Changes in version 1.2.2: o Bug fix in function HDP.ranking to accomodate the changes in package igraph (version 1.0.1). o Additional steps added to the code of the second case study in the vignette to filter C2 gene sets properly. o Minor changes in the vignette. Changes in version 1.0.0: o The package provides two-sample nonparametric multivariate statistical methods to test specific alternative hypotheses against a null hypothesis. o GSAR depends on package igraph to handle graphs in objects of class igraph and uses some functions too. o New capabilities and future changes will be reported in subsequent versions.