BulkSignalR 0.99.0 (First release: 2022-03-22) ============================================== * This is the first release of BulkSignalR. BulkSignalR 0.99.0 (2024-09-17) ============================================== * Code redesign : Major update to add the derived classes enabling the comparisons of groups of samples ############################################ # Version 2 : LRDBv1 + Upgrade Reactome # ############################################ 3820 Interactions : 836 Genes annotated as Ligand only. 727 Genes annotated as Receptor only. 39 genes are defined both as ligand and receptor in 332 interactions. ############################ # Version 1 : LRDBv1 # ############################ 3239 Interactions : 786 Genes annotated as Ligand only. 730 Genes annotated as Receptor only. 20 genes are defined both as ligand and receptor in 109 interactions. "ADAM17" "CD36" "CD48" "CD80" "EFNA3" "NECTIN3" "PLG" "PVR" "TYROBP" "ITGB2" "HLA-F" "CEACAM1" "PECAM1" "CD22" "NECTIN1" "CEACAM8" "CD1D" "CD177" "CLEC2B" "CD47" Some interactions were found to be duplicated and duplicates were removed. CCL17 ACKR1 CCL2 ACKR1 CCL5 ACKR1 CCL7 ACKR1 CXCL1 ACKR1 CXCL5 ACKR1 INHBE ACVR2B INHBE ACVR2B INHBE ACVR2B SEMA4A PLXND1 PVR CD96 INHBE ACVR2B Spotted some inversions in description for SEMA4A PLXNB1 interaction. Also ACVR2B was found with different descriptions whereas gene name occurs several times. So Description for each gene was rewritten once according to biomart. Change according to multichecker (https://www.genenames.org/tools/multi-symbol-checker/) Note HLAE was changed to HLA-E. Note BY55 was changed to CD160. Note MTf was changed to MELTF. Note SHP1 was changed to PTPN6. Note SHP2 was changed to PTPN11. Note TIM-1 was changed to HAVCR1. Ambiguous (failed with multichecker): Note NOV was changed to CCN3 according to (hugo,omnipath,celltalk)