor=NULL,max.probe.type.trt.factor=0,probe.trt.factor=as.integer(c(0,0,1,1)),max.probe.trt.factor=1,chipcovariates =covariates,probe.type.levels=list(),probe.trt.levels=list("blah"=c("A","B")))
+ 
+   Fitresults <- .Call("rlm_PLMset",pm(Dilution),mm(Dilution),probeNames(Dilution),length(geneNames(Dilution)),R.model,output,modelparam)
+ 
+   ## PMMM ~ -1 + treatment + probes in treatment
+   output <- list(weights = TRUE, residuals = TRUE, varcov = c("none","chiplevel", "all"), resid.SE = TRUE)
+   modelparam <- list(trans.fn="log2", se.type = 4, psi.type = 0, psi.k =1.345,max.its = 20, init.method = "ls",weights.chip=NULL,weights.probe=NULL)
+ 
+   treatment.effect <- c(1,1,2,2)
+ 
+   covariates <- model.matrix(~ -1 + as.factor(treatment.effect))
+ 
+   R.model <- list(mmorpm.covariate=0,response.variable=0,which.parameter.types=as.integer(c(0,1,0,0,1)),strata=as.integer(c(0,0,0,0,2)),constraints=as.integer(c(0,0,0,0,-1)),probe.type.trt.factor=NULL,max.probe.type.trt.factor=0,probe.trt.factor=as.integer(c(0,0,1,1)),max.probe.trt.factor=1,chipcovariates =covariates,probe.type.levels=list(),probe.trt.levels=list("blah"=c("A","B")))
+ 
+   Fitresults <- .Call("rlm_PLMset",pm(Dilution),mm(Dilution),probeNames(Dilution),length(geneNames(Dilution)),R.model,output,modelparam)
+   
+    ## PMMM ~ -1 + treatment + probe.effect in treatment
+   output <- list(weights = TRUE, residuals = TRUE, varcov = c("none","chiplevel", "all"), resid.SE = TRUE)
+   modelparam <- list(trans.fn="log2", se.type = 4, psi.type = 0, psi.k =1.345,max.its = 20, init.method = "ls",weights.chip=NULL,weights.probe=NULL)
+ 
+   treatment.effect <- c(1,1,2,2)
+ 
+   covariates <- model.matrix(~ -1 + as.factor(treatment.effect))
+ 
+   R.model <- list(mmorpm.covariate=0,response.variable=0,which.parameter.types=as.integer(c(0,1,0,1,0)),strata=as.integer(c(0,0,0,2,0)),constraints=as.integer(c(0,0,0,-1,0)),probe.type.trt.factor=as.integer(c(0,0,1,1)),max.probe.type.trt.factor=1,probe.trt.factor=as.integer(c(0,0,1,1)),max.probe.trt.factor=0,chipcovariates =covariates,probe.type.levels=list("blah"=c("A","B")),probe.trt.levels=list("blah"=c("A","B")))
+ 
+   Fitresults <- .Call("rlm_PLMset",pm(Dilution),mm(Dilution),probeNames(Dilution),length(geneNames(Dilution)),R.model,output,modelparam)
+   
+    ## PMMM ~ -1+ probes
+   output <- list(weights = TRUE, residuals = TRUE, varcov = c("none","chiplevel", "all"), resid.SE = TRUE)
+   modelparam <- list(trans.fn="log2", se.type = 4, psi.type = 0, psi.k =1.345,max.its = 20, init.method = "ls",weights.chip=NULL,weights.probe=NULL)
+ 
+   R.model <- list(mmorpm.covariate=0,response.variable=0,which.parameter.types=as.integer(c(0,0,0,0,1)),strata=as.integer(c(0,0,0,0,0)),constraints=as.integer(c(0,0,0,0,0)),probe.type.trt.factor=NULL,max.probe.type.trt.factor=0,probe.trt.factor=NULL,max.probe.trt.factor=0,chipcovariates =matrix(0,0,0),probe.type.levels=list(),probe.trt.levels=list())
+ 
+   Fitresults <- .Call("rlm_PLMset",pm(Dilution),mm(Dilution),probeNames(Dilution),length(geneNames(Dilution)),R.model,output,modelparam)
+   
+    ## PMMM ~ -1+ probes.type
+   output <- list(weights = TRUE, residuals = TRUE, varcov = c("none","chiplevel", "all"), resid.SE = TRUE)
+   modelparam <- list(trans.fn="log2", se.type = 4, psi.type = 0, psi.k =1.345,max.its = 20, init.method = "ls",weights.chip=NULL,weights.probe=NULL)
+ 
+   R.model <- list(mmorpm.covariate=0,response.variable=0,which.parameter.types=as.integer(c(0,0,0,1,0)),strata=as.integer(c(0,0,0,0,0)),constraints=as.integer(c(0,0,0,0,0)),probe.type.trt.factor=NULL,max.probe.type.trt.factor=0,probe.trt.factor=NULL,max.probe.trt.factor=0,chipcovariates =matrix(0,0,0),probe.type.levels=list(),probe.trt.levels=list())
+ 
+   Fitresults <- .Call("rlm_PLMset",pm(Dilution),mm(Dilution),probeNames(Dilution),length(geneNames(Dilution)),R.model,output,modelparam)
+ 
+   ## PMMM ~ -1+ probes.type + probes
+   output <- list(weights = TRUE, residuals = TRUE, varcov = c("none","chiplevel", "all"), resid.SE = TRUE)
+   modelparam <- list(trans.fn="log2", se.type = 4, psi.type = 0, psi.k =1.345,max.its = 20, init.method = "ls",weights.chip=NULL,weights.probe=NULL)
+ 
+   R.model <- list(mmorpm.covariate=0,response.variable=0,which.parameter.types=as.integer(c(0,0,0,1,1)),strata=as.integer(c(0,0,0,0,0)),constraints=as.integer(c(0,0,0,0,-1)),probe.type.trt.factor=NULL,max.probe.type.trt.factor=0,probe.trt.factor=NULL,max.probe.trt.factor=0,chipcovariates =matrix(0,0,0),probe.type.levels=list(),probe.trt.levels=list())
+ 
+   Fitresults <- .Call("rlm_PLMset",pm(Dilution),mm(Dilution),probeNames(Dilution),length(geneNames(Dilution)),R.model,output,modelparam)
+ 
+     ## PMMM ~ -1+ probes.type + probes     with both within treatment factor
+   output <- list(weights = TRUE, residuals = TRUE, varcov = c("none","chiplevel", "all"), resid.SE = TRUE)
+   modelparam <- list(trans.fn="log2", se.type = 4, psi.type = 0, psi.k =1.345,max.its = 20, init.method = "ls",weights.chip=NULL,weights.probe=NULL)
+ 
+   R.model <- list(mmorpm.covariate=0,response.variable=0,which.parameter.types=as.integer(c(0,0,0,1,1)),strata=as.integer(c(0,0,0,2,2)),constraints=as.integer(c(0,0,0,0,-1)),probe.type.trt.factor=as.integer(c(0,0,1,1)),max.probe.type.trt.factor=1,probe.trt.factor=as.integer(c(0,0,1,1)),max.probe.trt.factor=1,chipcovariates =matrix(0,0,0),probe.type.levels=list("blah"=c("A","B")),probe.trt.levels=list("blah"=c("A","B")))
+ 
+   Fitresults <- .Call("rlm_PLMset",pm(Dilution),mm(Dilution),probeNames(Dilution),length(geneNames(Dilution)),R.model,output,modelparam)
+ 
+ 
+     ## PMMM ~ -1+ probes.type + probes     with both within treatment factor and probes also within probe.type
+   output <- list(weights = TRUE, residuals = TRUE, varcov = c("none","chiplevel", "all"), resid.SE = TRUE)
+   modelparam <- list(trans.fn="log2", se.type = 4, psi.type = 0, psi.k =1.345,max.its = 20, init.method = "ls",weights.chip=NULL,weights.probe=NULL)
+ 
+   R.model <- list(mmorpm.covariate=0,response.variable=0,which.parameter.types=as.integer(c(0,0,0,1,1)),strata=as.integer(c(0,0,0,2,4)),constraints=as.integer(c(0,0,0,0,-1)),probe.type.trt.factor=as.integer(c(0,0,1,1)),max.probe.type.trt.factor=1,probe.trt.factor=as.integer(c(0,0,1,1)),max.probe.trt.factor=1,chipcovariates =matrix(0,0,0),probe.type.levels=list("blah"=c("A","B")),probe.trt.levels=list("blah"=c("A","B")))
+ 
+   Fitresults <- .Call("rlm_PLMset",pm(Dilution),mm(Dilution),probeNames(Dilution),length(geneNames(Dilution)),R.model,output,modelparam)
+ 
+ 
+   ## PMMM ~ -1+ probes.type + probes     probe.types within treatment factor and probes also within probe.type
+   output <- list(weights = TRUE, residuals = TRUE, varcov = c("none","chiplevel", "all"), resid.SE = TRUE)
+   modelparam <- list(trans.fn="log2", se.type = 4, psi.type = 0, psi.k =1.345,max.its = 20, init.method = "ls",weights.chip=NULL,weights.probe=NULL)
+ 
+   R.model <- list(mmorpm.covariate=0,response.variable=0,which.parameter.types=as.integer(c(0,0,0,1,1)),strata=as.integer(c(0,0,0,2,3)),constraints=as.integer(c(0,0,0,0,-1)),probe.type.trt.factor=as.integer(c(0,0,1,1)),max.probe.type.trt.factor=1,probe.trt.factor=as.integer(c(0,0,1,1)),max.probe.trt.factor=1,chipcovariates =matrix(0,0,0),probe.type.levels=list("blah"=c("A","B")),probe.trt.levels=list("blah"=c("A","B")))
+ 
+   Fitresults <- .Call("rlm_PLMset",pm(Dilution),mm(Dilution),probeNames(Dilution),length(geneNames(Dilution)),R.model,output,modelparam)
+ 
+  ## PMMM ~ -1+ probes.type + probes     probe.types within samples and probes also within probe.type
+   output <- list(weights = TRUE, residuals = TRUE, varcov = c("none","chiplevel", "all"), resid.SE = TRUE)
+   modelparam <- list(trans.fn="log2", se.type = 4, psi.type = 0, psi.k =1.345,max.its = 20, init.method = "ls",weights.chip=NULL,weights.probe=NULL)
+ 
+   R.model <- list(mmorpm.covariate=0,response.variable=0,which.parameter.types=as.integer(c(0,0,0,1,1)),strata=as.integer(c(0,0,0,1,3)),constraints=as.integer(c(0,0,0,0,-1)),probe.type.trt.factor=as.integer(c(0,0,1,1)),max.probe.type.trt.factor=1,probe.trt.factor=as.integer(c(0,0,1,1)),max.probe.trt.factor=1,chipcovariates =matrix(0,0,0),probe.type.levels=list("blah"=c("A","B")),probe.trt.levels=list("blah"=c("A","B")))
+ 
+   Fitresults <- .Call("rlm_PLMset",pm(Dilution),mm(Dilution),probeNames(Dilution),length(geneNames(Dilution)),R.model,output,modelparam)
+ 
+ 
+ 
+   ## PMMM ~ intercept + probes.type + probes     probe.types within samples and probes also within probe.type
+   output <- list(weights = TRUE, residuals = TRUE, varcov = c("none","chiplevel", "all"), resid.SE = TRUE)
+   modelparam <- list(trans.fn="log2", se.type = 4, psi.type = 0, psi.k =1.345,max.its = 20, init.method = "ls",weights.chip=NULL,weights.probe=NULL)
+   
+   R.model <- list(mmorpm.covariate=0,response.variable=0,which.parameter.types=as.integer(c(1,0,0,1,1)),strata=as.integer(c(0,0,0,1,3)),constraints=as.integer(c(0,0,0,-1,-1)),probe.type.trt.factor=as.integer(c(0,0,1,1)),max.probe.type.trt.factor=1,probe.trt.factor=as.integer(c(0,0,1,1)),max.probe.trt.factor=1,chipcovariates =matrix(0,0,0),probe.type.levels=list("blah"=c("A","B")),probe.trt.levels=list("blah"=c("A","B")))
+   
+   Fitresults <- .Call("rlm_PLMset",pm(Dilution),mm(Dilution),probeNames(Dilution),length(geneNames(Dilution)),R.model,output,modelparam)
+ 
+     ## PMMM ~ intercept + probes      probes also within probe.type
+   output <- list(weights = TRUE, residuals = TRUE, varcov = c("none","chiplevel", "all"), resid.SE = TRUE)
+   modelparam <- list(trans.fn="log2", se.type = 4, psi.type = 0, psi.k =1.345,max.its = 20, init.method = "ls",weights.chip=NULL,weights.probe=NULL)
+   
+   R.model <- list(mmorpm.covariate=0,response.variable=0,which.parameter.types=as.integer(c(1,0,0,0,1)),strata=as.integer(c(0,0,0,0,3)),constraints=as.integer(c(0,0,0,0,-1)),probe.type.trt.factor=as.integer(c(0,0,1,1)),max.probe.type.trt.factor=1,probe.trt.factor=as.integer(c(0,0,1,1)),max.probe.trt.factor=1,chipcovariates =matrix(0,0,0),probe.type.levels=list("blah"=c("A","B")),probe.trt.levels=list("blah"=c("A","B")))
+   
+   Fitresults <- .Call("rlm_PLMset",pm(Dilution),mm(Dilution),probeNames(Dilution),length(geneNames(Dilution)),R.model,output,modelparam)
+ 
+      ## PMMM ~ -1+ probes      probes also within probe.type
+   output <- list(weights = TRUE, residuals = TRUE, varcov = c("none","chiplevel", "all"), resid.SE = TRUE)
+   modelparam <- list(trans.fn="log2", se.type = 4, psi.type = 0, psi.k =1.345,max.its = 20, init.method = "ls",weights.chip=NULL,weights.probe=NULL)
+   
+   R.model <- list(mmorpm.covariate=0,response.variable=0,which.parameter.types=as.integer(c(0,0,0,0,1)),strata=as.integer(c(0,0,0,0,3)),constraints=as.integer(c(0,0,0,0,0)),probe.type.trt.factor=as.integer(c(0,0,1,1)),max.probe.type.trt.factor=1,probe.trt.factor=as.integer(c(0,0,1,1)),max.probe.trt.factor=1,chipcovariates =matrix(0,0,0),probe.type.levels=list("blah"=c("A","B")),probe.trt.levels=list("blah"=c("A","B")))
+   
+   Fitresults <- .Call("rlm_PLMset",pm(Dilution),mm(Dilution),probeNames(Dilution),length(geneNames(Dilution)),R.model,output,modelparam)
+ 
+   # now play with varcov output
+   output <- list(weights = TRUE, residuals = TRUE, varcov ="chiplevel", resid.SE = TRUE)
+   modelparam <- list(trans.fn="log2", se.type = 4, psi.type = 0, psi.k =1.345,max.its = 20, init.method = "ls",weights.chip=NULL,weights.probe=NULL)
+   
+   R.model <- list(mmorpm.covariate=0,response.variable=0,which.parameter.types=as.integer(c(0,0,1,0,1)),strata=as.integer(c(0,0,0,0,0)),constraints=as.integer(c(0,0,0,0,-1)),probe.type.trt.factor=as.integer(c(0,0,1,1)),max.probe.type.trt.factor=1,probe.trt.factor=as.integer(c(0,0,1,1)),max.probe.trt.factor=1,chipcovariates =matrix(0,0,0),probe.type.levels=list("blah"=c("A","B")),probe.trt.levels=list("blah"=c("A","B")))
+   
+   Fitresults <- .Call("rlm_PLMset",pm(Dilution),mm(Dilution),probeNames(Dilution),length(geneNames(Dilution)),R.model,output,modelparam)
+ 
+  # now play with varcov output and treatment
+   output <- list(weights = TRUE, residuals = TRUE, varcov ="chiplevel", resid.SE = TRUE)
+   modelparam <- list(trans.fn="log2", se.type = 4, psi.type = 0, psi.k =1.345,max.its = 20, init.method = "ls",weights.chip=NULL,weights.probe=NULL)
+   
+  treatment.effect <- c(1,1,2,2)
+ 
+   covariates <- model.matrix(~ -1 + as.factor(treatment.effect))
+ 
+   R.model <- list(mmorpm.covariate=0,response.variable=0,which.parameter.types=as.integer(c(0,1,0,0,0)),strata=as.integer(c(0,0,0,2,0)),constraints=as.integer(c(0,0,0,0,0)),probe.type.trt.factor=as.integer(c(0,0,1,1)),max.probe.type.trt.factor=1,probe.trt.factor=as.integer(c(0,0,1,1)),max.probe.trt.factor=0,chipcovariates =covariates,probe.type.levels=list("blah"=c("A","B")),probe.trt.levels=list("blah"=c("A","B")))
+ 
+   Fitresults <- .Call("rlm_PLMset",pm(Dilution),mm(Dilution),probeNames(Dilution),length(geneNames(Dilution)),R.model,output,modelparam)
+ 
+   
+ 
+   # now play with varcov output and an intercept
+   output <- list(weights = TRUE, residuals = TRUE, varcov ="chiplevel", resid.SE = TRUE)
+   modelparam <- list(trans.fn="log2", se.type = 4, psi.type = 0, psi.k =1.345,max.its = 20, init.method = "ls",weights.chip=NULL,weights.probe=NULL)
+   
+   R.model <- list(mmorpm.covariate=0,response.variable=0,which.parameter.types=as.integer(c(1,0,1,0,1)),strata=as.integer(c(0,0,0,0,0)),constraints=as.integer(c(0,0,-1,0,-1)),probe.type.trt.factor=as.integer(c(0,0,1,1)),max.probe.type.trt.factor=1,probe.trt.factor=as.integer(c(0,0,1,1)),max.probe.trt.factor=1,chipcovariates =matrix(0,0,0),probe.type.levels=list("blah"=c("A","B")),probe.trt.levels=list("blah"=c("A","B")))
+   
+   Fitresults <- .Call("rlm_PLMset",pm(Dilution),mm(Dilution),probeNames(Dilution),length(geneNames(Dilution)),R.model,output,modelparam)
+ 
+ 
+ 
+  # now play with varcov output and treatment and intercept
+   output <- list(weights = TRUE, residuals = TRUE, varcov ="chiplevel", resid.SE = TRUE)
+   modelparam <- list(trans.fn="log2", se.type = 4, psi.type = 0, psi.k =1.345,max.its = 20, init.method = "ls",weights.chip=NULL,weights.probe=NULL)
+   
+  treatment.effect <- c(1,1,2,2)
+ 
+   covariates <- matrix(model.matrix(~ as.factor(treatment.effect))[,2])
+   colnames(covariates) <- "trt_2"
+ 
+   R.model <- list(mmorpm.covariate=0,response.variable=0,which.parameter.types=as.integer(c(1,1,0,0,0)),strata=as.integer(c(0,0,0,2,0)),constraints=as.integer(c(0,0,0,0,0)),probe.type.trt.factor=as.integer(c(0,0,1,1)),max.probe.type.trt.factor=1,probe.trt.factor=as.integer(c(0,0,1,1)),max.probe.trt.factor=0,chipcovariates =covariates,probe.type.levels=list("blah"=c("A","B")),probe.trt.levels=list("blah"=c("A","B")))
+ 
+   Fitresults <- .Call("rlm_PLMset",pm(Dilution),mm(Dilution),probeNames(Dilution),length(geneNames(Dilution)),R.model,output,modelparam)
+ 
+   
+ 
+  # now play with varcov all option output and treatment and intercept
+   output <- list(weights = TRUE, residuals = TRUE, varcov ="all", resid.SE = TRUE)
+   modelparam <- list(trans.fn="log2", se.type = 4, psi.type = 0, psi.k =1.345,max.its = 20, init.method = "ls",weights.chip=NULL,weights.probe=NULL)
+   
+  treatment.effect <- c(1,1,2,2)
+    
+   covariates <- matrix(model.matrix(~ as.factor(treatment.effect))[,2])
+   colnames(covariates) <- "trt_2"
+   R.model <- list(mmorpm.covariate=0,response.variable=0,which.parameter.types=as.integer(c(1,1,0,0,0)),strata=as.integer(c(0,0,0,2,0)),constraints=as.integer(c(0,0,0,0,0)),probe.type.trt.factor=as.integer(c(0,0,1,1)),max.probe.type.trt.factor=1,probe.trt.factor=as.integer(c(0,0,1,1)),max.probe.trt.factor=0,chipcovariates =covariates,probe.type.levels=list("blah"=c("A","B")),probe.trt.levels=list("blah"=c("A","B")))
+ 
+   Fitresults <- .Call("rlm_PLMset",pm(Dilution),mm(Dilution),probeNames(Dilution),length(geneNames(Dilution)),R.model,output,modelparam)
+ 
+  # now play with varcov all option output and samples and intercept
+   output <- list(weights = TRUE, residuals = TRUE, varcov ="all", resid.SE = TRUE)
+   modelparam <- list(trans.fn="log2", se.type = 4, psi.type = 0, psi.k =1.345,max.its = 20, init.method = "ls",weights.chip=NULL,weights.probe=NULL)
+   
+   R.model <- list(mmorpm.covariate=0,response.variable=0,which.parameter.types=as.integer(c(1,0,1,0,1)),strata=as.integer(c(0,0,0,2,0)),constraints=as.integer(c(0,0,-1,0,-1)),probe.type.trt.factor=as.integer(c(0,0,1,1)),max.probe.type.trt.factor=1,probe.trt.factor=as.integer(c(0,0,1,1)),max.probe.trt.factor=0,chipcovariates =matrix(0,0,0),probe.type.levels=list("blah"=c("A","B")),probe.trt.levels=list("blah"=c("A","B")))
+ 
+   Fitresults <- .Call("rlm_PLMset",pm(Dilution),mm(Dilution),probeNames(Dilution),length(geneNames(Dilution)),R.model,output,modelparam)
+ 
+        # now play with varcov all option output and samples and intercept, MM covarite
+     output <- list(weights = TRUE, residuals = TRUE, varcov ="all", resid.SE = TRUE)
+   modelparam <- list(trans.fn="log2", se.type = 4, psi.type = 0, psi.k =1.345,max.its = 20, init.method = "ls",weights.chip=NULL,weights.probe=NULL)
+   
+   R.model <- list(mmorpm.covariate=1,response.variable=1,which.parameter.types=as.integer(c(1,0,1,0,1)),strata=as.integer(c(0,0,0,2,0)),constraints=as.integer(c(0,0,-1,0,-1)),probe.type.trt.factor=as.integer(c(0,0,1,1)),max.probe.type.trt.factor=1,probe.trt.factor=as.integer(c(0,0,1,1)),max.probe.trt.factor=0,chipcovariates =matrix(0,0,0),probe.type.levels=list("blah"=c("A","B")),probe.trt.levels=list("blah"=c("A","B")))
+ 
+   Fitresults <- .Call("rlm_PLMset",pm(Dilution),mm(Dilution),probeNames(Dilution),length(geneNames(Dilution)),R.model,output,modelparam)
+ 
+ 
+ 
+ 
+ 
+ 
+ 
+   ## now play with varcov all option output and samples and intercept, MM covariate and input chip weights
+   output <- verify.output.param(list(weights = TRUE, residuals = TRUE, varcov ="all", resid.SE = TRUE))
+   modelparam <- list(trans.fn="log2", se.type = 4, psi.type = 0, psi.k =1.345,max.its = 20, init.method = "ls",weights.chip=c(1,1,0.5,0.5),weights.probe=NULL)
+   
+   R.model <- list(mmorpm.covariate=0,response.variable=1,which.parameter.types=as.integer(c(0,0,1,0,1)),strata=as.integer(c(0,0,0,2,0)),constraints=as.integer(c(0,0,0,0,-1)),probe.type.trt.factor=as.integer(c(0,0,1,1)),max.probe.type.trt.factor=1,probe.trt.factor=as.integer(c(0,0,1,1)),max.probe.trt.factor=0,chipcovariates =matrix(0,0,0),probe.type.levels=list("blah"=c("A","B")),probe.trt.levels=list("blah"=c("A","B")))
+ 
+   Fitresults <- .Call("rlm_PLMset",pm(Dilution),mm(Dilution),probeNames(Dilution),length(geneNames(Dilution)),R.model,output,modelparam)
+ 
+   ## now play with varcov all option output and samples and intercept, MM covariate and input chip weights
+   output <- list(weights = TRUE, residuals = TRUE, varcov ="all", resid.SE = TRUE)
+   modelparam <- list(trans.fn="log2", se.type = 4, psi.type = 0, psi.k =1.345,max.its = 20, init.method = "ls",weights.chip=NULL,weights.probe=runif(201800))
+   
+   R.model <- list(mmorpm.covariate=0,response.variable=1,which.parameter.types=as.integer(c(0,0,1,0,1)),strata=as.integer(c(0,0,0,2,0)),constraints=as.integer(c(0,0,0,0,-1)),probe.type.trt.factor=as.integer(c(0,0,1,1)),max.probe.type.trt.factor=1,probe.trt.factor=as.integer(c(0,0,1,1)),max.probe.trt.factor=0,chipcovariates =matrix(0,0,0),probe.type.levels=list("blah"=c("A","B")),probe.trt.levels=list("blah"=c("A","B")))
+ 
+   Fitresults <- .Call("rlm_PLMset",pm(Dilution),mm(Dilution),probeNames(Dilution),length(geneNames(Dilution)),R.model,output,modelparam)
+ 
+ 
+ 
+   output <- list(weights = TRUE, residuals = TRUE, varcov ="all", resid.SE = TRUE)
+   modelparam <- list(trans.fn="log2", se.type = 4, psi.type = 0, psi.k =1.345,max.its = 20, init.method = "ls",weights.chip=NULL,weights.probe=c(rep(c(1,0.5),c(201800,201800))))
+   
+   R.model <- list(mmorpm.covariate=0,response.variable=0,which.parameter.types=as.integer(c(0,0,1,0,1)),strata=as.integer(c(0,0,0,2,0)),constraints=as.integer(c(0,0,0,0,-1)),probe.type.trt.factor=as.integer(c(0,0,1,1)),max.probe.type.trt.factor=1,probe.trt.factor=as.integer(c(0,0,1,1)),max.probe.trt.factor=0,chipcovariates =matrix(0,0,0),probe.type.levels=list("blah"=c("A","B")),probe.trt.levels=list("blah"=c("A","B")))
+ 
+   Fitresults <- .Call("rlm_PLMset",pm(Dilution),mm(Dilution),probeNames(Dilution),length(geneNames(Dilution)),R.model,output,modelparam)
+   
+   
+ 
+   output <- list(weights = TRUE, residuals = TRUE, varcov ="all", resid.SE = TRUE)
+   modelparam <- list(trans.fn="cuberoot", se.type = 4, psi.type = 0, psi.k =1.345,max.its = 20, init.method = "ls",weights.chip=NULL,weights.probe=NULL)
+   
+   R.model <- list(mmorpm.covariate=0,response.variable=0,which.parameter.types=as.integer(c(0,0,1,0,1)),strata=as.integer(c(0,0,0,2,0)),constraints=as.integer(c(0,0,0,0,-1)),probe.type.trt.factor=as.integer(c(0,0,1,1)),max.probe.type.trt.factor=1,probe.trt.factor=as.integer(c(0,0,1,1)),max.probe.trt.factor=0,chipcovariates =matrix(0,0,0),probe.type.levels=list("blah"=c("A","B")),probe.trt.levels=list("blah"=c("A","B")))
+ 
+   Fitresults <- .Call("rlm_PLMset",pm(Dilution),mm(Dilution),probeNames(Dilution),length(geneNames(Dilution)),R.model,output,modelparam)
+   
+   
+ 
+   output <- list(weights = TRUE, residuals = TRUE, varcov ="all", resid.SE = TRUE)
+   modelparam <- list(trans.fn="log10", se.type = 4, psi.type = 0, psi.k =1.345,max.its = 20, init.method = "ls",weights.chip=NULL,weights.probe=NULL)
+   
+   R.model <- list(mmorpm.covariate=0,response.variable=0,which.parameter.types=as.integer(c(0,0,1,0,1)),strata=as.integer(c(0,0,0,2,0)),constraints=as.integer(c(0,0,0,0,-1)),probe.type.trt.factor=as.integer(c(0,0,1,1)),max.probe.type.trt.factor=1,probe.trt.factor=as.integer(c(0,0,1,1)),max.probe.trt.factor=0,chipcovariates =matrix(0,0,0),probe.type.levels=list("blah"=c("A","B")),probe.trt.levels=list("blah"=c("A","B")))
+ 
+   Fitresults <- .Call("rlm_PLMset",pm(Dilution),mm(Dilution),probeNames(Dilution),length(geneNames(Dilution)),R.model,output,modelparam)
+   
+ }
> 
> 
> 
> if (test.PLM.modelmatrix){
+ 
+   library(affyPLM);data(Dilution)
+   
+   #PLM.designmatrix3(Dilution)
+   
+   #PLM.designmatrix3(Dilution,model=MM ~ PM -1 + samples +probe.type:probes)
+   
+   #PLM.designmatrix3(Dilution,model=MM ~ PM -1 + samples:probe.type + liver:probe.type:probes + liver:samples)
+   #PLM.designmatrix3(Dilution,model=MM ~ PM + samples:probe.type + liver:probe.type:probes + liver + samples)
+ 
+ 
+ 
+ 
+   output <- list(weights = TRUE, residuals = TRUE, varcov ="all", resid.SE = TRUE)
+   modelparam <- list(trans.fn="log2", se.type = 4, psi.type = 0, psi.k =1.345,max.its = 20, init.method = "ls",weights.chip=NULL,weights.probe=NULL)
+   #blah <- c(1,5,5,1)
+   #R.model <- PLM.designmatrix3(Dilution,model=PMMM ~ probes + blah,constraint.type=c(probes="contr.sum"))
+   #R.model <- PLM.designmatrix3(Dilution,model=PMMM ~ -1 + blah:probe.type)
+   #R.model <- PLM.designmatrix3(Dilution,model=PMMM ~ -1 +probes:probe.type)
+   #R.model <- PLM.designmatrix3(Dilution,model=PMMM ~ -1 +probes:blah)
+   #R.model <- PLM.designmatrix3(Dilution,model=PMMM ~ -1 +probes:probe.type:blah)
+   #output <- list(weights = TRUE, residuals = TRUE, varcov ="chiplevel", resid.SE = TRUE)
+ #  R.model <- PLM.designmatrix3(Dilution,model=PMMM ~ samples,constraint.type=c(samples="contr.sum"))
+ #  R.model <-  PLM.designmatrix3(Dilution,model=PMMM ~ blah)
+ #   R.model <- PLM.designmatrix3(Dilution,model=PMMM ~ -1 + samples)
+   #R.model <- PLM.designmatrix3(Dilution,model=PMMM ~ probes + blah)
+   #R.model <- PLM.designmatrix3(Dilution,model=PMMM ~ probes + blah)
+   #Fitresults <- .Call("rlm_PLMset",pm(Dilution),mm(Dilution),probeNames(Dilution),length(geneNames(Dilution)),R.model,output,modelparam)
+ 
+   library(affyPLM);data(Dilution)
+    output <- list(weights = TRUE, residuals = TRUE, varcov ="chiplevel", resid.SE = TRUE)
+   modelparam <- list(trans.fn="log2", se.type = 4, psi.type = 0, psi.k =1.345,max.its = 20, init.method = "ls",weights.chip=NULL,weights.probe=NULL)
+   R.model <- PLM.designmatrix3(Dilution,model=PMMM ~ probe.type + probe.type:probes + samples)
+   Fitresults <- .Call("rlm_PLMset",pm(Dilution),mm(Dilution),probeNames(Dilution),length(geneNames(Dilution)),R.model,output,modelparam)
+ 
+   library(affyPLM);data(Dilution)
+   output <- list(weights = TRUE, residuals = TRUE, varcov ="chiplevel", resid.SE = TRUE)
+   modelparam <- list(trans.fn="log2", se.type = 4, psi.type = 0, psi.k =1.345,max.its = 20, init.method = "ls",weights.chip=NULL,weights.probe=NULL)
+   R.model <- PLM.designmatrix3(Dilution,model=PMMM ~ samples:probe.type + probe.type:probes + samples)
+   Fitresults <- .Call("rlm_PLMset",pm(Dilution),mm(Dilution),probeNames(Dilution),length(geneNames(Dilution)),R.model,output,modelparam)
+   
+   
+  output <- list(weights = TRUE, residuals = TRUE, varcov ="chiplevel", resid.SE = TRUE)
+   modelparam <- list(trans.fn="log2", se.type = 4, psi.type = 0, psi.k =1.345,max.its = 20, init.method = "ls",weights.chip=NULL,weights.probe=NULL)
+   blah <- c(1,2,2)
+   R.model <- PLM.designmatrix3(Dilution,model=PMMM ~ blah:probe.type + probe.type:probes + samples)
+   Fitresults <- .Call("rlm_PLMset",pm(Dilution),mm(Dilution),probeNames(Dilution),length(geneNames(Dilution)),R.model,output,modelparam)
+ 
+   
+   output <- list(weights = TRUE, residuals = TRUE, varcov ="all", resid.SE = TRUE)
+   modelparam <- list(trans.fn="log2", se.type = 4, psi.type = 0, psi.k =1.345,max.its = 20, init.method = "ls",weights.chip=NULL,weights.probe=NULL)
+   blah <- c(1,2,2)
+   R.model <- PLM.designmatrix3(Dilution,model=PM ~ -1 + probes + MM + blah)
+   Fitresults <- .Call("rlm_PLMset",pm(Dilution),mm(Dilution),probeNames(Dilution),length(geneNames(Dilution)),R.model,output,modelparam)
+ 
+   
+   output <- list(weights = TRUE, residuals = TRUE, varcov ="all", resid.SE = TRUE)
+   modelparam <- list(trans.fn="log2", se.type = 4, psi.type = 0, psi.k =1.345,max.its = 20, init.method = "ls",weights.chip=NULL,weights.probe=NULL)
+   blah <- c(1,2,2)
+   R.model <- PLM.designmatrix3(Dilution,model=PM ~ -1 + probes + MM + samples)
+   Fitresults <- .Call("rlm_PLMset",pm(Dilution),mm(Dilution),probeNames(Dilution),length(geneNames(Dilution)),R.model,output,modelparam)
+   
+ 
+ 
+ 
+ 
+ #test some of the verification functions
+ 
+ 
+   output <- verify.output.param()
+   modelparam <- verify.model.param(Dilution,PM ~ -1 + probes + MM + samples)
+   R.model <- PLM.designmatrix3(Dilution,model=PM ~ -1 + probes + MM + samples)
+  
+   Fitresults <- .Call("rlm_PLMset",pm(Dilution),mm(Dilution),probeNames(Dilution),length(geneNames(Dilution)),R.model,output,modelparam)
+   
+   ##verify.model.param(Dilution,PM ~ -1 + probes + MM + samples,model.param=list(weights.probe=rep(1,10)))
+ 
+    modelparam <- verify.model.param(Dilution,PMMM ~ -1 + probes + samples,model.param=list(weights.chip=c(1,2,3),weights.probe=rep(1,2400*2)))
+   R.model <- PLM.designmatrix3(Dilution,model=PMMM ~ -1 + probes + samples)
+   Fitresults <- .Call("rlm_PLMset",pm(Dilution),mm(Dilution),probeNames(Dilution),length(geneNames(Dilution)),R.model,output,modelparam)
+ 
+ 
+   
+  modelparam <- verify.model.param(Dilution,PM ~ -1 + probes + samples,model.param=list())
+   R.model <- PLM.designmatrix3(Dilution,model=PM ~ -1 + probes + samples)
+   Fitresults <- .Call("rlm_PLMset",pm(Dilution),mm(Dilution),probeNames(Dilution),length(geneNames(Dilution)),R.model,output,modelparam)
+   ## probes <- rep(1:16,3)
+   ##  chips <- rep(1:3,c(16,16,16))
+ 
+   ## library(MASS)
+   
+   ##fit <- rlm(log2(as.vector(pm(Dilution,"HG2188-HT2258_at"))) ~ -1 + as.factor(chips) + C(as.factor(probes),"contr.sum"))
+   
+ 
+ #test creating a PLMset based on the output from rlm_PLMset
+ 
+ ###  x <- new("PLMset")
+ ###  x@chip.coefs=Fitresults[[1]]
+ ###  x@probe.coefs= Fitresults[[2]]
+ ###  x@weights=Fitresults[[3]]
+ ###  x@se.chip.coefs=Fitresults[[4]]
+ ###  x@se.probe.coefs=Fitresults[[5]]
+ ###  x@exprs=Fitresults[[6]]
+ ###  x@se.exprs=Fitresults[[7]]
+ ###  x@residuals=Fitresults[[8]]
+ ###  x@residualSE=Fitresults[[9]]
+ ###  x@varcov = Fitresults[[10]]
+ ###  x@cdfName = Dilution@cdfName
+  ### x@phenoData = Dilution@phenoData
+  ### x@annotation = Dilution@annotation
+ ###  x@description = Dilution@description
+ ###  x@notes = Dilution@notes
+ ###  x@nrow= Dilution@nrow
+ ###  x@ncol= Dilution@ncol
+ ### x@model.description = c(x@model.description, list(R.model=R.model))
+ ###  image(x)
+ 
+ 
+ 
+ 
+ ###  data(Dilution)
+ ###  output <- verify.output.param()
+ ###  modelparam <- verify.model.param(Dilution,PMMM ~ -1 + probe.type:probes + samples + samples:probe.type,model.param=list())
+ ###  R.model <- PLM.designmatrix3(Dilution,model=PMMM ~ -1 + probe.type:probes + samples+ samples:probe.type)
+ ###  Fitresults <- .Call("rlm_PLMset",pm(Dilution),mm(Dilution),probeNames(Dilution),length(geneNames(Dilution)),R.model,output,modelparam)
+ ###  output <- verify.output.param()
+ ###  modelparam <- verify.model.param(Dilution,MM ~ -1 + probes + samples,model.param=list())
+ ###  R.model <- PLM.designmatrix3(Dilution,model=MM ~ -1 + probes + samples)
+ ###  Fitresults <- .Call("rlm_PLMset",pm(Dilution),mm(Dilution),probeNames(Dilution),length(geneNames(Dilution)),R.model,output,modelparam)
+   
+   
+ 
+ ###  x <- new("PLMset")
+  ### x@chip.coefs=Fitresults[[1]]
+ ###  x@probe.coefs= Fitresults[[2]]
+ ###  x@weights=Fitresults[[3]]
+ ###  x@se.chip.coefs=Fitresults[[4]]
+ ###  x@se.probe.coefs=Fitresults[[5]]
+ ###  x@exprs=Fitresults[[6]]
+ ###  x@se.exprs=Fitresults[[7]]
+  ### x@residuals=Fitresults[[8]]
+ ###  x@residualSE=Fitresults[[9]]
+ ###  x@varcov = Fitresults[[10]]
+ ###  x@cdfName = Dilution@cdfName
+ ###  x@phenoData = Dilution@phenoData
+ ###  x@annotation = Dilution@annotation
+ ###  x@description = Dilution@description
+ ###  x@notes = Dilution@notes
+ ###  x@nrow= Dilution@nrow
+ ###  x@ncol= Dilution@ncol
+ ###  x@model.description = c(x@model.description, list(R.model=R.model))
+ ###  image(x)
+ ###  image(x,type="pos.resids")
+ ###  image(x,type="neg.resids")
+ ###  image(x,type="sign.resids")
+ 
+ ###  resid(x,"1091_at")
+ 
+ 
+ 
+ ###  weights(x,c("1091_at","1092_at"))
+ 
+ 
+ ###  image(x,type="resids",standardize=TRUE)
+ 
+ 
+ 
+ 
+   
+   
+ }
> 
> 
> 
> 
> 
> if (test.rlm){
+ 
+ 
+   library(affyPLM);data(Dilution)
+ 
+   y <- as.vector(log2(pm(Dilution)[1:16,]))
+ 
+   w <- runif(64)
+ 
+   probes <- rep(1:16,4)
+   samples <- rep(1:4,c(16,16,16,16))
+ 
+   x <- model.matrix( ~ -1 + as.factor(samples) + C(as.factor(probes),"contr.sum"))
+   x <- as.vector(x)
+ 
+   cols <- 19
+   rows <- 64
+   
+ 
+ #  rlm_wfit_R(double *x, double *y, double *w, int *rows, int *cols, double *out_beta, double *out_resids, double *out_weights)
+ 
+   fit1 <-.C("rlm_wfit_R",as.double(x),as.double(y),as.double(w),as.integer(rows),as.integer(cols),double(cols),double(rows),double(rows))
+ 
+ 
+   library(MASS)
+ 
+   fit2 <- rlm(y ~ -1 + as.factor(samples) + C(as.factor(probes),"contr.sum"),weights=w,wt.method="case")
+ 
+   if (any(abs(coef(fit2) - fit1[[6]]) > 10e-14)){
+     stop("Weighted RLM did not work")
+   }
+ 
+ 
+ 
+ 
+ 
+   y <- as.vector(log2(pm(Dilution,"1001_at")))
+   x <- as.vector(log2(mm(Dilution,"1001_at")))
+ 
+   rlm(y ~ -1 + x + as.factor(samples) + C(as.factor(probes),"contr.sum"))
+ 
+ 
+ 
+ 
+ 
+ 
+ 
+ 
+ 
+ 
+   
+ }
> 
> 
> 
> 
> proc.time()
   user  system elapsed 
   1.87    0.04    1.89 

R version 4.1.3 (2022-03-10) -- "One Push-Up"
Copyright (C) 2022 The R Foundation for Statistical Computing
Platform: i386-w64-mingw32/i386 (32-bit)

R is free software and comes with ABSOLUTELY NO WARRANTY.
You are welcome to redistribute it under certain conditions.
Type 'license()' or 'licence()' for distribution details.

R is a collaborative project with many contributors.
Type 'contributors()' for more information and
'citation()' on how to cite R or R packages in publications.

Type 'demo()' for some demos, 'help()' for on-line help, or
'help.start()' for an HTML browser interface to help.
Type 'q()' to quit R.

> do.all.tests <- FALSE
> if (do.all.tests){
+ 
+ # this file tests fitPLM and the PLMset object
+ 
+ library(affyPLM)
+ 
+ library(affydata)
+ data(Dilution)
+ 
+ 
+ Pset <- fitPLM(Dilution)
+ 
+ #check accessors for parameters and se
+ 
+ coefs(Pset)[1:5,]
+ se(Pset)[1:5,]
+ coefs.probe(Pset)[1:5]
+ se.probe(Pset)[1:5]
+ coefs.const(Pset)
+ se.const(Pset)
+ 
+ #accessors for weights and residuals
+ 
+ weights(Pset)[[1]][1:5,]
+ resid(Pset)[[1]][1:5,]
+ 
+ 
+ #test varcov
+ 
+ Pset <- fitPLM(Dilution,background=FALSE,normalize=FALSE,output.param=list(varcov="chiplevel"))
+ varcov(Pset)[1:3]
+ 
+ 
+ #test each of the possible weight functions
+ Pset <- fitPLM(Dilution,background=FALSE,normalize=FALSE,model.param=list(psi.type="Huber"))
+ Pset <- fitPLM(Dilution,background=FALSE,normalize=FALSE,model.param=list(psi.type="fair"))
+ Pset <- fitPLM(Dilution,background=FALSE,normalize=FALSE,model.param=list(psi.type="Cauchy"))
+ Pset <- fitPLM(Dilution,background=FALSE,normalize=FALSE,model.param=list(psi.type="Geman-McClure"))
+ Pset <- fitPLM(Dilution,background=FALSE,normalize=FALSE,model.param=list(psi.type="Welsch"))
+ Pset <- fitPLM(Dilution,background=FALSE,normalize=FALSE,model.param=list(psi.type="Tukey"))
+ Pset <- fitPLM(Dilution,background=FALSE,normalize=FALSE,model.param=list(psi.type="Andrews"))
+ 
+ # a larger example to do some testing of the graphical functions
+ 
+ data(Dilution)
+ 
+ Pset <- fitPLM(Dilution)
+ 
+ #testing the image capabilities
+ 
+ image(Pset,which=2)
+ image(Pset,which=2,type="resids")
+ image(Pset,which=2,type="pos.resids")
+ image(Pset,which=2,type="neg.resids")
+ image(Pset,which=2,type="resids",use.log=FALSE,add.legend=TRUE)
+ 
+ boxplot(Pset)
+ Mbox(Pset)
+ 
+ 
+ #test some non-default models functions
+ # no preprocessing for speed
+ 
+ Pset <- fitPLM(Dilution, PM ~ -1 + probes + liver,background=FALSE,normalize=FALSE)
+ coefs(Pset)[1:5,]
+ se(Pset)[1:5,]
+ 
+ 
+ Pset <- fitPLM(Dilution, PM ~ -1 + probes + liver + scanner,background=FALSE,normalize=FALSE)
+ coefs(Pset)[1:5,]
+ se(Pset)[1:5,]
+ 
+ #checking the constraints
+ Pset <- fitPLM(Dilution, PM ~ -1 + probes + liver + scanner,constraint.type=c(default="contr.sum"),background=FALSE,normalize=FALSE)
+ coefs(Pset)[1:5,]
+ se(Pset)[1:5,]
+ 
+ Pset <- fitPLM(Dilution, PM ~ -1 + liver + scanner,constraint.type=c(default="contr.sum"),background=FALSE,normalize=FALSE)
+ coefs(Pset)[1:5,]
+ se(Pset)[1:5,]
+ coefs.probe(Pset) # should be empty
+ 
+ Pset <- fitPLM(Dilution, PM ~ -1 + liver + scanner,constraint.type=c(probes="contr.treatment"),background=FALSE,normalize=FALSE)
+ coefs(Pset)[1:5,]
+ se(Pset)[1:5,]
+ coefs.probe(Pset) # should be empty
+ 
+ 
+ Pset <- fitPLM(Dilution, PM ~ -1 + probes + liver + scanner,constraint.type=c(probes="contr.treatment"),background=FALSE,normalize=FALSE)
+ coefs(Pset)[1:5,]
+ se(Pset)[1:5,]
+ coefs.probe(Pset)[1:16] 
+ 
+ 
+ scanner2 <- c(1,2,1,2) 
+ Pset <- fitPLM(Dilution, PM ~ -1 + probes + liver + scanner2,constraint.type=c(probes="contr.sum"),background=FALSE,normalize=FALSE)
+ coefs(Pset)[1:5,]
+ se(Pset)[1:5,]
+ coefs.probe(Pset)[1:16] 
+ 
+ #
+ #Pset <- fitPLM(Dilution,model=PM~-1+probes+scanner,normalize=FALSE,background=FALSE,model.param=list(se.type=3))
+ #se(Pset)[1:10,]
+ 
+ #check that fitPLM rlm agrees with threestep rlm and threestepPLM rlm
+ 
+ 
+ Pset <- fitPLM(Dilution)
+ eset <- threestep(Dilution,summary.method="rlm")
+ Pset2 <- threestepPLM(Dilution,summary.method="rlm")
+ 
+ if (any(abs(coefs(Pset) - exprs(eset)) > 1e-14)){
+   stop("no agreement between fitPLM and threestep")
+ }
+ 
+ if (any(abs(coefs(Pset) - coefs(Pset2)) > 1e-14)){
+   stop("no agreement between fitPLM and threestep")
+ }
+ }
> 
> proc.time()
   user  system elapsed 
   0.29    0.06    0.34 

R version 4.1.3 (2022-03-10) -- "One Push-Up"
Copyright (C) 2022 The R Foundation for Statistical Computing
Platform: x86_64-w64-mingw32/x64 (64-bit)

R is free software and comes with ABSOLUTELY NO WARRANTY.
You are welcome to redistribute it under certain conditions.
Type 'license()' or 'licence()' for distribution details.

R is a collaborative project with many contributors.
Type 'contributors()' for more information and
'citation()' on how to cite R or R packages in publications.

Type 'demo()' for some demos, 'help()' for on-line help, or
'help.start()' for an HTML browser interface to help.
Type 'q()' to quit R.

> do.all.tests <- FALSE
> if (do.all.tests){
+ 
+ # this file tests fitPLM and the PLMset object
+ 
+ library(affyPLM)
+ 
+ library(affydata)
+ data(Dilution)
+ 
+ 
+ Pset <- fitPLM(Dilution)
+ 
+ #check accessors for parameters and se
+ 
+ coefs(Pset)[1:5,]
+ se(Pset)[1:5,]
+ coefs.probe(Pset)[1:5]
+ se.probe(Pset)[1:5]
+ coefs.const(Pset)
+ se.const(Pset)
+ 
+ #accessors for weights and residuals
+ 
+ weights(Pset)[[1]][1:5,]
+ resid(Pset)[[1]][1:5,]
+ 
+ 
+ #test varcov
+ 
+ Pset <- fitPLM(Dilution,background=FALSE,normalize=FALSE,output.param=list(varcov="chiplevel"))
+ varcov(Pset)[1:3]
+ 
+ 
+ #test each of the possible weight functions
+ Pset <- fitPLM(Dilution,background=FALSE,normalize=FALSE,model.param=list(psi.type="Huber"))
+ Pset <- fitPLM(Dilution,background=FALSE,normalize=FALSE,model.param=list(psi.type="fair"))
+ Pset <- fitPLM(Dilution,background=FALSE,normalize=FALSE,model.param=list(psi.type="Cauchy"))
+ Pset <- fitPLM(Dilution,background=FALSE,normalize=FALSE,model.param=list(psi.type="Geman-McClure"))
+ Pset <- fitPLM(Dilution,background=FALSE,normalize=FALSE,model.param=list(psi.type="Welsch"))
+ Pset <- fitPLM(Dilution,background=FALSE,normalize=FALSE,model.param=list(psi.type="Tukey"))
+ Pset <- fitPLM(Dilution,background=FALSE,normalize=FALSE,model.param=list(psi.type="Andrews"))
+ 
+ # a larger example to do some testing of the graphical functions
+ 
+ data(Dilution)
+ 
+ Pset <- fitPLM(Dilution)
+ 
+ #testing the image capabilities
+ 
+ image(Pset,which=2)
+ image(Pset,which=2,type="resids")
+ image(Pset,which=2,type="pos.resids")
+ image(Pset,which=2,type="neg.resids")
+ image(Pset,which=2,type="resids",use.log=FALSE,add.legend=TRUE)
+ 
+ boxplot(Pset)
+ Mbox(Pset)
+ 
+ 
+ #test some non-default models functions
+ # no preprocessing for speed
+ 
+ Pset <- fitPLM(Dilution, PM ~ -1 + probes + liver,background=FALSE,normalize=FALSE)
+ coefs(Pset)[1:5,]
+ se(Pset)[1:5,]
+ 
+ 
+ Pset <- fitPLM(Dilution, PM ~ -1 + probes + liver + scanner,background=FALSE,normalize=FALSE)
+ coefs(Pset)[1:5,]
+ se(Pset)[1:5,]
+ 
+ #checking the constraints
+ Pset <- fitPLM(Dilution, PM ~ -1 + probes + liver + scanner,constraint.type=c(default="contr.sum"),background=FALSE,normalize=FALSE)
+ coefs(Pset)[1:5,]
+ se(Pset)[1:5,]
+ 
+ Pset <- fitPLM(Dilution, PM ~ -1 + liver + scanner,constraint.type=c(default="contr.sum"),background=FALSE,normalize=FALSE)
+ coefs(Pset)[1:5,]
+ se(Pset)[1:5,]
+ coefs.probe(Pset) # should be empty
+ 
+ Pset <- fitPLM(Dilution, PM ~ -1 + liver + scanner,constraint.type=c(probes="contr.treatment"),background=FALSE,normalize=FALSE)
+ coefs(Pset)[1:5,]
+ se(Pset)[1:5,]
+ coefs.probe(Pset) # should be empty
+ 
+ 
+ Pset <- fitPLM(Dilution, PM ~ -1 + probes + liver + scanner,constraint.type=c(probes="contr.treatment"),background=FALSE,normalize=FALSE)
+ coefs(Pset)[1:5,]
+ se(Pset)[1:5,]
+ coefs.probe(Pset)[1:16] 
+ 
+ 
+ scanner2 <- c(1,2,1,2) 
+ Pset <- fitPLM(Dilution, PM ~ -1 + probes + liver + scanner2,constraint.type=c(probes="contr.sum"),background=FALSE,normalize=FALSE)
+ coefs(Pset)[1:5,]
+ se(Pset)[1:5,]
+ coefs.probe(Pset)[1:16] 
+ 
+ #
+ #Pset <- fitPLM(Dilution,model=PM~-1+probes+scanner,normalize=FALSE,background=FALSE,model.param=list(se.type=3))
+ #se(Pset)[1:10,]
+ 
+ #check that fitPLM rlm agrees with threestep rlm and threestepPLM rlm
+ 
+ 
+ Pset <- fitPLM(Dilution)
+ eset <- threestep(Dilution,summary.method="rlm")
+ Pset2 <- threestepPLM(Dilution,summary.method="rlm")
+ 
+ if (any(abs(coefs(Pset) - exprs(eset)) > 1e-14)){
+   stop("no agreement between fitPLM and threestep")
+ }
+ 
+ if (any(abs(coefs(Pset) - coefs(Pset2)) > 1e-14)){
+   stop("no agreement between fitPLM and threestep")
+ }
+ }
> 
> proc.time()
   user  system elapsed 
   0.26    0.07    0.32 

R version 4.1.3 (2022-03-10) -- "One Push-Up"
Copyright (C) 2022 The R Foundation for Statistical Computing
Platform: i386-w64-mingw32/i386 (32-bit)

R is free software and comes with ABSOLUTELY NO WARRANTY.
You are welcome to redistribute it under certain conditions.
Type 'license()' or 'licence()' for distribution details.

R is a collaborative project with many contributors.
Type 'contributors()' for more information and
'citation()' on how to cite R or R packages in publications.

Type 'demo()' for some demos, 'help()' for on-line help, or
'help.start()' for an HTML browser interface to help.
Type 'q()' to quit R.

> #test the preprocessing functionality
> 
> library(affyPLM)
Loading required package: BiocGenerics

Attaching package: 'BiocGenerics'

The following objects are masked from 'package:stats':

    IQR, mad, sd, var, xtabs

The following objects are masked from 'package:base':

    Filter, Find, Map, Position, Reduce, anyDuplicated, append,
    as.data.frame, basename, cbind, colnames, dirname, do.call,
    duplicated, eval, evalq, get, grep, grepl, intersect, is.unsorted,
    lapply, mapply, match, mget, order, paste, pmax, pmax.int, pmin,
    pmin.int, rank, rbind, rownames, sapply, setdiff, sort, table,
    tapply, union, unique, unsplit, which.max, which.min

Loading required package: affy
Loading required package: Biobase
Welcome to Bioconductor

    Vignettes contain introductory material; view with
    'browseVignettes()'. To cite Bioconductor, see
    'citation("Biobase")', and for packages 'citation("pkgname")'.

Loading required package: gcrma
Loading required package: preprocessCore
> library(affydata)
     Package    LibPath                                      Item      
[1,] "affydata" "C:/Users/biocbuild/bbs-3.14-bioc/R/library" "Dilution"
     Title                        
[1,] "AffyBatch instance Dilution"
> data(Dilution)
> 
> 
> ### NO LONGER SUPPORTED eset <- threestep(Dilution,background.method="RMA.1")
> eset <- threestep(Dilution,background.method="RMA.2")

Warning messages:
1: replacing previous import 'AnnotationDbi::tail' by 'utils::tail' when loading 'hgu95av2cdf' 
2: replacing previous import 'AnnotationDbi::head' by 'utils::head' when loading 'hgu95av2cdf' 
> eset <- threestep(Dilution,background.method="IdealMM")
> eset <- threestep(Dilution,background.method="MAS")
> eset <- threestep(Dilution,background.method="MASIM")
> eset <- threestep(Dilution,background.method="LESN2")
> eset <- threestep(Dilution,background.method="LESN1")
> eset <- threestep(Dilution,background.method="LESN0")
> 
> eset <- threestep(Dilution,normalize.method="quantile",background=FALSE)
> eset <- threestep(Dilution,normalize.method="quantile.probeset",background=FALSE)
> eset <- threestep(Dilution,normalize.method="scaling",background=FALSE)
> 
> 
> 
> proc.time()
   user  system elapsed 
  21.40    0.89   22.28 

R version 4.1.3 (2022-03-10) -- "One Push-Up"
Copyright (C) 2022 The R Foundation for Statistical Computing
Platform: x86_64-w64-mingw32/x64 (64-bit)

R is free software and comes with ABSOLUTELY NO WARRANTY.
You are welcome to redistribute it under certain conditions.
Type 'license()' or 'licence()' for distribution details.

R is a collaborative project with many contributors.
Type 'contributors()' for more information and
'citation()' on how to cite R or R packages in publications.

Type 'demo()' for some demos, 'help()' for on-line help, or
'help.start()' for an HTML browser interface to help.
Type 'q()' to quit R.

> #test the preprocessing functionality
> 
> library(affyPLM)
Loading required package: BiocGenerics

Attaching package: 'BiocGenerics'

The following objects are masked from 'package:stats':

    IQR, mad, sd, var, xtabs

The following objects are masked from 'package:base':

    Filter, Find, Map, Position, Reduce, anyDuplicated, append,
    as.data.frame, basename, cbind, colnames, dirname, do.call,
    duplicated, eval, evalq, get, grep, grepl, intersect, is.unsorted,
    lapply, mapply, match, mget, order, paste, pmax, pmax.int, pmin,
    pmin.int, rank, rbind, rownames, sapply, setdiff, sort, table,
    tapply, union, unique, unsplit, which.max, which.min

Loading required package: affy
Loading required package: Biobase
Welcome to Bioconductor

    Vignettes contain introductory material; view with
    'browseVignettes()'. To cite Bioconductor, see
    'citation("Biobase")', and for packages 'citation("pkgname")'.

Loading required package: gcrma
Loading required package: preprocessCore
> library(affydata)
     Package    LibPath                                      Item      
[1,] "affydata" "C:/Users/biocbuild/bbs-3.14-bioc/R/library" "Dilution"
     Title                        
[1,] "AffyBatch instance Dilution"
> data(Dilution)
> 
> 
> ### NO LONGER SUPPORTED eset <- threestep(Dilution,background.method="RMA.1")
> eset <- threestep(Dilution,background.method="RMA.2")

Warning messages:
1: replacing previous import 'AnnotationDbi::tail' by 'utils::tail' when loading 'hgu95av2cdf' 
2: replacing previous import 'AnnotationDbi::head' by 'utils::head' when loading 'hgu95av2cdf' 
> eset <- threestep(Dilution,background.method="IdealMM")
> eset <- threestep(Dilution,background.method="MAS")
> eset <- threestep(Dilution,background.method="MASIM")
> eset <- threestep(Dilution,background.method="LESN2")
> eset <- threestep(Dilution,background.method="LESN1")
> eset <- threestep(Dilution,background.method="LESN0")
> 
> eset <- threestep(Dilution,normalize.method="quantile",background=FALSE)
> eset <- threestep(Dilution,normalize.method="quantile.probeset",background=FALSE)
> eset <- threestep(Dilution,normalize.method="scaling",background=FALSE)
> 
> 
> 
> proc.time()
   user  system elapsed 
  19.71    0.65   20.36 

R version 4.1.3 (2022-03-10) -- "One Push-Up"
Copyright (C) 2022 The R Foundation for Statistical Computing
Platform: i386-w64-mingw32/i386 (32-bit)

R is free software and comes with ABSOLUTELY NO WARRANTY.
You are welcome to redistribute it under certain conditions.
Type 'license()' or 'licence()' for distribution details.

R is a collaborative project with many contributors.
Type 'contributors()' for more information and
'citation()' on how to cite R or R packages in publications.

Type 'demo()' for some demos, 'help()' for on-line help, or
'help.start()' for an HTML browser interface to help.
Type 'q()' to quit R.

> if (.Platform$OS.type != "windows"){
+ library(affyPLM)
+ 
+ # test threestep and threestepPLM to see if they agree
+ 
+ 
+ check.coefs <- function(Pset,Pset2){
+   if (any(abs(coefs(Pset) - exprs(Pset2)) > 1e-14)){
+     stop("No agreement between threestepPLM and threestep in coefs")
+   }	
+ }
+ 
+ check.resids <- function(Pset,Pset2){
+   if (any(resid(Pset) != resid(Pset2))){
+     stop("No agreement between threestepPLM and rmaPLM/threestep in residuals")
+   }
+ }
+ 
+ 
+ library(affydata)
+ data(Dilution)
+ 
+ Pset <- threestepPLM(Dilution)
+ Pset2 <- threestep(Dilution)
+ check.coefs(Pset,Pset2)
+ 
+ Pset <- threestepPLM(Dilution,summary.method="tukey.biweight")
+ Pset2 <- threestep(Dilution,summary.method="tukey.biweight")
+ check.coefs(Pset,Pset2)
+ 
+ Pset <- threestepPLM(Dilution,summary.method="average.log")
+ Pset2 <- threestep(Dilution,summary.method="average.log")
+ check.coefs(Pset,Pset2)
+ 
+ Pset <- threestepPLM(Dilution,summary.method="rlm")
+ Pset2 <- threestep(Dilution,summary.method="rlm")
+ check.coefs(Pset,Pset2)
+ 
+ Pset <- threestepPLM(Dilution,summary.method="log.average")
+ Pset2 <- threestep(Dilution,summary.method="log.average")
+ check.coefs(Pset,Pset2)
+ 
+ Pset <- threestepPLM(Dilution,summary.method="log.median")
+ Pset2 <- threestep(Dilution,summary.method="log.median")
+ check.coefs(Pset,Pset2)
+ 
+ Pset <- threestepPLM(Dilution,summary.method="median.log")
+ Pset2 <- threestep(Dilution,summary.method="median.log")
+ check.coefs(Pset,Pset2)
+ 
+ Pset <- threestepPLM(Dilution,summary.method="log.2nd.largest")
+ Pset2 <- threestep(Dilution,summary.method="log.2nd.largest")
+ check.coefs(Pset,Pset2)
+ 
+ Pset <- threestepPLM(Dilution,summary.method="lm")
+ Pset2 <- threestep(Dilution,summary.method="lm")
+ check.coefs(Pset,Pset2)
+ 
+ #check if threestepPLM agrees with rmaPLM
+ Pset <- threestepPLM(Dilution)
+ Pset2 <- rmaPLM(Dilution)
+ 
+ if (any(coefs(Pset) != coefs(Pset2))){
+    stop("No agreement between threestepPLM and rmaPLM in coefs")
+ }
+ 
+ 
+ if (any(resid(Pset)[[1]] != resid(Pset2)[[1]])){
+    stop("No agreement between threestepPLM and rmaPLM in residuals")
+ }
+ }
> 
> proc.time()
   user  system elapsed 
   0.31    0.09    0.39 

R version 4.1.3 (2022-03-10) -- "One Push-Up"
Copyright (C) 2022 The R Foundation for Statistical Computing
Platform: x86_64-w64-mingw32/x64 (64-bit)

R is free software and comes with ABSOLUTELY NO WARRANTY.
You are welcome to redistribute it under certain conditions.
Type 'license()' or 'licence()' for distribution details.

R is a collaborative project with many contributors.
Type 'contributors()' for more information and
'citation()' on how to cite R or R packages in publications.

Type 'demo()' for some demos, 'help()' for on-line help, or
'help.start()' for an HTML browser interface to help.
Type 'q()' to quit R.

> if (.Platform$OS.type != "windows"){
+ library(affyPLM)
+ 
+ # test threestep and threestepPLM to see if they agree
+ 
+ 
+ check.coefs <- function(Pset,Pset2){
+   if (any(abs(coefs(Pset) - exprs(Pset2)) > 1e-14)){
+     stop("No agreement between threestepPLM and threestep in coefs")
+   }	
+ }
+ 
+ check.resids <- function(Pset,Pset2){
+   if (any(resid(Pset) != resid(Pset2))){
+     stop("No agreement between threestepPLM and rmaPLM/threestep in residuals")
+   }
+ }
+ 
+ 
+ library(affydata)
+ data(Dilution)
+ 
+ Pset <- threestepPLM(Dilution)
+ Pset2 <- threestep(Dilution)
+ check.coefs(Pset,Pset2)
+ 
+ Pset <- threestepPLM(Dilution,summary.method="tukey.biweight")
+ Pset2 <- threestep(Dilution,summary.method="tukey.biweight")
+ check.coefs(Pset,Pset2)
+ 
+ Pset <- threestepPLM(Dilution,summary.method="average.log")
+ Pset2 <- threestep(Dilution,summary.method="average.log")
+ check.coefs(Pset,Pset2)
+ 
+ Pset <- threestepPLM(Dilution,summary.method="rlm")
+ Pset2 <- threestep(Dilution,summary.method="rlm")
+ check.coefs(Pset,Pset2)
+ 
+ Pset <- threestepPLM(Dilution,summary.method="log.average")
+ Pset2 <- threestep(Dilution,summary.method="log.average")
+ check.coefs(Pset,Pset2)
+ 
+ Pset <- threestepPLM(Dilution,summary.method="log.median")
+ Pset2 <- threestep(Dilution,summary.method="log.median")
+ check.coefs(Pset,Pset2)
+ 
+ Pset <- threestepPLM(Dilution,summary.method="median.log")
+ Pset2 <- threestep(Dilution,summary.method="median.log")
+ check.coefs(Pset,Pset2)
+ 
+ Pset <- threestepPLM(Dilution,summary.method="log.2nd.largest")
+ Pset2 <- threestep(Dilution,summary.method="log.2nd.largest")
+ check.coefs(Pset,Pset2)
+ 
+ Pset <- threestepPLM(Dilution,summary.method="lm")
+ Pset2 <- threestep(Dilution,summary.method="lm")
+ check.coefs(Pset,Pset2)
+ 
+ #check if threestepPLM agrees with rmaPLM
+ Pset <- threestepPLM(Dilution)
+ Pset2 <- rmaPLM(Dilution)
+ 
+ if (any(coefs(Pset) != coefs(Pset2))){
+    stop("No agreement between threestepPLM and rmaPLM in coefs")
+ }
+ 
+ 
+ if (any(resid(Pset)[[1]] != resid(Pset2)[[1]])){
+    stop("No agreement between threestepPLM and rmaPLM in residuals")
+ }
+ }
> 
> proc.time()
   user  system elapsed 
   0.31    0.01    0.31