GenProSeq

This package is for version 3.17 of Bioconductor; for the stable, up-to-date release version, see GenProSeq.

Generating Protein Sequences with Deep Generative Models


Bioconductor version: 3.17

Generative modeling for protein engineering is key to solving fundamental problems in synthetic biology, medicine, and material science. Machine learning has enabled us to generate useful protein sequences on a variety of scales. Generative models are machine learning methods which seek to model the distribution underlying the data, allowing for the generation of novel samples with similar properties to those on which the model was trained. Generative models of proteins can learn biologically meaningful representations helpful for a variety of downstream tasks. Furthermore, they can learn to generate protein sequences that have not been observed before and to assign higher probability to protein sequences that satisfy desired criteria. In this package, common deep generative models for protein sequences, such as variational autoencoder (VAE), generative adversarial networks (GAN), and autoregressive models are available. In the VAE and GAN, the Word2vec is used for embedding. The transformer encoder is applied to protein sequences for the autoregressive model.

Author: Dongmin Jung [cre, aut]

Maintainer: Dongmin Jung <dmdmjung at gmail.com>

Citation (from within R, enter citation("GenProSeq")):

Installation

To install this package, start R (version "4.3") and enter:


if (!require("BiocManager", quietly = TRUE))
    install.packages("BiocManager")

BiocManager::install("GenProSeq")

For older versions of R, please refer to the appropriate Bioconductor release.

Documentation

To view documentation for the version of this package installed in your system, start R and enter:

browseVignettes("GenProSeq")
GenProSeq HTML R Script
Reference Manual PDF
NEWS Text

Details

biocViews Proteomics, Software
Version 1.4.2
In Bioconductor since BioC 3.15 (R-4.2) (2 years)
License Artistic-2.0
Depends keras, mclust, R (>= 4.2)
Imports tensorflow, word2vec, DeepPINCS, ttgsea, CatEncoders, reticulate, stats
System Requirements
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Suggests ggseqlogo, VAExprs, stringdist, knitr, testthat, rmarkdown
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Package Archives

Follow Installation instructions to use this package in your R session.

Source Package GenProSeq_1.4.2.tar.gz
Windows Binary GenProSeq_1.4.2.zip (64-bit only)
macOS Binary (x86_64) GenProSeq_1.4.2.tgz
macOS Binary (arm64) GenProSeq_1.4.2.tgz
Source Repository git clone https://git.bioconductor.org/packages/GenProSeq
Source Repository (Developer Access) git clone git@git.bioconductor.org:packages/GenProSeq
Bioc Package Browser https://code.bioconductor.org/browse/GenProSeq/
Package Short Url https://bioconductor.org/packages/GenProSeq/
Package Downloads Report Download Stats
Old Source Packages for BioC 3.17 Source Archive