TBSignatureProfiler

This is the development version of TBSignatureProfiler; for the stable release version, see TBSignatureProfiler.

Profile RNA-Seq Data Using TB Pathway Signatures

Bioconductor version: Development (3.21)

Gene signatures of TB progression, TB disease, and other TB disease states have been validated and published previously. This package aggregates known signatures and provides computational tools to enlist their usage on other datasets. The TBSignatureProfiler makes it easy to profile RNA-Seq data using these signatures and includes common signature profiling tools including ASSIGN, GSVA, and ssGSEA. Original models for some gene signatures are also available. A shiny app provides some functionality alongside for detailed command line accessibility.

Author: Aubrey R. Odom [aut, cre, dtm] (ORCID: ), David Jenkins [aut, org] (ORCID: ), Xutao Wang [aut], Yue Zhao [ctb] (ORCID: ), Christian Love [ctb], W. Evan Johnson [aut]

Maintainer: Aubrey R. Odom <aodom at bu.edu>

Citation (from within R, enter citation("TBSignatureProfiler")):

Installation

To install this package, start R (version "4.5") and enter:


if (!require("BiocManager", quietly = TRUE))
    install.packages("BiocManager")

# The following initializes usage of Bioc devel
BiocManager::install(version='devel')

BiocManager::install("TBSignatureProfiler")

For older versions of R, please refer to the appropriate Bioconductor release.

Documentation


Reference Manual	PDF

Need some help? Ask on the Bioconductor Support site!

Details

biocViews	DifferentialExpression, GeneExpression, Software
Version	1.19.0
In Bioconductor since	BioC 3.11 (R-4.0) (4.5 years)
License	MIT + file LICENSE
Depends	R (>= 4.4.0)
Imports	ASSIGN(>= 1.23.1), BiocParallel, ComplexHeatmap, DESeq2, DT, edgeR, gdata, ggplot2, glmnet, GSVA(>= 1.51.3), HGNChelper, magrittr, methods, pROC, RColorBrewer, reshape2, ROCit, S4Vectors, singscore, stats, SummarizedExperiment
System Requirements
URL	https://github.com/wejlab/TBSignatureProfiler https://wejlab.github.io/TBSignatureProfiler-docs/
Bug Reports	https://github.com/wejlab/TBSignatureProfiler/issues

Suggests	BiocStyle, caret, circlize, class, covr, dplyr, e1071, impute, knitr, lintr, MASS, plyr, randomForest, rmarkdown, shiny, spelling, sva, testthat
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Build Report	Build Report

Package Archives

Follow Installation instructions to use this package in your R session.

Source Package
Windows Binary (x86_64)
macOS Binary (x86_64)
macOS Binary (arm64)
Source Repository	git clone https://git.bioconductor.org/packages/TBSignatureProfiler
Source Repository (Developer Access)	git clone git@git.bioconductor.org:packages/TBSignatureProfiler
Package Short Url	https://bioconductor.org/packages/TBSignatureProfiler/
Package Downloads Report	Download Stats