Changes in version 1.2.1 (2022-06-22) + Bugfix for BuildReference: ignores "N" bases when translating codons (instead of returning an error) + Bugfix for BuildReference: more versatile handling of cache locations for BiocFileCache Changes in version 1.1.1 (2022-01-11) + Bugfix for NxtSE constructor. + Bugfix for Consistency filter: previously an "average" filter was used, such that upstream / downstream filter triggers counted for 0.5, whereas it added 1.0 if both up/downstream filters were triggered. From 1.1.1 onwards, 1.0 is added when either upstream or downstream consistency filter is triggered. + Added two new annotation-based filters: Terminus and ExclusiveMXE. See ?NxtFilter for details + Annotated retained introns `RI` are defined by any intron that is completely overlapped by a single exon of any transcript. They are calculated as binary events, i.e. as PSI between RI and specific spliced intron, and do not consider overlapping splice events (unlike `IR` events, which are calculated for all other constitutive introns) Version 1.1.0 + Initial devel release for Bioconductor 3.15 Changes in version 0.99.12 (2021-10-26) + Fixed bug in MakeSE() and CoordToGR() Changes in version 0.99.10 (2021-10-20) + Accounts for when NxtIRFdata cannot fetch data from ExperimentHub Changes in version 0.99.9 (2021-10-20) + Added GetCoverageBins() + Add warning in IRFinder if coordinate sorted BAM file takes too long to run. + Fixed missing coverage data at both ends of plot track. Changes in version 0.99.8 (2021-10-13) + Fixed memory leak when writing COV files Changes in version 0.99.6 (2021-10-12) + Added GetCoverageRegions() which calculates the mean coverage of each region in a given GRanges object + Added BAM2COV() which calculates and creates COV files from BAM files Changes in version 0.99.2 (2021-10-07) + Fixed bug in Find_FASTQ Changes in version 0.99.0 (2021-09-29) + Bioconductor Release