\name{rma.background.correct} \alias{rma.background.correct} \title{RMA Background Correction} \description{Background correct each column of a matrix } \usage{ rma.background.correct(x,copy=TRUE) } \arguments{ \item{x}{A matrix of intensities where each column corresponds to a chip and each row is a probe.} \item{copy}{Make a copy of matrix before background correctiong. Usually safer to work with a copy, but in certain situations not making a copy of the matrix, but instead background correcting it in place will be more memory friendly.} } \details{ Assumes PMs are a convolution of normal and exponentional. So we observe X+Y where X is backround and Y is signal. \code{bg.adjust} returns E[Y|X+Y, Y>0] as our backround corrected PM. } \value{ A RMA background corrected \code{matrix}. } \references{ Bolstad, BM (2004) \emph{Low Level Analysis of High-density Oligonucleotide Array Data: Background, Normalization and Summarization}. PhD Dissertation. University of California, Berkeley. pp 17-21 } \author{Ben Bolstad, \email{bmbolstad.com}} \keyword{manip}